Gastrointestinal motility in people with type 1 diabetes and peripheral neuropathy. Reply to Marathe CS, Rayner CK, Jones KL, et al [letter]

Farmer, Adam D.; Pedersen, Anne Grave; Brock, Birgitte; Jakobsen, Poul Erik; Karmisholt, Jesper; Mohammed, Sahar; Scott, S. M.; Drewes, Asbjørn Mohr; Brock, Christina

doi:10.1007/s00125-017-4414-0

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…More specifically, according to Jung et al [32], out of 100 000 people, approximately 38 females and 10 males suffer from idiopathic gastroparesis. The prevalence of diabetes-induced gastroparesis in the US is even higher, as 165 000 patients with type 1 diabetes and 2.1 million patients with type 2 diabetes are currently seeking treatment [33].…”

Section: Gastroparesis and The Pyloric Sphinctermentioning

confidence: 99%

Bioengineering of the digestive tract: approaching the clinic

et al. 2021

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The field of regenerative medicine is developing technologies that, in the near future, will offer alternative approaches to either cure diseases affecting the gastrointestinal tract or slow their progression by leveraging the intrinsic ability of our tissues and organs to repair after damage. This article will succinctly illustrate the three technologies that are closer to clinical translation-namely, human intestinal organoids, sphincter bioengineering and decellularization, whereby the cellular compartment of a given segment of the digestive tract is removed to obtain a scaffold consisting of the extracellular matrix. The latter will be used as a template for the regeneration of a functional organ, whereby the newly generated cellular compartment will be obtained from the patient's own cells. Although clinical application of this technology is approaching, product development challenges are being tackled to warrant safety and efficacy.

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Section: Gastroparesis and The Pyloric Sphinctermentioning

confidence: 99%

Bioengineering of the digestive tract: approaching the clinic

et al. 2021

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“…Neurodegeneration of the autonomic nervous system causes disturbances in the neuro-signaling of the organ–brain nexus, responsible for upholding homeostasis. 10 , 11 Dysautonomia reveals many symptoms (e.g., difficulty in tight glucose control, 12 gastroenteropathy, 13 – 15 urogenital challenges, 16 , 17 orthostatic hypotension, 18 and cardiac arrhythmias, myocardial infarction, and sudden death 19 , 20 ). The concluding diagnosis needs abnormal cardiovascular autonomic reflex testing 6 , 11 or decreased heart rate variability.…”

Section: Introductionmentioning

confidence: 99%

The Retinal Nerve Fiber Layer Thickness Is Associated with Systemic Neurodegeneration in Long-Term Type 1 Diabetes

Brock

Wegeberg

Nielsen

et al. 2023

Trans. Vis. Sci. Tech.

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Purpose To determine whether the retinal nerve fiber layer thickness can be used as an indicator for systemic neurodegeneration in diabetes. Methods We used existing data from 38 adults with type 1 diabetes and established polyneuropathy. Retinal nerve fiber layer thickness values of four scanned quadrants (superior, inferior, temporal, and nasal) and the central foveal thickness were extracted directly from optical coherence tomography. Nerve conduction velocities were recorded using standardized neurophysiologic testing of the tibial and peroneal motor nerves and the radial and median sensory nerves, 24-hour electrocardiographic recordings were used to retrieve time- and frequency-derived measures of heart rate variability, and a pain catastrophizing scale was used to assess cognitive distortion. Results When adjusted for hemoglobin A1c, the regional thickness of the retinal nerve fiber layers was (1) positively associated with peripheral nerve conduction velocities of the sensory and motor nerves (all P < 0.036), (2) negatively associated with time and frequency domains of heart rate variability (all P < 0.033), and (3) negatively associated to catastrophic thinking (all P < 0.038). Conclusions Thickness of the retinal nerve fiber layer was a robust indicator for clinically meaningful measures of peripheral and autonomic neuropathy and even for cognitive comorbidity. Translational Relevance The findings indicate that the thickness of the retinal nerve fiber layer should be studied in adolescents and people with prediabetes to determine whether it is useful to predict the presence and severity of systemic neurodegeneration.

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