Gastrointestinal health: changes of intestinal mucosa and microbiota in patients with ulcerative colitis and irritable bowel syndrome from PM2.5-polluted regions of Ukraine

Dorofeyev, A. E.; Dorofeyeva, A.A.; Borysov, Arsenii; Tolstanova, Ganna; Borisova, Тatiana

doi:10.1007/s11356-022-22710-9

Environ Sci Pollut Res

2022

DOI: 10.1007/s11356-022-22710-9

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Gastrointestinal health: changes of intestinal mucosa and microbiota in patients with ulcerative colitis and irritable bowel syndrome from PM2.5-polluted regions of Ukraine

A. E. Dorofeyev

A.A. Dorofeyeva

Arsenii Borysov

et al.

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Cited by 11 publications

(1 citation statement)

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“…Upon entering GI, PM can aff ect not only the intestinal cells directly but also the microbiota. Several studies have shown that PM can alter the quantitative ratio and species diversity of the gut microbiota, which, in turn, can lead to dysbiotic disorders [14][15][16] and infl ammatory bowel diseases [17]. Additionally, PM can infl uence metabolic processes occurring in the gut, such as al-tering enzyme activity, short-chain fatty acids, and other microbial metabolites [14,16].…”

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confidence: 99%

Effect of Particulate Matter of Natural and Anthropogenic Origin on Growth Indicators and Sensitivity to Antibiotics of Escherichia coli B906

Korbush,

Serhiichuk,

Yumyna

et al. 2023

Mikrobiol. Z.

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Particulate matter (PM), which is among the main components of polluted air, can contribute to the development of gastrointestinal diseases and alter the composition of gut microbiota and its metabolic properties. Objective. The study focuses on analyzing the influence of different concentrations of PM derived from the combustion of cottonwood (PMC) and medical masks (PMM) on the growth intensity, biofilm formation capability, and antibiotic susceptibility of lactose-positive Escherichia coli strain B906. Methods. The MPA medium was inoculated with a culture of E. coli B906 at a concentration of 105 CFU/mL, followed by the addition of PMC and PMM at concentrations of 18 μg/mL, 36 μg/mL, or 72 μg/mL. The growth intensity was determined by measuring the optical density using a spectrophotometer over a period of 72 h. To determine the number of viable cells and their ability to ferment lactose, seeding on the Endo medium was performed. The biofilm-forming ability was determined on polystyrene plates using a staining and desorption method. The antibiotic susceptibility (ampicillin, levomycetin, meropenem, norfloxacin, and ceftriaxone) was determined using the disc-diffusion method for 24, 48, and 72 h of cultivation. Results. Both PMC and PMM exerted suppressive effects on the growth of E. coli B906: at a concentration of 72 μg/mL, the biomass increase was virtually absent. The number of viable cells on the medium with PMC decreased by 1—2 orders of magnitude at concentrations of 18 μg/mL and 36 μg/mL compared to the control and by 6 orders of magnitude at a concentration of 72 μg/mL. At this concentration, no growth was observed at 48 and 72 h. PMM exerted bacteriostatic effects: when seeded on the Endo medium, the number of viable cells decreased by 1—2 orders of magnitude at concentrations of 18 μg/mL and 36 μg/mL from 24 to 72 h, and by 3—4 orders of magnitude at a concentration of 72 μg/mL. At 48 h cultivation, PMC stimulated biofilm formation at concentrations of 18 μg/mL and 36 μg/mL, while inhibiting it at a concentration of 72 μg/mL. In contrast, PMM reduced the biofilm density at all concentrations. Both types of PM induced resistance to ampicillin, but the effect was stronger for PMM, which also led to resistance to norfloxacin. Conclusions. This study demonstrates that both PMC and PMM have a direct impact on lactose-positive E. coli strain B906, reflected in decreased growth intensity at moderate and high concentrations (36 μg/mL and 72 μg/mL) and increased aggressiveness through reduced enzymatic activity, enhanced biofilm formation, and the emergence of resistance to ampicillin, ceftriaxone, and norfloxacin.

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Effect of Particulate Matter of Natural and Anthropogenic Origin on Growth Indicators and Sensitivity to Antibiotics of Escherichia coli B906

Korbush,

Serhiichuk,

Yumyna

et al. 2023

Mikrobiol. Z.

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Cumulative and lagged effects of varying-sized particulate matter exposure associates with toddlers’ gut microbiota

Qiu

Zang

Fang

et al. 2023

Environmental Pollution

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Similar in vitro response of rat brain nerve terminals, colon preparations and COLO 205 cells to smoke particulate matter from different types of wood

Paliienko¹,

Корбуш²,

Krisanova³

et al. 2022

NeuroToxicology

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Gastrointestinal health: changes of intestinal mucosa and microbiota in patients with ulcerative colitis and irritable bowel syndrome from PM2.5-polluted regions of Ukraine

Cited by 11 publications

References 57 publications

Effect of Particulate Matter of Natural and Anthropogenic Origin on Growth Indicators and Sensitivity to Antibiotics of Escherichia coli B906

Effect of Particulate Matter of Natural and Anthropogenic Origin on Growth Indicators and Sensitivity to Antibiotics of Escherichia coli B906

Cumulative and lagged effects of varying-sized particulate matter exposure associates with toddlers’ gut microbiota

Similar in vitro response of rat brain nerve terminals, colon preparations and COLO 205 cells to smoke particulate matter from different types of wood

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