Gastrointestinal carcinoid tumors

Varas-Lorenzo, M. J.; Muñoz-Agel, Fernando; Espinós-Pérez, J C; Bardají-Bofill, M

doi:10.4321/s1130-01082010000900004

Cited by 9 publications

(10 citation statements)

References 29 publications

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“…NETs are characterized as slow-growing malignant neoplasms, being epithelial tumors composed of endocrine cells. 20 GI NETs are frequently seen in the colorectal area, especially the rectum. One of the most common primary sites of GI NETs is the rectum within 10 cm of the anus.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of endoscopic resection using the band ligation method for rectal neuroendocrine tumors

Kim

Chung

et al. 2016

Intest Res

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Background/AimsRectal neuroendocrine tumors (NETs) are among the most common of gastrointestinal NETs. Due to recent advances in endoscopy, various methods of complete endoscopic resection have been introduced for small (≤10 mm) rectal NETs. However, there is a debate about the optimal treatment for rectal NETs. In our study, we aimed to evaluate the efficacy and feasibility of endoscopic resection using pneumoband and elastic band (ER-BL) for rectal NETs smaller than 10 mm in diameter.MethodsA total of 55 patients who were diagnosed with rectal NET from January 2004 to December 2011 at Gil Medical Center were analyzed retrospectively. Sixteen patients underwent ER-BL. For comparison, 39 patients underwent conventional endoscopic mucosal resection (EMR).ResultsThere was a markedly lower deep margin positive rate for ER-BL than for conventional EMR (6% [1/16] vs. 46% [18/39], P=0.029). Four patients who underwent conventional EMR experienced perforation or bleeding. However, they recovered within a few days. On the other hand, patients whounderwent endoscopic resection using a pneumoband did not experience any complications. In multivariate analysis, ER-BL (P=0.021) was independently associated with complete resection.ConclusionsER-BL is an effective endoscopic treatment with regards to deep margin resection for rectal NET smaller than 10 mm.

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Section: Discussionmentioning

confidence: 99%

Usefulness of endoscopic resection using the band ligation method for rectal neuroendocrine tumors

Kim

Chung

et al. 2016

Intest Res

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“…Carcinoid syndrome refers to an array of symptoms that occur secondary to carcinoid tumors (35)(36)(37)(38). Carcinoid tumors are discrete, yellow, wellcircumscribed tumors that can occur anywhere along the gastrointestinal tract, as well as in the lung.…”

Section: Carcinoid Syndromementioning

confidence: 99%

“…Clinically, "TIPS" is a pertinent acronym for tricuspid insufficiency, and pulmonary stenosis (due to fibrosis of tricuspid and pulmonary valves). Abdominal pain is often due to desmoplastic reactions within the mesentery, and/or hepatic metastases (35)(36)(37)(38). Interestingly, it is commonly but incorrectly thought that serotonin is the cause of clinical flushing.…”

Section: Carcinoid Syndromementioning

confidence: 99%

“…Usually on CT scan, one will note a spider-like or crab-like change in the mesentery due to the fibrosis from the release of serotonin. Positron electron tomography scans (which can evaluate for increased metabolism of glucose) may also aid in localizing carcinoid tumor primary lesions and/or for confirming metastases (35)(36)(37)(38).…”

Section: Carcinoid Syndromementioning

confidence: 99%

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Diagnosis and treatment of cutaneous paraneoplastic disorders

Velez

Howard

2010

Dermatologic Therapy

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The skin plays a critical role in the detection of internal malignances. Cutaneous signs of these disorders afford clinicians opportunities for early diagnosis and treatment. We aim to succinctly review the recognition, diagnosis, and treatment of selected cutaneous paraneoplastic diseases. Skin disorders that may be associated with paraneoplastic syndromes include: cutaneous metastases, tripe palms, Sweet's syndrome, glucagonoma, Paget's disease and extramammary Paget's disease, acanthosis nigricans, Birt-Hogg-Dube syndrome, basal cell nevus syndrome, Bazex syndrome (acrokeratosis paraneoplastica), carcinoid syndrome, Cowden's disease(multiple hamartoma syndrome), dermatomyositis, erythema gyratum repens, ichthyosis aquisita, von Recklinghausen's disease, pityriasis rotunda, pyoderma gangrenosum, Quincke's edema (angioedema and paraneoplastic uricaria), paraneoplastic pemphigus, Degos' disease, superior vena cava syndrome, Werner's syndrome, diffuse normolipemic plane xanthomas, and yellow nail syndrome. Treatment for these disorders depends on the nature and anatomic distribution of the primary neoplastic process.

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“…The incidence of rectal carcinoids is the highest among gastrointestinal carcinoid tumors (3). The incidences of carcinoids of the rectum, stomach and small bowels have also multiplied (4). The reasons for these epidemiological changes are not yet understood.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of colonoscopy in the diagnosis and treatment of rectal carcinoid tumors with diameter less than 1 cm in 21 patients

et al. 2013

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The aim of this study was to evaluate colonoscopy in the diagnosis and treatment of rectal carcinoid tumors with diameter <1 cm. Elevated lesions with normal mucosal appearance under colonoscopy were identified. Endoscopic ultrasound (EUS) was performed in 16 patients. Lesions diagnosed as rectal carcinoid tumors were resected by endoscopic mucosal resection (EMR). The diagnosis of specimens by EMR was confirmed by pathological examination. Immunohistochemical staining was undertaken and follow-up data were collected. Twenty-two lesions were found among the 21 cases. The majority of these were located within 10 cm of the anal opening. Twenty two cases with rectal carcinoids were diagnosed by EUS under colonoscopy and all cases were verified by pathological examination. The resection rate was 95.5% (21/22). Of the lesions, six were mucosal and 10 were submucosal. Immunohistochemistry was undertaken for carcinoid tumors. Histological patterns of rectal carcinoids revealed solid nests or trabecular patterns. Eleven cases were synaptophysin (SYN)-positive, 8 cases were neurone-specific enolase (NSE)-positive and 5 cases were chromogranin A (CgA)-positive. Colonoscopy combined with EUS is effective in the diagnosis and determination of small rectal carcinoids. Endoscopic treatment is effective for small-sized tumors. Pathology and immunohistochemistry remain the diagnostic gold standard.

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Gastrointestinal carcinoid tumors

Cited by 9 publications

References 29 publications

Usefulness of endoscopic resection using the band ligation method for rectal neuroendocrine tumors

Usefulness of endoscopic resection using the band ligation method for rectal neuroendocrine tumors

Diagnosis and treatment of cutaneous paraneoplastic disorders

Evaluation of colonoscopy in the diagnosis and treatment of rectal carcinoid tumors with diameter less than 1 cm in 21 patients

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