Gastrointestinal Manifestations of Cowdenʼs Disease

Hizawa, Kazuoki; Iida, Masahiro; Matsumoto, Takao; Kohrogi, Norio; Suekane, Hiroshi; Yao, Tsuneyoshi; Fujishima, M

doi:10.1097/00004836-199401000-00005

Cited by 47 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mucosal neural polyps with similar features to our case have been recently described by Gibson et al [12] , and we agree with author's proposal of the new and interim designation of "mucosal Schwann cell hamartoma" for this lesion, to avoid confusion with the gastrointestinal neural lesions that have significant associations with inherited syndromes [15][16][17] . Our case should not be considered as an intramucosal schwannoma, although qualitatively composed exclusively of Schwann cells, because it presents peculiar histological features: the lack of circumscription, the absence of a peripheral lymphoid cuff [5] , and crypt entrapment.…”

Section: Discussionsupporting

confidence: 93%

Mucosal Schwann cell “Hamartoma”: A new entity?

Pasquini¹,

Baiocchini²,

Falasca³

et al. 2009

WJG

View full text Add to dashboard Cite

Schwannoma is a well-described, benign nerve sheath tumor of the soft tissue, but is rare in the gastrointestinal tract. Gastrointestinal schwannomas are often incidentally discovered as small polypoid intraluminal lesions. In this report, we describe the clinicopathologic and immunohistochemical features of a distinctive neural mucosal polyp composed of a diffuse cellular proliferation of uniform bland spindled cells in the lamina propria that entraps the colonic crypts. Immunohistochemical analysis revealed strong and diffuse positivity for the S-100 protein. To avoid confusion of these solitary colorectal polyps containing pure spindled Schwann cell proliferation in the lamina propria with neural lesions that have significant association with inherited syndromes, it is better to use the designation "mucosal Schwann hamartoma".

show abstract

Section: Discussionsupporting

confidence: 93%

Mucosal Schwann cell “Hamartoma”: A new entity?

Pasquini¹,

Baiocchini²,

Falasca³

et al. 2009

WJG

View full text Add to dashboard Cite

show abstract

“…Patients with such polyps should be examined for various genetic syndromes associated with gastro-intestinal polyps, including Peutz-Jeghers syndrome, Cowden syndrome, and Cronkhite-Canada syndrome. 5 Histology shows Helicobacter pylori-negative, nonspecific lymphoid hyperplasia. Diffuse oesophageal glycogenic acanthosis has seldom been seen in young adults.…”

Section: Discussionmentioning

confidence: 99%

Atypical focal cortical dysplasia in a patient with Cowden syndrome

et al. 2014

View full text Add to dashboard Cite

“…13 Furthermore, the presence of gastrointestinal tract ganglioneuromas has been documented in more than 15 individuals with PHTS. 5,23,32,[41][42][43][44][45][46][47][48][49] Last, corneal nerve hypertrophy (a finding stated by some to be pathognomonic for multiple endocrine neoplasia type 2B [MEN2B]) 50,51 has been noted in approximately one third of patients with BRRS. 9,10,12 The patient described herein developed multiple mucocutaneous neuromas as a consequence of a novel heterozygous germline nonsense mutation in PTEN.…”

Section: Discussionmentioning

confidence: 99%