Gastrointestinal–Renal Axis: Role in the Regulation of Blood Pressure

Yang, Jian; José, Pedro A.; Zeng, Chunyu

doi:10.1161/jaha.117.005536

Cited by 29 publications

(28 citation statements)

References 217 publications

(489 reference statements)

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“…Those hormones and humoral factors work via their individual receptors, which have been found to be expressed both inside and outside GI tract, including kidneys ( Dufresne et al, 2006 ; Furness et al, 2013 ). Emerging evidence proves the existence of gastro-renal axis ( Jose et al, 2016a ), GI tract–derived hormones and peptides could regulate the autocrine function of renal hormones, affecting renal function such as sodium excretion ( Michell et al, 2008 ; Yang et al, 2017 ). Numerous GI hormones, like gastrin and cholecystokinin, are secreted during a meal.…”

Section: Introductionmentioning

confidence: 99%

Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling

et al. 2020

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Ischemic/reperfusion (I/R) injury is the primary cause of acute kidney injury (AKI). Gastrin, a gastrointestinal hormone, is involved in the regulation of kidney function of sodium excretion. However, whether gastrin has an effect on kidney I/R injury is unknown. Here we show that cholecystokinin B receptor (CCKBR), the gastrin receptor, was significantly up-regulated in I/R-injured mouse kidneys. While pre-administration of gastrin ameliorated I/R-induced renal pathological damage, as reflected by the levels of serum creatinine and blood urea nitrogen, hematoxylin and eosin staining and periodic acid-Schiff staining. The protective effect could be ascribed to the reduced apoptosis for gastrin reduced tubular cell apoptosis both in vivo and in vitro. In vitro studies also showed gastrin preserved the viability of hypoxia/ reoxygenation (H/R)-treated human kidney 2 (HK-2) cells and reduced the lactate dehydrogenase release, which were blocked by CI-988, a specific CCKBR antagonist. Mechanistically, the PI3K/Akt/Bad pathway participates in the pathological process, because gastrin treatment increased phosphorylation of PI3K, Akt and Bad. While in the presence of wortmannin (1 μM), a PI3K inhibitor, the gastrin-induced phosphorylation of Akt after H/R treatment was blocked. Additionally, wortmannin and Akt inhibitor VIII blocked the protective effect of gastrin on viability of HK-2 cells subjected to H/R treatment. These studies reveals that gastrin attenuates kidney I/R injury via a PI3K/Akt/Bad-mediated anti-apoptosis signaling. Thus, gastrin can be considered as a promising drug candidate to prevent AKI.

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Section: Introductionmentioning

confidence: 99%

Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling

et al. 2020

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“…Gastrointestinal tract–derived hormones and peptides have been shown to regulate autocrine function of renal hormones, including gastrin and glucagon-like-Peptide-1, affecting renal function and mediating sodium excretion [23] . This suggests the existence of a gastrointestinal–renal axis regulating blood pressure [21] .…”

Section: Introductionmentioning

confidence: 95%

“…Not only are the gut and the kidneys both involved in maintaining sodium and fluid balance and thereby blood pressure, there is even evidence suggesting a hormonal communication between the two organs [21] . The gastrointestinal tract screens the food via taste receptors and sensors for electrolytes (eg.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept

Linz

Saljic

Hohl

et al. 2020

IJC Heart & Vasculature

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Arterial hypertension is one of the main contributors to cardiovascular diseases, including stroke, heart failure, and coronary heart disease. Salt plays a major role in the regulation of blood pressure and is one of the most critical factors for hypertension and stroke. At the individual level, effective salt reduction is difficult to achieve and available methods for managing sodium balance are lacking for many patients. As part of the ingested food, salt is absorbed in the gastrointestinal tract by the sodium proton exchanger subtype 3 (NHE3 also known as Slc9a3), influencing extracellular fluid volume and blood pressure. In this review, we discuss the beneficial effects of pharmacological inhibition of NHE3-mediated sodium absorption in the gut and focus on the effect on blood pressure and end-organ damage.

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“…The autonomic nervous system and the endocrine system participate in this regulatory mechanism. The effectiveness of regulating blood pressure depends on the functional dominance of autoregulation and vasoactive hormones over local factors that determine the adaptation of the flow to the current metabolic status of an organ or tissue [40,41].…”

Section: Regulation Of Blood Pre-ssurementioning

confidence: 99%

Gastrointestinal neuroendocrine cells in various types of hypertension – a review

Niezgoda

2017

Prog Health Sci

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Recent years have witnessed a progressive increase in the number of people suffering from hypertension, which is one of the most serious health problems in the world. Hypertension results in changes leading to function disorders, not only of the organs and tissues, but also changes leading to the activation of many defense mechanisms in the cells in order to prevent damage. One of them is the expression of neuroendocrine (NE) hormones and biologically active substances, which has been the focus of extensive research for a number of years. Active involvement of NE cells and the biological and therapeutic properties of various substances synthesized by them have been confirmed in clinical trials and in various experimental models. Results obtained in many research studies indicate intense activity of enteroendocrine cells in the gastrointestinal tract in various pathological conditions, including hypertension. In the present review, we discuss the morphological and functional changes of gastrointestinal neuroendocrine cells under conditions of different types of hypertension.

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Gastrointestinal–Renal Axis: Role in the Regulation of Blood Pressure

Cited by 29 publications

References 217 publications

Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling

Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling

Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept

Gastrointestinal neuroendocrine cells in various types of hypertension – a review

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