Gastrointestinal Manifestations of Hereditary Hemorrhagic Telangiectasia (HHT): A Systematic Review of the Literature

Jackson, Samuel B.; Villano, Nicholas; Benhammou, Jihane N.; Lewis, Michael; Pisegna, Joseph R.; Padua, David

doi:10.1007/s10620-017-4719-3

Cited by 92 publications

(49 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many cases of anemia are misattributed to overt epistaxis instead of attributing them to GI bleeding among patients with HHT [16,31]. In fact, we have not found significant differences in epistaxis severity measured by the ESS between patients with and without GI involvement.…”

Section: Discussioncontrasting

confidence: 65%

Gastrointestinal Bleeding in Patients with Hereditary Hemorrhagic Telangiectasia: Risk Factors and Endoscopic Findings

Mora-Luján

Iriarte

Alba

et al. 2019

JCM

View full text Add to dashboard Cite

Background: We aimed to describe risk factors for gastrointestinal (GI) bleeding and endoscopic findings in patients with hereditary hemorrhagic telangiectasia (HHT). Methods: This is a prospective study from a referral HHT unit. Endoscopic tests were performed when there was suspicion of GI bleeding, and patients were divided as follows: with, without, and with unsuspected GI involvement. Results: 67 (27.9%) patients with, 28 (11.7%) patients without, and 145 (60.4%) with unsuspected GI involvement were included. Age, tobacco use, endoglin (ENG) mutation, and hemoglobin were associated with GI involvement. Telangiectases were mostly in the stomach and duodenum, but 18.5% of patients with normal esophagogastroduodenoscopy (EGD) had GI involvement in video capsule endoscopy (VCE). Telangiectases ≤ 3 mm and ≤10 per location were most common. Among patients with GI disease, those with hemoglobin < 8 g/dL or transfusion requirements (65.7%) were older and had higher epistaxis severity score (ESS) and larger telangiectases (>3 mm). After a mean follow-up of 34.2 months, patients with GI involvement required more transfusions and more emergency department and hospital admissions, with no differences in mortality. Conclusions: Risk factors for GI involvement have been identified. Patients with GI involvement and severe anemia had larger telangiectases and higher ESS. VCE should be considered in patients with suspicion of GI bleeding, even if EGD is normal. Author Contributions: Conceptualization: J.M.M.-L. and A.R.-M.; data curation: J.M.M.-L., A.I., A.B., P.C. and A.R.-M.; formal analysis: J.M.M.-L., A.I., P.C. and A.R.-M.; investigation: J.M.Mmethodology: J.M.M.-L. and A.R.-M.; supervision: J.R., J.C. and A.R.-M.; validation: J.M.M.-L., A.I., E.A., M.Á.S.-C., A.B., P.C., F.C., J.R., J.C. and A.R.-M.; visualization: J.M.M.-L., E.A., F.C. and A.R.-M.; writing-original draft preparation: J.M.M.-L., A.I., E.A., M.Á.S.-C., A.B., P.C., F.C. and A.R.-M.; writing-review and editing: J.M.M.-L., J.R., J.C. and A.R.-M; funding acquisition: A.R.-M. All authors have read and agreed to the published version of the manuscript.

show abstract

Section: Discussioncontrasting

confidence: 65%

Gastrointestinal Bleeding in Patients with Hereditary Hemorrhagic Telangiectasia: Risk Factors and Endoscopic Findings

Mora-Luján

Iriarte

Alba

et al. 2019

JCM

View full text Add to dashboard Cite

show abstract

“…Telangiectasias in the gastrointestinal tract are present in more or less 15 to 30% of the patients, typically after the age of 40 16 . They are present in the stomach, the small and large intestine.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Hereditary Hemorrhagic Telangiectasia: The ENT point of view

Eloy

Muşat

2020

Romanian Journal of Rhinology

View full text Add to dashboard Cite

Hemorrhagic Hereditary Telangiectasia (HHT) disease, also called Osler-Weber-Rendu (OWR) disease, is a rare and underdiag-nosed genetic disorder characterized by a multisystemic vascular dysplasia. Nosebleeds, acute or chronic digestive tract bleeding and various problems due to the involvement of major organs (liver, lungs, brain) characterize the disease.Although it was described at the beginning of the 20th century, many patients, GPs and specialists still ignore the disease, its morbidities and the modalities of the treatment.That is the reason why the authors have decided to publish this review on this familiar, evolving and potentially life-threatening disease, whose management can be sometimes a real nightmare for the clinician.

show abstract

“…GI bleeding can be stopped by either resection or embolectomy. Unfortunately, HHT is not preventable [13].…”

Section: Hereditary Hemorrhagic Telangiectasia (Hht)mentioning

confidence: 99%

Selected Disorders of the Blood and Hematopoietic System

Emmet¹,

Jagadish²,

Malik³

et al. 2020

Family Medicine

View full text Add to dashboard Cite

Gastrointestinal Manifestations of Hereditary Hemorrhagic Telangiectasia (HHT): A Systematic Review of the Literature

Cited by 92 publications

References 47 publications

Gastrointestinal Bleeding in Patients with Hereditary Hemorrhagic Telangiectasia: Risk Factors and Endoscopic Findings

Gastrointestinal Bleeding in Patients with Hereditary Hemorrhagic Telangiectasia: Risk Factors and Endoscopic Findings

Hereditary Hemorrhagic Telangiectasia: The ENT point of view

Selected Disorders of the Blood and Hematopoietic System

Contact Info

Product

Resources

About