Gastrointestinal bleeding: The role of radiology

Gómez, S. Quiroga; Lafuente, Mercedes Pérez; Abadia, M Abu-Suboh; Castell-Conesa, Joan

doi:10.1016/j.rxeng.2011.03.003

Cited by 3 publications

(3 citation statements)

References 71 publications

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“…6 Colonoscopy has the highest efficacy in assessing major bleeding events in the lower GI tract. 7 However, accurate diagnosis requires bowel preparation (3–4 hours 2 ) to empty contents of the colon. Additionally, colonoscopy is unable to examine most of the small bowel and introduces risks associated with sedation, perforation and increased bleeding.…”

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confidence: 99%

“…Hospital admissions for GI bleeding in the United States and United Kingdom have been estimated at up to 150 per 100 000 population per year with a mortality rate of 5–10% . GI bleeding is a diagnostic challenge both in its acute presentation, which requires the bleeding site to be located quickly, and in its chronic presentation, which requires repeated examinations to determine its etiology. , Accurate and timely diagnosis is essential in order to reduce morbidity, mortality, length of hospitalization and transfusion requirements. , …”

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confidence: 99%

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Magnetic Particle Imaging for Highly Sensitive, Quantitative, and Safe in Vivo Gut Bleed Detection in a Murine Model

et al. 2017

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Gastrointestinal (GI) bleeding causes more than 300 000 hospitalizations per year in the United States. Imaging plays a crucial role in accurately locating the source of the bleed for timely intervention. Magnetic particle imaging (MPI) is an emerging clinically translatable imaging modality that images superparamagnetic iron-oxide (SPIO) tracers with extraordinary contrast and sensitivity. This linearly quantitative modality has zero background tissue signal and zero signal depth attenuation. MPI is also safe: there is zero ionizing radiation exposure to the patient and clinically approved tracers can be used with MPI. In this study, we demonstrate the use of MPI along with long-circulating, PEG-stabilized SPIOs for rapid in vivo detection and quantification of GI bleed. A mouse model genetically predisposed to GI polyp development (Apc) was used for this study, and heparin was used as an anticoagulant to induce acute GI bleeding. We then injected MPI-tailored, long-circulating SPIOs through the tail vein, and tracked the tracer biodistribution over time using our custom-built high resolution field-free line (FFL) MPI scanner. Dynamic MPI projection images captured tracer accumulation in the lower GI tract with excellent contrast. Quantitative analysis of the MPI images show that the mice experienced GI bleed rates between 1 and 5 μL/min. Although there are currently no human scale MPI systems, and MPI-tailored SPIOs need to undergo further development and evaluation, clinical translation of the technique is achievable. The robust contrast, sensitivity, safety, ability to image anywhere in the body, along with long-circulating SPIOs lends MPI outstanding promise as a clinical diagnostic tool for GI bleeding.

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confidence: 99%

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confidence: 99%

Magnetic Particle Imaging for Highly Sensitive, Quantitative, and Safe in Vivo Gut Bleed Detection in a Murine Model

et al. 2017

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“…Multidetector computed tomographic (CT) angiography with its speed, resolution, multiplanar techniques, and angiographic capabilities allows excellent visualization of both the small and large bowel. 15 It is particularly useful in the investigation of angiodysplasia, with a sensitivity of 70% and specificity of 100%. 16 It is widely considered to be a sensitive, specific, well tolerated and minimally invasive investigation and has replaced conventional angiography for diagnosis of an acute massive bleed (Figure 1).…”

Section: Computerised Tomographic Angiographymentioning

confidence: 99%

Management of Acute Lower Gastrointestinal Bleeding: Principles and Current Practice in the United Kingdom

et al. 2015

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Acute lower gastrointestinal bleeding is a common cause for hospital admission that results in significant morbidity and mortality. The major objectives of all involved in the management of ALGBI patients are to reduce mortality and the need for major surgery. A secondary objective is to prevent unnecessary hospital admission for patients presenting with bleeding that is not lifethreatening. The management of ALGBI has evolved over last decade with the changing modalities of diagnostic facilities. On review of the published literature, there is paucity of randomised control trials in relation to the diagnostic tools and management of ALGBI. The aim of this review is to summarise the principles and current methods available for the diagnosis and treatment of ALGIBand based on the available evidence and the current practice in the United Kingdom, outline an algorithm for the management of ALGIB. Keywords: Lower gastrointestinal bleeding; aetiology; prognosis; management algorithm.

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Cápsula endoscópica y hemorragia digestiva de origen oscuro: ¿importa la forma de presentación?

Martínez‐González

Téllez

Aicart-Ramos

et al. 2015

Gastroenterología y Hepatología

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Gastrointestinal bleeding: The role of radiology

Cited by 3 publications

References 71 publications

Magnetic Particle Imaging for Highly Sensitive, Quantitative, and Safe in Vivo Gut Bleed Detection in a Murine Model

Magnetic Particle Imaging for Highly Sensitive, Quantitative, and Safe in Vivo Gut Bleed Detection in a Murine Model

Management of Acute Lower Gastrointestinal Bleeding: Principles and Current Practice in the United Kingdom

Cápsula endoscópica y hemorragia digestiva de origen oscuro: ¿importa la forma de presentación?

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