Gastrointestinal Malignancies in Infancy, Childhood, and Adolescence

Goldthorn, Jane F.; Canizaro, Peter C.

doi:10.1016/s0039-6109(16)43996-4

Cited by 44 publications

(32 citation statements)

References 85 publications

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“…Our patient is a new case of de-novo occurrence such as those that have been sporadically reported in the first and second decades of the life [1,6,9]. The lack of any kind of causative information and the normal histological findings of gastric mucosa outside the tumor suggest that our case was a new primary gastric carcinoma, which may be classified as de-novo occurrence, and which ended fatally 4 months after diagnosis in spite of complete resection and administered chemotherapy.…”

Section: Discussionmentioning

confidence: 75%

“…Gastric adenocarcinomas are not common among gastric malignancies [1] and they may develop in three ways in the pediatric age group: de novo, as part of a polyposis syndrome, and following treatment of a gastric lymphoma [1]. Our patient is a new case of de-novo occurrence such as those that have been sporadically reported in the first and second decades of the life [1,6,9].…”

Section: Discussionmentioning

confidence: 83%

“…In most parts of the world, adenocarcinoma of the stomach is primarily a disease of older individuals, and is rare under the age of 30 years [1]. Although nearly 10% of gastric cancer cases are found in patients younger than age 41 years [7], gastric cancer is exceedingly rare in children under the age of 5 years.…”

Section: Discussionmentioning

confidence: 99%

“…Primary gastric carcinomas are extremely rare in childhood, although gastrointestinal malignancies represent approximately 5% of all pediatric neoplasms [1]. A brief literature review showed around ten cases reported in patients under the age of 5 years since 1978 [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Primary gastric adenocarcinoma in a 2.5-year-old girl

et al. 2002

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anemia (hemoglobin [Hb], 2.6 g/l; hematocrit [Htc], 7) of the child was treated. Routine laboratory test results were nonspecific. Serum tumor markers, such as carcinoembryonic antigen alpha-fetoprotein, antigen (CEA), and human chorionic gonadotropin (HCG) were negative. Her blood group was B rh (ϩ). She came from a family of six children living in a rural mountain area. The family history of the child was not informative. There was no history of childhood tumor or gastrointestinal malignancies in the family and close relatives. However, several gastrointestinal infections had frequently occurred in the family.At surgery, we found a large, irregularly circumferential solid mass, extending from the corpus to 1.5 cm below the pylorus, originating from the lesser curvature. There was a firm extension to the omentum and the abdominal wall. The stomach outside the mass invasion had a normal appearance. The liver and other intraperitoneal organs appeared free of gross disease. Complete resection of the mass and a subtotal gastrectomy (80%) was performed. A retrocolic gastrojejunostomy and omentectomy, removing all gross disease, completed the procedure. The resected specimen was a dark brown mass, 12 ϫ 7 ϫ 7cm in diameter, which had almost obliterated the gastric lumen. The intraluminal part of the mass had a soft, grayish, highly fragile nodular form in which gross mucous areas were remarkable. Lymph nodes in the area appeared normal, and representative biopsies were free of tumor.Microscopically, tumoral infiltration through the gastric wall was seen. We observed glandular structures presenting atypical epithelial cells, atypical mitosis, abundant eosinophylic cytoplasm, and highly hyperchromatic cells, and some large extracellular mucin-containing areas among these structures. Immunochemical staining of the specimen for epithelial membrane antigen (EMA) was positive, and staining for vimentin, smooth muscle actin, and alpha-fetoprotein was negative. The histological diagnosis, according Abstract Primary gastric adenocarcinoma is extremely rare in children. Here, we report an additional case of primary adenocarcinoma, located at the lesser curvature in a girl at the age of 2.5 years. She had no family history and no apparent underlying cause for the tumor. She died 4 months after admission despite complete resection of the mass and chemotherapy.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary gastric adenocarcinoma in a 2.5-year-old girl

et al. 2002

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“…Although gastric carcinoma is extremely rare in children representing only 0.05% of all gastrointestinal malignancies, its incidence increases with age (Goldthorn et al,1986). Recently a case of gastric adenocarcinoma presenting with gastric outlet obstruction in a child was reported by Al Hussaini (2014).…”

Section: Pylori Infection and Gastric Lesions In Paediatric Casesmentioning

confidence: 99%