2009
DOI: 10.1007/s00401-009-0527-y
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Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group

Abstract: The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or persistent visceral dilatation. Whilst sensorimotor abnormalities have been demonstrated by a variety of methods in these cond… Show more

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Cited by 199 publications
(258 citation statements)
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References 151 publications
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“…2009 Working Group and is primarily based on hematoxylin-eosin (HE) stained sections [1]. New 4 µm thick sections were prepared from all of the cases for this study.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…2009 Working Group and is primarily based on hematoxylin-eosin (HE) stained sections [1]. New 4 µm thick sections were prepared from all of the cases for this study.…”
Section: Methodsmentioning
confidence: 99%
“…Gastrointestinal dysmotility syndrome (GIDS) can be the consequence of diseases involving the enteric nervous system (enteric neuropathies) or based on abnormalities of the enteric smooth muscles (myopathies) [1] . Gastrointestinal (GI) functional disturbances are observed in subjects without any additional complaints but also in subjects with neurodegenerative diseases (ND) [2].…”
Section: Introductionmentioning
confidence: 99%
“…International Working Group, 11 diagnostic rectal biopsies should be taken 1 to 2.5 cm proximal to anorectal squamocolumnar junction, should measure at least 3 mm, and should include at least one-third of the submucosa.…”
Section: According To a Recent Consensus Article By The Gastro 2009mentioning
confidence: 99%
“…The biopsy specimen should measure at least 3 mm and a minimum of a third of the biopsy should include submucosa. 11 Inadequate biopsies may lead to additional RSB or full-thickness rectal biopsies, adding cost, trauma, and risk to the patient. Calretinin immunostain is of particular interest in inadequate biopsies because submucosa is not necessary for reliable interpretation.…”
mentioning
confidence: 99%
“…10,11 The case documented here exhibits smooth muscle abnormalities that required immunohistochemistry and electron microscopy to characterize, emphasizing the importance of adjunctive diagnostics, including histochemical, immunohistochemical, and ultrastructural techniques ( Table 1). The underlying pathogenic mechanism is yet to be determined.…”
mentioning
confidence: 98%