Gastrointestinal involvement in systemic lupus erythematosus: A systematic review

Frittoli, Renan Bazuco; Vivaldo, Jéssica Fernandes; Costallat, Lílian Tereza Lavras; Appenzeller, Simone

doi:10.1016/j.jtauto.2021.100106

Cited by 34 publications

(38 citation statements)

References 132 publications

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“…Systemic lupus erythematosus (SLE) is a multisystem AID with varied clinical manifestations and a complex pathogenesis [ 72 ]. SLE is the most comorbid of AIDs ( Figure 3 ), and few diseases are as devastating as lupus [ 73 ]. Figure 3 shows that SLE can also accompany arthritis, scleroderma, myositis, inflammatory bowel diseases, and celiac disease [ 74 ].…”

Section: Resultsmentioning

confidence: 99%

Autoimmune Disease Classification Based on PubMed Text Mining

Samuels

Malov

Saha

et al. 2022

JCM

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Autoimmune diseases (AIDs) are often co-associated, and about 25% of patients with one AID tend to develop other comorbid AIDs. Here, we employ the power of datamining to predict the comorbidity of AIDs based on their normalized co-citation in PubMed. First, we validate our technique in a test dataset using earlier-reported comorbidities of seven knowns AIDs. Notably, the prediction correlates well with comorbidity (R = 0.91) and validates our methodology. Then, we predict the association of 100 AIDs and classify them using principal component analysis. Our results are helpful in classifying AIDs into one of the following systems: (1) gastrointestinal, (2) neuronal, (3) eye, (4) cutaneous, (5) musculoskeletal, (6) kidneys and lungs, (7) cardiovascular, (8) hematopoietic, (9) endocrine, and (10) multiple. Our classification agrees with experimentally based taxonomy and ranks AID according to affected systems and gender. Some AIDs are unclassified and do not associate well with other AIDs. Interestingly, Alzheimer’s disease correlates well with other AIDs such as multiple sclerosis. Finally, our results generate a network classification of autoimmune diseases based on PubMed text mining and help map this medical universe. Our results are expected to assist healthcare workers in diagnosing comorbidity in patients with an autoimmune disease, and to help researchers in identifying common genetic, environmental, and autoimmune mechanisms.

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Section: Resultsmentioning

confidence: 99%

Autoimmune Disease Classification Based on PubMed Text Mining

Samuels

Malov

Saha

et al. 2022

JCM

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“…In SLE, lupus peritonitis may present with ascites and gastrointestinal symptoms, such as abdominal pain, diarrhea, bloating, nausea, and anorexia [ 5 ]. Ascites is thought to be caused by vasculitis of the peritoneum, and edema with intestinal swelling contribute to the symptoms [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…In clinical practice, we believe that the first priority is to terminate the pregnancy for maternal safety. Immunotherapy then needs to be intensified, and generally involves steroids [ 5 ]. The administration methods are high-dose or pulse therapy.…”

Section: Discussionmentioning

confidence: 99%

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Massive ascites due to lupus peritonitis in a patient with pre-eclampsia and systemic lupus erythematosus: a case report

Sugai

Suda

Tamegai

et al. 2022

BMC Pregnancy Childbirth

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Background Patients with systemic lupus erythematosus (SLE) are associated with pre-eclampsia. Pre-eclampsia can have systemic manifestations, such as ascites. Lupus peritonitis, a rare condition in patients with SLE, can also cause ascites. Case presentation A 31-year-old woman, primigravida, with SLE had a blood pressure of 170/110 mmHg and proteinuria at 29 weeks of gestation. She was diagnosed with pre-eclampsia. Her blood pressure was stabilized by an antihypertensive drug. At 30 weeks of gestation, a cesarean section was performed for maternal safety because of decreased urine output and massive ascites. Postoperatively, re-accumulation of ascites was observed. On the fourth postoperative day, ascites (approximately 3 L) was discharged from the cesarean section wound. A decrease in serum complement concentrations was observed, and she was diagnosed as having lupus peritonitis. The steroid dose was increased and she recovered well thereafter. Conclusions Ascites occurs in pre-eclampsia and SLE, but determining which of these conditions causes ascites can be difficult. However, careful observation is necessary because of the differences in treatment of these two conditions.

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“…The classical manifestation of this disorder is severe acute abdominal pain. Abdominal pain in SLE can be secondary to peritonitis, pancreatitis, acalculous cholecystitis, gastroenteritis, mesenteric ischemia, intestinal pseudoobstruction, and peptic ulcer disease [ 1 , 3 , 4 ], thus making diagnosis of this rare debilitating condition even more difficult. Lupus enteritis, if remained undiagnosed, can lead to gastrointestinal ischemia, infarction leading to bleeding, and perforation requiring emergent surgical intervention [ 1 ] and is associated with a high mortality rate.…”

Section: Introductionmentioning

confidence: 99%

Dramatic Response of Lupus Enteritis, Nephritis, and Pancytopenia to Plasmapheresis and Rituximab

Aftab

Saleem

Abbas

et al. 2022

Case Reports in Gastrointestinal Medicine

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Background. Although lupus enteritis is a rare manifestation of systemic lupus erythematosus yet results in significant distress. This disorder contributes to diagnostic and therapeutic dilemma leading to enhanced mortality. Case Description. We report a case history of a 29-year-old female who presented with severe abdominal pain, watery stools, and vomiting, and later on, she developed pancytopenia and renal impairment. On intensive workup, diagnosis of lupus-associated enteritis, nephritis, and pancytopenia was discovered. She improved drastically on initiation of plasmapheresis followed by low-dose intravenous rituximab. One year posttreatment, she remained in complete remission. Conclusion. From this case, it can be suggested that in a young female with intractable abdominal pain, the remote possibility of lupus enteritis must be kept in mind. Besides this, plasmapheresis can have a potential role in refractory lupus enteritis. Furthermore, low-dose intravenous rituximab can be a safe and cost-effective treatment option in achieving sustained remission of clinical and laboratory parameters in lupus enteritis.

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Gastrointestinal involvement in systemic lupus erythematosus: A systematic review

Cited by 34 publications

References 132 publications

Autoimmune Disease Classification Based on PubMed Text Mining

Autoimmune Disease Classification Based on PubMed Text Mining

Massive ascites due to lupus peritonitis in a patient with pre-eclampsia and systemic lupus erythematosus: a case report

Dramatic Response of Lupus Enteritis, Nephritis, and Pancytopenia to Plasmapheresis and Rituximab

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