Gastrointestinal effects of ivermectin treatment in rats infected with Strongyloides venezuelensis

Mendonça, Jalvita C.; Gama, Loyane Almeida; Hauschildt, Andrieli Taise; Corá, Luciana Aparecida; Américo, Madileine Francely

doi:10.1016/j.actatropica.2019.03.024

Cited by 9 publications

(6 citation statements)

References 52 publications

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“…The ACB is a magnetic technique validated to register several parameters of GI motor function in rats (Américo et al, 2010;Dall'Agnol et al, 2017;Mendonça et al, 2019). Magnetic signals generated by magnetic material ingestion are detected by ACB sensor (Br4Science, Brazil) and the signal intensity depends on the amount of magnetic material and its distance from the sensor (Américo et al, 2010).…”

Section: Acb Sensormentioning

confidence: 99%

“…For following up gastrointestinal transit during baru intake in the same animal, alternative methodologies are necessary. Alternate current biosusceptometry (ACB) is an inexpensive, radiation‐free, and noninvasive method previously employed as a reliable technique to record gastrointestinal transit and contractility in rodents (Dall'Agnol et al, ; Mendonça, Gama, Hauschildt, Corá, & Américo, ).…”

Section: Introductionmentioning

confidence: 99%

“…Alternate current biosusceptometry (ACB) is an inexpensive, radiation-free, and noninvasive method previously employed as a reliable technique to record gastrointestinal transit and contractility in rodents (Dall'Agnol et al, 2017;Mendonça, Gama, Hauschildt, Corá, & Américo, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Baru (Dipteryx alataVogel) almond and dairy desserts with baru regulates gastrointestinal transit in rats

Cruz

Gama

Américo

et al. 2019

J Food Process Preserv

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The present study aimed to verify the antioxidant capacity in vitro of baru almond, evaluate the effect of baru intake on gastrointestinal transit and biochemical profile in rats and based on such results characterize the chemical composition of a baru‐enriched dairy dessert and analyze its effect in vivo. It was observed that traditional dairy desserts hastened the gastric emptying and delayed intestinal transit. Ingestion of dairy dessert with baru slowed gastric emptying and avoided the delay of intestinal transit time. After baru consumption, the biochemical profile was extremely favorable with reduced triglycerides and very low‐density lipoprotein, and increased high‐density lipoprotein‐c. The results show that baru almond is a good source of lipids, fibers, and antioxidants (1,179 mg GAE kg−1 sample by ABTS and 8,342 mg GAE kg−1 sample by ferric tripyridyltriazine). The dairy desserts with the highest content of baru normalized gastrointestinal transit compared to traditional dessert, and improved biochemical parameters in rats. Pratical applications In our work, we have developed a new dairy dessert with a Brazilian almond called Baru. The manuscript is significant because it demonstrates the presence of lipids, fibers, and antioxidants in high levels in baru almond and the health benefits associated with the intake of these compounds in dairy desserts.

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Section: Acb Sensormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Baru (Dipteryx alataVogel) almond and dairy desserts with baru regulates gastrointestinal transit in rats

Cruz

Gama

Américo

et al. 2019

J Food Process Preserv

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“…Devi et al reported the positive influence of ivermectin in the treatment of skin problems (habronemosis) in Manipuri ponies caused by intestinal parasites such as Habronema. Mendonça et al presented satisfactory results on the effects of ivermectin in the treatment of mice infected with Strongyloides venezuelensis. Suarez et al investigated the application of ivermectin in the treatment of beef cattle and calves infected with gastrointestinal nematodes.…”

Section: Introductionmentioning

confidence: 99%

Experimental Measurements of the {CO₂ (1) + Acetone (2) + Ivermectin (3)} System at High Pressure

et al. 2019

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For potential application to the controlled release of ivermectin from nanoparticle preparations, this study discloses experimental data on the phase transitions in the CO2, acetone, and ivermectin system subjected to high pressures. The data were acquired via the static synthetic method with a variable-volume view cell in the temperature range of 303.15–333.15 K at pressures up to 10 MPa using three concentrations of ivermectin B1a in acetone (0.029, 0.043, and 0.058 mol·kg–1) and CO2 molar fractions of 0.3–0.9. Vapor–liquid-type phase transitions were observed, characterized as bubbles in the presence or absence of a solid phase. A solid phase was formed for all ivermectin B1a concentrations evaluated in this study. Determination of the region of precipitation of ivermectin is important for identifying the concentration of the acetone/ivermectin mixture where CO2 will act strongly as an antisolvent. Thermodynamic modeling was performed by considering the system as pseudo-ternary based on the low concentration of ivermectin B1a in the system. Thermodynamics modeling using the Peng–Robinson cubic state equation with the van der Waals mixing rule (PR-vdW2) adequately described the experimentally observed trends.

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“…GILLAN; DEVANEY, 2017). A administração de 3 doses consecutivas de ivermectina (200µg/kg por dia) erradicou a totalidade de Strongyloides venezuelensis em ratos, porém prejudicou a função e morfologia gastrointestinal dos animais (MENDONÇA et al, 2019). A ivermectina também está relacionada com doenças hepáticas (VEIT et al, 2006).…”

Section: Eficácia Da Ivermectina Sobre O Número De Ovos E Fêmeas Para...unclassified

Avaliação da atividade anti-helmíntica do óleo essencial de Salvia sagittata (Lamiaceae) sobre Strongyloides venezuelensis (Nematoda, Rhabditoidea)

Noemí Quiñones Morón

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Gastrointestinal effects of ivermectin treatment in rats infected with Strongyloides venezuelensis

Cited by 9 publications

References 52 publications

Baru (Dipteryx alataVogel) almond and dairy desserts with baru regulates gastrointestinal transit in rats

Baru (Dipteryx alataVogel) almond and dairy desserts with baru regulates gastrointestinal transit in rats

Experimental Measurements of the {CO₂ (1) + Acetone (2) + Ivermectin (3)} System at High Pressure

Avaliação da atividade anti-helmíntica do óleo essencial de Salvia sagittata (Lamiaceae) sobre Strongyloides venezuelensis (Nematoda, Rhabditoidea)

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Gastrointestinal effects of ivermectin treatment in rats infected with Strongyloides venezuelensis

Cited by 9 publications

References 52 publications

Baru (Dipteryx alataVogel) almond and dairy desserts with baru regulates gastrointestinal transit in rats

Baru (Dipteryx alataVogel) almond and dairy desserts with baru regulates gastrointestinal transit in rats

Experimental Measurements of the {CO2 (1) + Acetone (2) + Ivermectin (3)} System at High Pressure

Avaliação da atividade anti-helmíntica do óleo essencial de Salvia sagittata (Lamiaceae) sobre Strongyloides venezuelensis (Nematoda, Rhabditoidea)

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Experimental Measurements of the {CO₂ (1) + Acetone (2) + Ivermectin (3)} System at High Pressure