Gastrointestinal stromal tumor as cause of hepatic mass

Losada, Héctor; Villaseca, Miguel; Vivallo, Carolina; López, Mario Gonzalo Cantín

doi:10.21037/hbsn.2016.05.04

Cited by 3 publications

(7 citation statements)

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“…A review of the published case reports of primary hepatic stromal tumours over the past 15 years was undertaken (Table 1), which included 13 males and 10females with a median age of 59 years. 2,4,5,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] The common features were that the primary hepatic stromal tumour lacked typical clinical manifestations and patients usually presented as an accidental liver mass. The tumour size ranged from 2.4 to 23 cm with a median size of 15 cm.…”

Section: Discussionmentioning

confidence: 99%

A case of primary hepatic stromal tumour misdiagnosed as a liver cyst

Liu

Sun

et al. 2022

J Int Med Res

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Primary hepatic stromal tumours are very rare and there are only sporadic reports in the literature. Due to the lack of specificity in their clinical manifestations and imaging features, these tumours are easily misdiagnosed. This current report presents a case of primary liver stromal tumour that was misdiagnosed as a liver cyst. The 72-year-old male patient was admitted to the hospital due to right upper abdomen fullness and discomfort for more than 2 weeks. Colour Doppler ultrasonography and enhanced computed tomography examinations revealed a cystic mass in the right lobe of the liver. The preoperative diagnosis was a liver cyst and the laparoscopic fenestration was performed. The pathological examination demonstrated that it was a primary hepatic stromal tumour. Gastroenteroscopy was performed postoperatively and no lesions were found in the gastrointestinal tract. Imatinib mesylate was given orally as the salvage therapy and a radical operation was planned at the patient's request. This current case serves as a reminder that clinicians should consider the possibility that it could be a primary hepatic stromal tumour rather than a hepatic cyst. A multidisciplinary team is necessary for the diagnosis and treatment of patients with a primary hepatic stromal tumour.

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Section: Discussionmentioning

confidence: 99%

A case of primary hepatic stromal tumour misdiagnosed as a liver cyst

Liu

Sun

et al. 2022

J Int Med Res

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“…Five patients [13,22,24,27,31] had a mitotic count of less than 5 mitoses/50 HPF. Similar with the GIST located in GI tract, 27 [9–11,13,14,16–31,33–36,38] out of 28 cases were positive for CD117, the remaining case [32] was positive for CD34, protein kinase C θ, vimentin, and smooth muscle actin (SMA). Furthermore, other proteins such as CD34 (57.1% patients), vimentin (35.7% patients), DOG-1 (21.4% patients), and SMA (17.6% patients) were also could be identified in some primary hepatic EGISTs.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Geographically, most cases were reported in Asia; (China [21, 70.0%], [9,11–30] Japan [3, 10%], [10,31,32] Korea [1, 3.3%]), [33] and other cases were sporadically reported in India (2, 6.67%), [34,35] Italy (2, 6.67%), [36,37] and Chile (1, 3.3%). [38] Among them, 28 [9–11,13,14,16–36,38] out of 30 studies provided the basic clinicopathological information and survival outcomes of the patients as shown in the Table 1.…”

Section: Literature Reviewmentioning

confidence: 99%

“…The tumor size ranged from 2.4 to 44 cm with a median size of 15 cm. Among them, 71.4% (20/28) patients [9,11,13,14,17,18,20,21,23,26,27,29–32,34–36,38] had a tumor size of more than 10 cm. Two cases [17,34] presented with multinodular tumors and 1 case [35] had 1 main tumor with 2 small satellite nodules.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Regarding their treatment, 21 patients [10,11,13–17,19–21,23,25,27,30–36,38] underwent curative hepatectomy, 1 patient [22] underwent laparotomy radiofrequency ablation (RFA) due to a tumor size of 5.1 cm, 1 patient [24] adopted microwave ablation (MWA) for a tumor size of 2.4 cm and 1 patient [29] with multiple huge cystic masses (the smallest 1 was more than 20 cm) underwent repeated drainage, other 4 patients [9,18,26,28] were not treated surgically. For adjuvant therapy, imatinib which is also known as Gleevec, was prescribed for 10 patients [9,11,14,21,24,25,32,34–36] including 1 patient [9] who did not undergo surgery.…”

Section: Literature Reviewmentioning

confidence: 99%

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Primary hepatic gastrointestinal stromal tumor with right adrenal gland invasion

Zhang

2019

Medicine

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Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors that mainly occur in the gastrointestinal tract. The GISTs that are sporadically reported in extra-gastrointestinal regions are named as extra-gastrointestinal stromal tumors (EGISTs). However, the primary EGISTs that originate from the liver are rare. Patient Concerns: A 64-year-old female presenting with right upper abdominal pain and thirsty for more than 20 days. Diagnosis: A diagnosis of a 15 × 14 × 7 cm liver mass located in the posterior right lobe of liver and spread to the right adrenal gland was confirmed. Pathological results showed that the tumor was mainly composed of epithelial cells and tested positive for CD117 and SDHB (succinate dehydrogenase complex iron sulfur subunit B). The gene mutational analyses for c-Kit and platelet-derived growth factor receptor alpha exons revealed negative results. Fluorescence in situ hybridization of murine double minute 2 produced negative fluorescence results which distinguished it from dedifferentiated liposarcomas. The postoperative gastroduodenal and colorectal endoscopy did not find any neoplastic lesions. To this end, the diagnosis of primary hepatic EGIST of wild type nature was confirmed. Interventions: The patient received right hepatectomy and adrenalectomy, no postoperative chemotherapy was administered. Outcomes: The patient died 11 months after surgery due to tumor metastasis. Conclusion: Primary hepatic EGIST is a rare and complicated disease of liver, a multidisciplinary team is necessary in diagnosis and treatment of primary hepatic EGIST.

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Prevalence, diagnosis, and treatment of primary hepatic gastrointestinal stromal tumors

Qian¹,

Yan²,

Gao³

et al. 2020

WJG

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Gastrointestinal stromal tumors (GIST), which is the most common mesenchymal tumor of the digestive tract, account for 1%-3% of gastrointestinal tumors. Primary stromal tumors outside the gastrointestinal tract are collectively referred to as extra GISTs, and stromal tumors in different regions often have different prognoses. A primary hepatic GIST is a rare tumor with an unknown origin, which may be related to interstitial Cajal-like cells. Although primary hepatic GIST has certain characteristics on imaging, it lacks specific symptoms and signs; thus, the final diagnosis depends on pathological and genetic evidence. This review summarizes all cases of primary hepatic GIST described in the literature and comprehensively analyzes the detailed clinical data of all patients. In terms of treatment, local resection alone or with adjuvant therapy was the prioritized choice to obtain better disease-free survival and longer survival time. For advanced unresectable cases, imatinib mesylate was applied as the first-line chemotherapy agent. Moreover, transcatheter arterial chemoembolization, radiofrequency ablation, and microwave ablation were shown to improve overall survival for selected patients. Liver transplantation was a final treatment option after resistance to chemotherapy developed.

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Gastrointestinal stromal tumor as cause of hepatic mass

Cited by 3 publications

References 0 publications

A case of primary hepatic stromal tumour misdiagnosed as a liver cyst

A case of primary hepatic stromal tumour misdiagnosed as a liver cyst

Primary hepatic gastrointestinal stromal tumor with right adrenal gland invasion

Prevalence, diagnosis, and treatment of primary hepatic gastrointestinal stromal tumors

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