Gastrointestinal Complications in Renal Transplant Recipients: MITOS Study

Gil-Vernet, S.; Amado, Ana; Ortega, Francisco; Alarcón, Antonio; Bernal, Gabriel; Capdevila, Lluís; Crespo, J.F.; Cruzado, Josep M.; Bonis, E. De; Esforzado, Núria; Fernandez, Armida; Franco, A; Hortal, L; Jiménez, Carlos

doi:10.1016/j.transproceed.2007.07.015

Cited by 43 publications

(39 citation statements)

References 16 publications

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“…A multicenter study carried out in Spain reported that diarrhea was the most prevalent gastrointestinal complication during the posttransplant period, affecting 51.5% of the patients . In another study, in Turkey, 12.6% of diarrhea cases in renal transplant recipients were detected, two‐thirds of which occurred during the posttransplant period (>6 months) …”

Section: Introductionmentioning

confidence: 98%

Prevalence of rotavirus and human bocavirus in immunosuppressed individuals after renal transplantation in the Northern Region of Brazil

Castro¹,

Calvet

Sousa

et al. 2019

Journal of Medical Virology

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Immunosuppressive therapy causes severe impairment of host defense and diarrhea is a frequent complication in renal transplant recipients. This study aimed to describe the occurrence of Rotavirus A (RVA) and Human Bocavirus (HBoV) in fecal samples of immunosuppressed patients submitted to renal transplantation during posttransplant follow‐up. A longitudinal study was carried out involving a 25‐patient cohort, selected for kidney transplantation. A total of 126 fecal samples were collected between May 2014 and May 2016. Molecular techniques were used to detect and characterize circulating RVA and HBoV genotypes and statistical analysis were applied to verify the association between epidemiological and clinical characteristics. The prevalence of RVA and HBoV was 24% (6/25) and 40% (10/25), respectively. Among RVA and HBoV positive cases, the majority was female; did not conduct water treatment nor had adequate sewage facilities. The most detected genotypes were RVA G3 (62.5%) and HBoV‐3 (95%). Phylogenetic analysis of HBoV strains indicated that studied samples were similar to those found in Asian and American countries. The present study point out the circulation of these viral agents among immunosuppressed individuals and these findings will enable the construction of new knowledge and care perspectives on the cause of diarrhea in this population.

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Section: Introductionmentioning

confidence: 98%

Prevalence of rotavirus and human bocavirus in immunosuppressed individuals after renal transplantation in the Northern Region of Brazil

Castro¹,

Calvet

Sousa

et al. 2019

Journal of Medical Virology

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show abstract

“…Diarrhea is a frequent condition in the solid organ transplant (SOT) recipient, with a prevalence estimated to be 20-50% following transplant [1][2][3][4][5]. Diarrhea in the organ transplant recipient is a potentially debilitating condition that can lead to severe dehydration, medication toxicity, and transplanted organ rejection, as well as a negative impact on the recipient's quality of life.…”

Section: Introductionmentioning

confidence: 99%

“…Diarrhea in the organ transplant recipient is a potentially debilitating condition that can lead to severe dehydration, medication toxicity, and transplanted organ rejection, as well as a negative impact on the recipient's quality of life. The cause of diarrhea in the transplant population is similar to the nontransplant population, but does have some specific differences; there is a higher incidence of opportunistic infections or rare causes of diarrhea, higher likelihood for the development of chronic infection, medicationinduced diarrhea, and the development of graftversus-host disease (GVHD) (see Table 1) [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Diarrhea in solid organ transplant recipients

Angarone

Ison²

2015

Current Opinion in Infectious Diseases

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“…iarrhea is a frequent complication in kidney transplant recipients (1)(2)(3)(4)(5)(6). Although diarrhea is often considered to be benign, severe episodes can cause dehydration with weight loss, high creatinine levels, and a fluctuation in serum immunosuppressive drug concentrations, resulting in a significant increase in mortality and morbidity and a poorer functional prognosis for the graft (1,2,6).…”

mentioning

confidence: 99%

Microbiological Diagnosis of Severe Diarrhea in Kidney Transplant Recipients by Use of Multiplex PCR Assays

Coste¹,

Vuiblet

Moustapha

et al. 2013

J Clin Microbiol

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Diarrhea is a frequent complication after kidney transplantation, ascribed to adverse effects of the immunosuppressive therapy in case of negative microbiological examination of the stools. The aim of this study was to improve the microbiological diagnosis by implementing molecular tests. Fifty-four severe diarrhea events that occurred in 49 adult kidney transplant recipients from September 2010 to November 2011 were investigated. One or several enteric pathogens were detected in 13 (23%) stool samples using classical microbiological methods versus 39 (72%) for the seven commercially available multiplex PCR assays used retrospectively (P ‫؍‬ 0.006). Interestingly, molecular diagnosis identified 15 multiple infections compared to none using classical techniques. The primary pathogens detected were enteropathogenic Escherichia coli (EPEC) (n ‫؍‬ 15; 38%), Campylobacter spp. (n ‫؍‬ 15; 38%), and Norovirus (n ‫؍‬ 14; 36%). Specificities for Campylobacter and Norovirus infection diagnosis were 75 and 100%, respectively, by comparison to reference methods. Based on molecular findings, a cyclosporine-mycophenolate mofetil combination was identified as a risk factor for developing Norovirus-induced diarrhea. Norovirus infections were also responsible for higher weight loss than all the other causes of diarrhea. In samples from asymptomatic immunocompromised and immunocompetent patients, EPEC but not Norovirus and Campylobacter infections were detected at a frequency similar to that observed in symptomatic kidney transplant recipients. In conclusion, molecular tools significantly improved the detection of single and multiple enteric infections by comparison to classical techniques and could quickly become the key element in the management of severe acute diarrhea in transplant recipients.

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Gastrointestinal Complications in Renal Transplant Recipients: MITOS Study

Cited by 43 publications

References 16 publications

Prevalence of rotavirus and human bocavirus in immunosuppressed individuals after renal transplantation in the Northern Region of Brazil

Prevalence of rotavirus and human bocavirus in immunosuppressed individuals after renal transplantation in the Northern Region of Brazil

Diarrhea in solid organ transplant recipients

Microbiological Diagnosis of Severe Diarrhea in Kidney Transplant Recipients by Use of Multiplex PCR Assays

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