Gastrointestinal Glomus Tumors: A Single Institution, 20-Year Retrospective Study

Zironda, Andrea; Grotz, Travis E.; Folpe, Andrew L.; Thiels, Cornelius A.

doi:10.1016/j.jss.2022.10.070

Cited by 8 publications

(7 citation statements)

References 43 publications

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“…GTs usually occur in the peripheral soft tissue of the extremities, involving the subungual area of fingers and toes. The majority are benign and malignant GTs represent less than 1% of all GTs [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

“…Most GGTs are symptomatic with abdominal pain, GI bleeding or perforation, although some cases have been diagnosed incidentally. Among GGTs, malignant variants are exceedingly rare [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

“…They originate from the submucosa or muscularis propria and develop as masses in the lumen or on the serosa. The most common symptoms are abdominal pain, bleeding and perforation [ 2 ]. There are no specific clinical, radiological or endoscopic features for the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Locally Advanced Glomus Tumor of the Stomach With Synchronous Liver Metastases: Case Report and Literature Review

Frosio,

Petruzziello,

Poiasina

et al. 2023

Cureus

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Gastric glomus tumors (GGTs) are usually rare mesenchymal neoplasms. They are typically benign, with very few metastatic cases reported and no specific guidelines on their management. Here, we present a patient with a locally advanced GGT with synchronous liver metastases. One month after resection of the GGT, emergency laparotomy was required for massive hemoperitoneum due to bleeding from the largest metastasis. Indeed, a dramatic progression of liver metastases was observed in just one month. A wide local excision is considered the treatment of choice for GGTs. In particular, this case report suggests that the resection of any liver metastases should possibly be performed at the same time as the GGT excision and not at a later stage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Locally Advanced Glomus Tumor of the Stomach With Synchronous Liver Metastases: Case Report and Literature Review

Frosio,

Petruzziello,

Poiasina

et al. 2023

Cureus

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“…In contrast-enhanced CT, an improvement is observed in the arterial phase, which also persists in the venous phase. Also, the lesion is well-defined with early and heterogeneous contrast uptake [ 4 , 18 ]. However, sometimes the CT can be exceeded, as happened in the case of Mehmood et al The failure of the imaging diagnosis was attributed to insufficient gastric distension, which did not allow visualization of the lesion [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Glomus cells are modified smooth muscle cells that are small, round, and uniform with well-defined edges, centrally arranged nuclei, and indistinct nucleoli. The elements common to smooth muscle are found in the markers expressed by the glomus cell (caldesmon, smooth muscle actin, calponin), but the difference is the increased production of collagen IV and the absence of desmin [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

A 65-Year-Old Man Presenting to the Emergency Department with Gastric Hemorrhage Caused by a Glomus Tumor

Deacu,

Bosoteanu,

Orășanu

et al. 2023

Am J Case Rep

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Patient: Male, 65-year-old Final Diagnosis: Gastric glomus tumor Symptoms: Gastric hemorrhage Clinical Procedure: — Specialty: Pathology Objective: Rare disease Background: Glomus tumor is a benign but rapidly growing mesenchymal tumor that is a rare in the gastrointestinal tract, can be locally invasive due to its rapid growth, and can result in perforation of a viscus. We report a 65-year-old man presenting as an emergency with gastric hemorrhage and gastric glomus tumor. Case Report: A 65-year-old man came to our hospital for a life-threatening upper digestive hemorrhage. The preoperative examinations (digestive endoscopy without sampling of biopsy fragments and contrast-enhanced computer tomography) led to the presumptive diagnosis of gastrointestinal stromal tumor. Wedge resection of the gastric wall was performed. The histopathological examinations revealed a proliferation of round-oval cells of medium size with a solid disposition and in nests. This proliferation dissected the muscular tunic and caused ulceration of the gastric mucosa. Immunohistochemical tests confirmed the diagnosis of glomus tumor and excluded other diagnoses (neuroendocrine tumor or gastrointestinal stromal tumor). The postoperative evolution was favorable, and at the time of discharge, the biochemical test values normalized. Conclusions: Pathologists are faced with a challenging task due to the deceptive appearance that can be presented by such a rare tumor. Histopathological and immunohistochemical examinations are essential in achieving a precise diagnosis and assessing the biological potential of the glomus tumor. Even if it is a benign tumor, the clinical picture it causes can still be a major risk to the patient’s life. Consequently, ensuring effective case management becomes crucial, as it requires a thorough comprehension of all conditions encompassed in the differential diagnosis.

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Imaging findings of gastric glomus tumors

Sandrasegaran,

Shah,

Thompson

et al. 2024

Abdom Radiol

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Gastrointestinal Glomus Tumors: A Single Institution, 20-Year Retrospective Study

Cited by 8 publications

References 43 publications

Locally Advanced Glomus Tumor of the Stomach With Synchronous Liver Metastases: Case Report and Literature Review

Locally Advanced Glomus Tumor of the Stomach With Synchronous Liver Metastases: Case Report and Literature Review

A 65-Year-Old Man Presenting to the Emergency Department with Gastric Hemorrhage Caused by a Glomus Tumor

Imaging findings of gastric glomus tumors

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