Gastrointestinal manifestations of COVID-19: results from a European centre

Leal, Tiago; Costa, Emanuel; Arroja, Bruno; Gonçalves, Raquel; Alves, Joana

doi:10.1097/meg.0000000000002152

Cited by 22 publications

(31 citation statements)

References 21 publications

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“…Although there were reports of COVID-19 patients exhibiting GI symptoms, high rates of fever (>38.5°C), fatigue, shortness of breath and headache ( 56 ), a study by Lean et al, published during preparation of our manuscript, showed that patients with digestive symptoms experienced less severe disease ( 66 ) as defined by the need for mechanical ventilation, ICU admission or death, which is further supported by similar observation in other studies ( 55 , 67 , 68 ). Additionally, patients with digestive symptoms had a significantly longer time from onset to admission than patients without digestive symptoms ( 55 , 68 ), necessitating a high level of caution in reaching an early diagnosis and setup of necessary infection control measures to control the transmission rate.…”

Section: Covid-19 and Microbiomementioning

confidence: 72%

A Microbiome-Driven Approach to Combating Depression During the COVID-19 Pandemic

Ghannoum

Ford²,

Gamal

et al. 2021

Front. Nutr.

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The significant stressors brought about and exacerbated by COVID-19 are associated with startling surges in mental health illnesses, specifically those related to depressive disorders. Given the huge impact of depression on society, and an incomplete understanding of impactful therapeutics, we have examined the current literature surrounding the microbiome and gut-brain axis to advance a potential complementary approach to address depression and depressive disorders that have increased during the COVID-19 pandemic. While we understand that the impact of the human gut microbiome on emotional health is a newly emerging field and more research needs to be conducted, the current evidence is extremely promising and suggests at least part of the answer to understanding depression in more depth may lie within the microbiome. As a result of these findings, we propose that a microbiome-based holistic approach, which involves carefully annotating the microbiome and potential modification through diet, probiotics, and lifestyle changes, may address depression. This paper's primary purpose is to shed light on the link between the gut microbiome and depression, including the gut-brain axis and propose a holistic approach to microbiome modification, with the ultimate goal of assisting individuals to manage their battle with depression through diet, probiotics, and lifestyle changes, in addition to offering a semblance of hope during these challenging times.

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Section: Covid-19 and Microbiomementioning

confidence: 72%

A Microbiome-Driven Approach to Combating Depression During the COVID-19 Pandemic

Ghannoum

Ford²,

Gamal

et al. 2021

Front. Nutr.

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show abstract

“…Therefore, we further reviewed the literatures in our analysis. Among the literatures that had data on the age of patients with/without GI symptoms, all of the European and American literatures (n = 8 of 8, 100%) [ 15 , 19 , 33 , 34 , 37 , 45 , 46 , 49 ] reported that patients with GI symptoms were younger than those without. And OR values were < 1 in 7 [ 15 , 19 , 33 , 34 , 37 , 46 , 49 ] of these 8 literatures.…”

Section: Resultsmentioning

confidence: 99%

Are gastrointestinal symptoms associated with higher risk of Mortality in COVID-19 patients? A systematic review and meta-analysis

Wang

Zhang

et al. 2022

BMC Gastroenterol

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Background Gastrointestinal symptoms have been reported in patients with COVID-19. Several clinical investigations suggested that gastrointestinal symptoms were associated with disease severity of COVID-19. However, the relevance of gastrointestinal symptoms and mortality of COVID-19 remains largely unknown. We aim to investigate the relationship between gastrointestinal symptoms and COVID-19 mortality. Methods We searched the PubMed, Embase, Web of science and Cochrane for studies published between Dec 1, 2019 and May 1, 2021, that had data on gastrointestinal symptoms in COVID-19 patients. Additional literatures were obtained by screening the citations of included studies and recent reviews. Only studies that reported the mortality of COVID-19 patients with/without gastrointestinal symptoms were included. Raw data were pooled to calculate OR (Odds Ratio). The mortality was compared between patients with and without gastrointestinal symptoms, as well as between patients with and without individual symptoms (diarrhea, nausea/vomiting, abdominal pain). Results Fifty-three literatures with 55,245 COVID-19 patients (4955 non-survivors and 50,290 survivors) were included. The presence of GI symptoms was not associated with the mortality of COVID-19 patients (OR=0.88; 95% CI 0.71–1.09; P=0.23). As for individual symptoms, diarrhea (OR=1.01; 95% CI 0.72–1.41; P=0.96), nausea/vomiting (OR=1.16; 95% CI 0.78–1.71; P=0.46) and abdominal pain (OR=1.55; 95% CI 0.68–3.54; P=0.3) also showed non-relevance with the death of COVID-19 patients. Conclusions Gastrointestinal symptoms are not associated with higher mortality of COVID-19 patients. The prognostic value of gastrointestinal symptoms in COVID-19 requires further investigation.

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“…The study by Leal et al [ 8 ], evaluating 234 European patients with digestive symptoms, also had a more favorable and non-severe prognosis.…”

Section: To the Editormentioning

confidence: 99%

Gastrointestinal symptoms in patients with COVID-19: Is there a relationship with mortality and new variations of SARS-CoV-2?

Ribeiro¹,

Moura²

2021

WJG

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Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although, respiratory symptoms are typical the digestive system is also a susceptible target with gastrointestinal symptoms present even in the absence of respiratory symptoms. The gastrointestinal symptoms of COVID-19 include diarrhea, abdominal pain, anorexia, and nausea among other symptoms. Some questions that remain to be answered include: Do patients with gastrointestinal symptoms have a higher mortality? SARS-CoV-2 variants are already a global reality: Do these variants present with a greater prevalence of gastrointestinal symptoms? Do patients with these symptoms warrant more intensive care unit care?

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Gastrointestinal manifestations of COVID-19: results from a European centre

Cited by 22 publications

References 21 publications

A Microbiome-Driven Approach to Combating Depression During the COVID-19 Pandemic

A Microbiome-Driven Approach to Combating Depression During the COVID-19 Pandemic

Are gastrointestinal symptoms associated with higher risk of Mortality in COVID-19 patients? A systematic review and meta-analysis

Gastrointestinal symptoms in patients with COVID-19: Is there a relationship with mortality and new variations of SARS-CoV-2?

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