Gastrointestinal: Refractory dyspepsia due to primary gastric amyloidosis: Sometimes you have to dig deeper

Mieghem, Eugénie Van; Vandamme, Timon; Deman, Frederik; Eyckmans, Tom; Staessen, Dirk

doi:10.1111/jgh.15302

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2022

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“…Primary amyloidosis is associated with multiple myeloma in 15–20% of cases, whereas primary amyloidosis of the GI tract on the other hand is rare with only 1% having had biopsy-proven symptomatic gastric amyloidosis based on a case series of 769 patients with primary systemic amyloidosis [ 6 ]. The highest diagnostic yield from biopsy specimens was found to be the duodenum (50%) followed by stomach (44%), colon (32%), oesophagus (12%) and rectum (8%) [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

A rare case of gastrointestinal amyloidosis secondary to myeloma with predominant jejunal involvement

Anandan¹,

Ying²,

Macisaac³

et al. 2022

Journal of Surgical Case Reports

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Amyloidosis is a condition identified by the accumulation of abnormal proteins in various tissues and organs that eventually lead to impaired function. Systemic amyloidosis with gastrointestinal (GI) tract involvement is more common than localized GI amyloidosis, whereas predominant jejunal involvement is even more uncommon. We report a rare case of systemic amyloidosis with predominant jejunal involvement in a 76-year-old female who presented with lower abdominal bloating and lethargy.

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Section: Discussionmentioning

confidence: 99%