Gastrointestinal absorption of metals (51Cr, 65Zn, 95mTc, 109Cd, 113Sn, 147Pm, and 238Pu) by rats and swine

Sullivan, M.F.; Miller, Bill R.; Goebel, J.C.

doi:10.1016/0013-9351(84)90151-8

Cited by 27 publications

(11 citation statements)

References 26 publications

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“…However, the intestinal absorption of RE seems to depend on the diet. Retention of Pm in the soft tissues in neonatal rats was two orders of magnitude higher than that in adult rats (82), probably because the neonates were on milk diet (84,90 as the dose increased. Even the lethality was abolished at 80 to 100 mg Pr(NO3)3/kg bw (105).…”

Section: Exposure To Rare Earthsmentioning

confidence: 89%

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Hirano¹,

Suzuki²

1996

Environmental Health Perspectives

153

187

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Section: Exposure To Rare Earthsmentioning

confidence: 89%

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Hirano¹,

Suzuki²

1996

Environmental Health Perspectives

153

187

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“…Autoradiography of the rat intestine shows uniform labeling throughout the mucosa and submucosa (24). Also in the present study, cadmium was selectively and almost exclusively deposited in duodenum, with a maximum in the first segment.…”

Section: Mercurymentioning

confidence: 54%

“…Orally administered cadmium is initially deposited in the proximal part of the intestinal tract (19)(20)(21)(22)(23)(24).…”

Section: Mercurymentioning

confidence: 99%

Experimental localization of intestinal uptake sites for metals (Cd, Hg, Zn, Se) in vivo in mice.

Andersen

Nielsen

Sørensen

et al. 1994

Environ Health Perspect

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The intestinal uptake process consists of two separable steps: transport over the luminal membrane into epithelial cytoplasm and transport over the basolateral membrane into serosal fluid. A compound's residence time in mucosal epithelial cytoplasm depends on rates of the two transport processes and, if the rate of the second step is low, on the rate of mucosal sloughing. Using remitting metal isotopes, in vivo labeling profiles of the intestinal tract were obtained from mice eating their normal diet. The results pertain to processes in the functioning, undisturbed intestinal tract. Single-dose chase experiments indicated that intestinal uptake processes were in fact studied. The labeling profiles varied considerably for different metals. Thus, Cd++ was absorbed mainly in duodenum and early jejunum, while Zn++ was taken up in jejunum and ileum. The uptake profile of Hg++ indicated most rapid uptake in proximal jejunum. Selenomethionine labeled the entire intestinal tract, most rapidly the duodenum, the following intestinal segments were labeled with falling rate. This experimental method is rapid and simple. Further studies aim at developing a quantitative model suited for studying interactions between essential and toxic metals at the level of intestinal metabolism. -Environ Health Perspect 102 (Suppl 3):199-206 (1994).

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“…Following oral administration, REEs are rapidly absorbed from the ileum [27][28][29], and upon reaching the bloodstream, their ions are changed into colloidal hydroxides, phosphates, and carbonates [30].…”

Section: Discussionmentioning

confidence: 99%

Distribution, Elimination, and Renal Effects of Single Oral Doses of Europium in Rats

Ohnishi

Usuda

Nakayama

et al. 2011

Biol Trace Elem Res

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Single doses of europium (III) chloride hexahydrate were orally administered to several groups of rats. Cumulative urine samples were taken at 0-24 h, and blood samples were drawn after 24-h administration. The europium concentration was determined in these samples by inductively coupled plasma atomic emission spectroscopy. The volume, creatinine, ß-2-microglobulin, and N-acetyl-ß-D-glucosaminidase were measured in the urine samples to evaluate possible europium-induced renal effects. The blood samples showed low europium distribution, with an average of 77.5 μg/L for all groups. Although the urinary concentration and excretion showed dose-dependent increases, the percentage of europium excreted showed a dose-dependent decrease, with an average of 0.31% in all groups. The administration of europium resulted in a significant decrease of creatinine and a significant increase of urinary volume, N-acetyl-ß-D-glucosaminidase, and ß-2-microglobulin. Rare earth elements, including europium, are believed to form colloidal conjugates that deposit in the reticuloendothelial system and glomeruli. This specific reaction may contribute to low europium bioavailability and renal function disturbances. Despite low bioavailability, the high performance of the analytical method for determination of europium makes the blood and urine sampling suitable tools for monitoring of exposure to this element. The results presented in this study will be of great importance in future studies on the health impacts of rare earth elements.

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Gastrointestinal absorption of metals (51Cr, 65Zn, 95mTc, 109Cd, 113Sn, 147Pm, and 238Pu) by rats and swine

Cited by 27 publications

References 26 publications

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Experimental localization of intestinal uptake sites for metals (Cd, Hg, Zn, Se) in vivo in mice.

Distribution, Elimination, and Renal Effects of Single Oral Doses of Europium in Rats

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