Gastrointestinal dysmotility is associated with altered gut flora and septic mortality in patients with severe systemic inflammatory response syndrome: a preliminary study

Shimizu, Kentaro; Ogura, Hiroshi; Asahara, Takashi; Nomoto, Koji; Morotomi, Masami; Nakahori, Yasutaka; Osuka, Akinori; Yamano, Shuhei; Goto, Miki; Matsushima, Asako; Tasaki, Osamu; Kuwagata, Yasuyuki; Sugimoto, Hisashi

doi:10.1111/j.1365-2982.2010.01653.x

Cited by 76 publications

(46 citation statements)

References 25 publications

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“…Gastrointestinal dysmotility would lead to an ''undrained abscess'' and bacterial translocation [26]. In our non-survivor, it is possible that the bacteremia resulted from a marked increase in intraluminal Pseudomonas.…”

Section: Discussionmentioning

confidence: 92%

Gut microbiota and environment in patients with major burns – A preliminary report

Shimizu

Ogura

Asahara

et al. 2015

Burns

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Section: Discussionmentioning

confidence: 92%

Gut microbiota and environment in patients with major burns – A preliminary report

Shimizu

Ogura

Asahara

et al. 2015

Burns

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“…24,25,29,38 The pooled proportion of FI was 16.6% (range 0 to 24%) with post-pyloric EN compared to 39.7% (range 2-75%) with gastric feeding (P = 0.034).…”

Section: Prevalence Of Fimentioning

confidence: 95%

Definition, prevalence, and outcome of feeding intolerance in intensive care: a systematic review and meta-analysis

Blaser

Starkopf

Kirsimägi

et al. 2014

Acta Anaesthesiol Scand

171

232

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Clinicians and researchers frequently use the phrase 'feeding intolerance' (FI) as a descriptive term in enterally fed critically ill patients. We aimed to: (1) determine what is the most accepted definition of FI; (2) estimate the prevalence of FI; and (3) evaluate whether FI is associated with important outcomes. Systematic searches of peer-reviewed publications using PubMed, MEDLINE, and Web of Science were performed with studies reporting FI extracted. We identified 72 studies defining FI. In 33 studies, the definition was based on large gastric residual volumes (GRVs) together with other gastrointestinal symptoms, while 30 studies relied solely on large GRVs, six studies used inadequate delivery of enteral nutrition (EN) as a threshold, and three studies gastrointestinal symptoms without reference to GRV. The median volume used to define a 'large' GRV was 250 ml (ranges from 75 to 500 ml). The pooled proportion (n = 31 studies) of FI was 38.3% (95% CI 30.7-46.2). Five studies reported outcomes, all of them observed adverse outcome in FI patients. In three studies, respectively, FI was associated with increased mortality and ICU length-of-stay. In summary, FI is inconsistently defined but appears to occur frequently. There are preliminary data indicating that FI is associated with adverse outcomes. A standard definition of FI is required to determine the accuracy of these preliminary data.

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“…The question of whether sepsis or ICU gut dysmotility comes first remains unanswered. Recently, Shimizu et al [53] correlated dysmotility and feeding intolerance with altered bacterial flora in the gut. This work suggests that the alteration in flora leads to significant gastrointestinal dysmotility, which then leads to sepsis.…”

Section: Mechanisms In Sepsismentioning

confidence: 98%

Can the Intestinal Dysmotility of Critical Illness be Differentiated from Postoperative Ileus?

Caddell

Martindale

McClave

et al. 2011

Curr Gastroenterol Rep

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Gastrointestinal dysmotility is commonly noted in the intensive care unit and postoperative settings. Characterized by delayed passage of stool and flatus, nausea, vomiting, and abdominal distention, the condition is associated with nutritional deficiencies, risk of aspiration, and considerable allocation of health care resources. Knowledge of gastrointestinal function in health and illness continues to expand. While the factors that precipitate ileus differ between postoperative and critically ill patients, the two clinical scenarios seem to have similar mechanisms and share many of the same pathophysiologic patterns. By reviewing and comparing the literature on the respective mechanisms and contributing factors generated in these separate clinical settings, a common more comprehensive management strategy may be derived with the potential for newer innovative therapeutic options.

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Gastrointestinal dysmotility is associated with altered gut flora and septic mortality in patients with severe systemic inflammatory response syndrome: a preliminary study

Abstract: Gut flora and organic acids were significantly altered in patients with severe SIRS complicated by gastrointestinal dysmotility, which was associated with higher septic mortality in SIRS patients.

Cited by 76 publications

References 25 publications

Gut microbiota and environment in patients with major burns – A preliminary report

Gut microbiota and environment in patients with major burns – A preliminary report

Definition, prevalence, and outcome of feeding intolerance in intensive care: a systematic review and meta-analysis

Can the Intestinal Dysmotility of Critical Illness be Differentiated from Postoperative Ileus?

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