Gastrointestinal involvement in lymphomatoid granulomatosis: Report of a case and review of the literature

Abstract

Lymphomatoid granulomatosis is a lymphoproliferative process affecting multiple organ systems usually including the lungs. Significant gastrointestinal involvement, however, has rarely been reported. Pathologic examination reveals a vasocentric polymorphous lymphoid infiltrate. A case of lymphomatoid granulomatosis with gastrointestinal manifestations necessitating aggressive surgical intervention is reported. The clinical presentation, pathologic features, and various aspects of therapy of lymphomatoid granulomatosis involving the gastrointestinal tract are discussed.

Lymphomatoid granulomatosis with pulmonary and gastrointestinal involvement

“…Apart from lung involvement, which is almost always present in LYG,3 skin and the central nervous system are often affected 1–8. Gastrointestinal involvement is only found in a very limited number of cases 12 13. LYG often presents between the fourth and six decade and is seen more often in men than in women 14…”

Lymphomatoid Granulomatosis: A Unique Complication of Crohn Disease and Its Treatment in Pediatrics

“…Only 5 reports of LYG with gastrointestinal involvement were found. Large and deep gastroduodenal ulcers with gastrointestinal bleeding and rectal perforation (12,13), ischemic sigmoid colitis (14), and a large bloody and inflammatory mass of the small bowel have been described (15).…”