Gastrointestinal Bleeding in Patients with Severe SARS-CoV-2

Gadiparthi, Chiranjeevi; Perisetti, Abhilash; Sayana, Hari; Tharian, Benjamin; Inamdar, Sumant; Korman, Andrew

doi:10.14309/ajg.0000000000000719

Cited by 54 publications

(51 citation statements)

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“…Patients infected with SARS-CoV-2 have an incubation period of 3-14 days with a mean period of 5 days (1,5,6). The most common symptoms of COVID-19 include fever, cough, fatigue, and bleeding (2,4,5,(7)(8)(9)(10)(11). Other symptoms include taste changes, headache, abdominal pain, diarrhea, and gastrointestinal bleeding (2,4,5,(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…The most common symptoms of COVID-19 include fever, cough, fatigue, and bleeding (2,4,5,(7)(8)(9)(10)(11). Other symptoms include taste changes, headache, abdominal pain, diarrhea, and gastrointestinal bleeding (2,4,5,(7)(8)(9)(10)(11). If left untreated, COVID-19 can lead to pneumonia, acute respiratory distress syndrome (ARDS), and acute respiratory failure resulting in death (1,5,6).…”

Section: Introductionmentioning

confidence: 99%

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Racial and Gender-Based Differences in COVID-19

Kopel

Perisetti

Roghani

et al. 2020

Front. Public Health

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275

234

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The novel coronavirus disease (COVID-19) has become a global health crisis since its first appearance in Wuhan, China. Current epidemiological studies suggest that COVID-19 affects older patients with multiple comorbidities, such as hypertension, obesity, and chronic lung diseases. The differences in the incidence and severity of COVID-19 are likely to be multifaceted, depending on various biological, social, and economical factors. Specifically, the socioeconomic differences and psychological impact of COVID-19 affecting males and females are essential in pandemic mitigation and preparedness. Previous clinical studies have shown that females are less susceptible to acquire viral infections and reduced cytokine production. Female patients have a higher macrophage and neutrophil activity as well as antibody production and response. Furthermore, in-vivo studies of the angiotensin-converting enzyme 2 (ACE2) showed higher expression in the kidneys of male than female patients, which may explain the differences in susceptibility and progression of COVID-19 between male and female patients. However, it remains unknown whether the expression of ACE2 differs in the lungs of male or female patients. Disparities in healthcare access and socioeconomic status between ethnic groups may influence COVID-19 rates. Ethnic groups often have higher levels of medical comorbidities and lower socioeconomic status, which may increase their risk of contracting COVID-19 through weak cell-mediated immunity. In this article, we examine the current literature on the gender and racial differences among COVID-19 patients and further examine the possible biological mechanisms underlying these differences.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Racial and Gender-Based Differences in COVID-19

Kopel

Perisetti

Roghani

et al. 2020

Front. Public Health

Self Cite

275

234

View full text Add to dashboard Cite

show abstract

“…The severity of their respiratory failure was far more responsible for the mortality risk than that of GIB. The deaths directly related to GIB was uncommon [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report

2020

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Background SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal manifestations, including nausea, diarrhea, and vomiting. Massive gastrointestinal bleeding, however, has rarely been reported. Case presentation We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Although aggressive resuscitation was administered, hematochezia was uncontrolled. The patient rapidly deteriorated, suffered from cardiac arrest, and expired. Conclusions Digestive symptoms could be severe in SARS-CoV-2 infected patients, especially for the high-risk individuals with predisposing conditions. A more thorough protocol for preventing cross-infection through faecal-oral transmission should be implemented in the process of patient care and infection control.

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“…COVID‐19 predominately affects the respiratory system with pneumonia, acute respiratory distress syndrome (ARDS) and multiorgan failure. In addition to respiratory symptoms, non‐respiratory manifestations such as dysgeusia, anorexia, nausea, vomiting, diarrhoea, and abdominal pain are increasingly recognised 3‐5 . World Health Organization (WHO) initially declared the outbreak as a public health emergency of international concern on January 30, 2020, and eventually declared it as a pandemic on March 11, 2020 6,7 .…”

Section: Introductionmentioning

confidence: 99%

“…non-respiratory manifestations such as dysgeusia, anorexia, nausea, vomiting, diarrhoea, and abdominal pain are increasingly recognised. [3][4][5] World Health Organization (WHO) initially declared the outbreak as a public health emergency of international concern on January 30, 2020, and eventually declared it as a pandemic on March 11, 2020. 6,7 This pandemic is unprecedented in terms of rapidity and magnitude of spread throughout the world, including the United States (US).…”

mentioning

confidence: 99%