Gastrointestinal and Hepatic Considerations in Critically Ill Hematopoietic Stem Cell Transplantation Patient

Almakadi, Mohammed; Al-Ahmari, Ali; Albeihany, Amal

doi:10.1007/978-3-031-28797-8_28

Cited by 1 publication

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“…Haematogenic stem cell transplantation (HSCT) is a potentially curative, intensive but also challenging approach to treatment for a variety of haematological malignancies [ 1 , 2 , 3 , 4 , 5 ]. However, multiple factors can potentially induce changes in metabolism and body compositions at the time of HSCT, including a high dose of systemic anticancer therapy (SACT), steroids, immunosuppressors, and total body radiation (TBI) which can lead to complications such as mucositis, nausea, vomiting, decreased indigestion, infections, or graft-versus-host disease (GvHD) [ 1 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Nutritional support prevents protein wasting, preserves the lean body mass and energy reserves, recontracts immunity, and diminishes the inflammatory response [ 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Critical Exploration into Current Evidence behind the Role of the Nutritional Support in Adult Patients Who Undergo Haematogenic Stem Cell Transplantation

et al. 2023

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Haematopoietic stem cell transplantation (HSCT) is a treatment option for many haematological conditions in patients of all ages. Nutritional support is important at each stage of treatment, but particular nutritional needs and dictated support occur during the preparatory (conditioning regimen) and post-transplant periods. Patients may require nutritional treatment by the enteral or parenteral route. The quantitative and qualitative composition of meals may change. Vitamin requirements, including vitamin D and vitamin C, might also be different. An adequately composed diet, adapted to the needs of the patient, may influence the occurrence of complications such as graft-versus-host disease (GvHD), gastrointestinal disorders, infections, and reduced survival time. Haematological diseases as well as transplantation can negatively affect the intestinal flora, with negative consequences in the form of mucosal inflammation and disorders of a functional nature. Currently, aspects related to nutrition are crucial in the care of patients after HSCT, and numerous studies, including randomized trials on these aspects, are being conducted. This study serves the critical analysis of current scientific evidence regarding nutritional support for patients after HSCT.

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