Gastrointestinal Malignancies and Venous Thromboembolic Disease: Clinical Significance and Endovascular Interventions

Li, Xin; Partovi, Sasan; Gadani, Sameer; Martin, Charles E.; Beck, A. David; Vedantham, Suresh

doi:10.1055/s-0040-1716739

Cited by 2 publications

(2 citation statements)

References 69 publications

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“…The mortality rate dramatically increases in cancer patients and is considered the second leading cause of death after progression of the cancer itself [ 2 , 3 ]. In addition to short-term morbidity of VTE in this population, long-term consequences dictated by higher VTE recurrence and major bleeding events have been reported in this population compared to non-cancer VTE patients [ 4 ]. Furthermore, malignancy is considered a strong risk factor for developing VTE with an incidence of 4–20% among cancer patients [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Incidence and Outcomes of Venous Thromboembolisms in Patients Admitted with Different Gastrointestinal Malignancies

Darweesh,

Haddaden,

Fatima

et al. 2024

Gastrointest Tumors

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Introduction: Venous thromboembolism (VTE) is associated with significant morbidity and mortality in cancer patients. Our study compares the mortality in hospitalized VTE patients among the four most common Gastrointestinal (GI) malignancies which includes esophageal, gastric, pancreatic, colorectal cancer. Methods: A retrospective study was conducted utilizing the Nationwide Inpatient Sample database (NIS) from 2016 to 2019. Patients with Venous thromboembolism (VTE) were identified using ICD-10 codes from all primary discharge diagnoses. Only deep venous thrombosis (DVT) and pulmonary embolism (PE) were considered. Patients with VTE were further divided into groups: esophageal cancer, gastric cancer, pancreatic cancer, colorectal cancer, and compared with patients who did not have these malignancies. Adjusted odds ratio (aOR) was calculated using multivariate regression analysis. Results: Among 999,559 patients discharged with a VTE diagnosis, 25,775 (2.6%) had one of the four GI malignancies. Among patients with one of the four included GI malignancy diagnosis, 18,816 (73%) patients had PE and 6,959 (27%) patients had DVT. The study shows that adults admitted to the hospitals for VTE have higher mortality when compared to patients who did not have GI malignancies, with esophageal cancer having the highest inpatient mortality with an aOR of 2.701; 95% Confidence interval (CI) 1.989-3.669, P-value < 0.000. For the remaining GI cancers, gastric cancer had an aOR 1.576; CI 1.094-2.269, P-value 0.015, pancreatic cancer had an aOR of 1.736; 95% CI 1.445-2.085, P-value < 0.000). Patients with colorectal cancer had no significant increase in the odds of mortality with aOR of 1.213; 95% CI 0.988-1.489, P-value 0.066. Conclusions: This study demonstrates that VTE in hospitalized patients with esophageal cancer is associated with greater mortality compared to other GI malignancies.

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Section: Introductionmentioning

confidence: 99%

The Incidence and Outcomes of Venous Thromboembolisms in Patients Admitted with Different Gastrointestinal Malignancies

Darweesh,

Haddaden,

Fatima

et al. 2024

Gastrointest Tumors

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“…1 Along with the high filter placement, there has been a growing number of filter complications, including filter fracture, migration, tilting, and long-term complications such as postthrombotic syndrome. 2,3 Among those, filter tilt often occurs during the immediate periprocedure timeframe and is associated with a decrease in filtering efficiency and an increase in retrieval difficulties. Many methods have been utilized to minimize filter tilt and one possible option is the use of the over-the-wire (OTW) technique, during which the OptionElite filter (Argon Medical Devices, Plano, TX) is deployed over a 0.035-inch guidewire.…”

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confidence: 99%