Gastrointestinal Mucosa: The Target Site of Mucoadhesive Microspheres, A Review

Zaman, Muhammad; Sajid, Nayab; Rehman, Atta Ur

doi:10.1002/adv.21550

Cited by 5 publications

(4 citation statements)

References 63 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gel microsphere and solid microsphere made of alginate can be obtained readily, serving as a delivery system for drugs, growth factors, cells, etc. [ 60 , 61 , 62 , 63 ]. Generally, alginate gel-microspheres are prepared by ionic crosslinking under aqueous conditions, which are suitable for the encapsulation of cells, growth factors and biologically active proteins [ 64 , 65 , 66 ].…”

Section: Preparation and Processing Technology Of Alginatesmentioning

confidence: 99%

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

2021

View full text Add to dashboard Cite

Alginates are naturally occurring polysaccharides extracted from brown marine algae and bacteria. Being biocompatible, biodegradable, non-toxic and easy to gel, alginates can be processed into various forms, such as hydrogels, microspheres, fibers and sponges, and have been widely applied in biomedical field. The present review provides an overview of the properties and processing methods of alginates, as well as their applications in wound healing, tissue repair and drug delivery in recent years.

show abstract

Section: Preparation and Processing Technology Of Alginatesmentioning

confidence: 99%

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

2021

View full text Add to dashboard Cite

show abstract

“…First, the solution is atomized and mixed with a drying gas, the solvent is evaporated from the solution, and the powder obtained is separated from the drying gas [62,63]. One of the main reasons supporting the use of this method in structuring microspheres is because of its low cost, reproducibility, and simplicity [64]. In addition, the characteristics of the microspheres can be optimized, heat-sensitive materials can be encapsulated, and their microbiological quality is ensured [64,65].…”

Section: Spray Dryingmentioning

confidence: 99%

“…One of the main reasons supporting the use of this method in structuring microspheres is because of its low cost, reproducibility, and simplicity [64]. In addition, the characteristics of the microspheres can be optimized, heat-sensitive materials can be encapsulated, and their microbiological quality is ensured [64,65].…”

Section: Spray Dryingmentioning

confidence: 99%

See 1 more Smart Citation

Pectin Microspheres: Synthesis Methods, Properties, and Their Multidisciplinary Applications

2022

View full text Add to dashboard Cite

There is great contemporary interest in using cleaner technologies through green chemistry and utilizing biopolymers as raw material. Pectin is found on plant cell walls, and it is commonly extracted from fruit shells, mostly apples or citrus fruits. Pectin has applications in many areas of commercial relevance; for this reason, it is possible to find available information about novel methods to transform pectin and pursuing enhanced features, with the structuring of biopolymer microspheres being highly cited to enhance its activity. The structuring of polymers is a technique that has been growing in recent decades, due to its potential for diverse applications in various fields of science and technology. Several techniques are used for the synthesis of microspheres, such as ionotropic gelation, extrusion, aerosol drying, or emulsions, with the latter being the most commonly used method based on its reproducibility and simplicity. The most cited applications are in drug delivery, especially for the treatment of colon diseases and digestive-tract-related issues. In the industrial field, it is used for protecting encapsulated compounds; moreover, the environmental applications mainly include the bioremediation of toxic substances. However, there are still many possibilities for expanding the use of this biopolymer in the environmental field.

show abstract

Overcoming T. gondii infection and intracellular protein nanocapsules as biomaterials for ultrasonically controlled drug release

Paniwnyk

2017

Biomater. Sci.

View full text Add to dashboard Cite

One of the pivotal matters of concern in intracellular drug delivery is the preparation of biomaterials containing drugs that are compatible with the host target. Nanocapsules for oral delivery are found to be suitable candidates for targeting Toxoplasma gondii (T. gondii), a maneuvering and smart protozoic parasite found across Europe and America that causes a subtle but deadly infection. To overcome this disease, there is much potential of integrating protein-based cells into bioinspired nanocompartments such as via biodegradable cross-linked disulfide polyelectrolyte nanoparticles. The inner membrane vesicle system of these protein-drugs is not as simple as one might think. It is a complex transport network that includes sequential pathways, namely, endocytosis, exocytosis and autophagy. Unfortunately, the intracellular trafficking routes for nanoparticles in cells have not been extensively and intensively investigated. Hence, there lies the need to create robust protein nanocapsules for precise tracing and triggering of drug release to combat this protozoic disease. Protein nanocapsules have the advantage over other biomaterials due to their biocompatibility, use of natural ingredients, non-invasiveness, patient compliance, cost and time effectiveness. They also offer low maintenance, non-toxicity to healthy cells and a strictly defined route toward intracellular elimination through controlled drug delivery within the therapeutic window. This review covers the unprecedented opportunities that exist for constructing advanced nanocapsules to meet the growing needs arising from many therapeutic fields. Their versatile use includes therapeutic ultrasound for tumor imaging, recombinant DNA, ligand and functional group binding, the delivery of drugs and peptides via protein nanocapsules and polyelectrolytes, ultrasound-(US)-aided drug release through the gastrointestinal (GI) tract, and the recent progress in targeting tumor cells and a vast range of cancer therapies. This review also outlines the limitations of current technologies and the directions of future outlook.

show abstract

Gastrointestinal Mucosa: The Target Site of Mucoadhesive Microspheres, A Review

Cited by 5 publications

References 63 publications

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

Pectin Microspheres: Synthesis Methods, Properties, and Their Multidisciplinary Applications

Overcoming T. gondii infection and intracellular protein nanocapsules as biomaterials for ultrasonically controlled drug release

Contact Info

Product

Resources

About