Gastrointestinal stromal tumor in the duodenum exhibiting hemangiopericytoma‐like histological pattern

Takahashi, Yoshihisa; Shimizu, Satoshi; Sakurai, Shunsuke; Kumagai, Arisa; Mori, Shigeki; Fukusato, Toshio

doi:10.1111/j.1440-1827.2008.02335.x

Cited by 6 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Takahashi et al described a case of gastro-intestinal stromal tumor (GIST) with hemangiopericytoma-like histological features. This case suggested that additional immunohistochemical and mutations analysis of the KIT gene should be performed in case of primary brain lesion with distant gastro-intestinal tract lesions; in order to distinguish between meningioma gastro-intestinal tract (GIT) metastases, hemangiopericytoma GIT metastases, and GIST with hemangiopericytoma-like histological pattern [17].…”

Section: Discussionmentioning

confidence: 99%

Grade III meningioma with gastro-intestinal tract and brain metastases: case report and review of the literature

Bender

Lhermitte

Carinato³

et al. 2019

World J Surg Onc

View full text Add to dashboard Cite

Background Meningioma is the most common adult primary intracranial tumor. Malignant meningioma is a rare variant of meningioma. The prognosis for the patients with these tumors is poor, due to the tumor’s capacity for relapse and to develop distant metastases. These tumors can present the same evolutionary course as aggressive carcinoma. Case description We report the case of distant brain and gastro-intestinal tract (GIT) metastases. A 78-year-old patient developed malignant meningioma with a Ki-67 proliferative index of 40%. According to guidelines, surgery followed by postoperative radiotherapy (RT) was performed. Three months after the end of RT, he presented histologically proven meningioma distant brain and GIT metastases. Conclusions To our knowledge, this is the first case of meningioma GIT metastases. Also, we report the difficulty to confirm the diagnosis of meningioma metastases. Indeed, malignant meningioma has the same histopathological features as melanoma or carcinoma. The standard of care for the management of malignant meningioma is gross total surgery followed by postoperative radiotherapy. Metastatic meningioma is uncommon and no guidelines for the management of recurrent or metastatic meningioma have yet been published. However, several studies reported systemic therapeutic options such as antibody against VEGF, somatostatin analogs, PDGF-R, and VEGF-R tyrosine kinase inhibitors, in the case of recurrent or metastatic meningioma. We also made a review of the actual literature of systemic treatment options for metastatic meningioma.

show abstract

Section: Discussionmentioning

confidence: 99%

Grade III meningioma with gastro-intestinal tract and brain metastases: case report and review of the literature

Bender

Lhermitte

Carinato³

et al. 2019

World J Surg Onc

View full text Add to dashboard Cite

show abstract

“…In addition, a hemangiopericytomatous vasculature and biphasic pattern can be observed in case of GISTs [17,18]. In such cases, the use of immunohistochemistry to detect the c-kit receptor tyrosine kinase (CD117) would be helpful in diagnosis, because CD117 expression has apparently never been described for myofibromas.…”

Section: Discussionmentioning

confidence: 99%

Solitary myofibroma of the sigmoid colon: case report and review of the literature

et al. 2013

View full text Add to dashboard Cite

A 58-year-old woman presented with a solitary myofibroma that arose in the sigmoid colon. Computed tomography revealed a highly enhanced intramural mass (1.3-cm maximum diameter) in the proximal sigmoid colon. Histologically, the tumor exhibited a biphasic growth pattern, which comprised haphazardly arranged, interwoven fascicles of plump, myoid-appearing spindle cells with elongated nuclei and abundant eosinophilic cytoplasm, and more cellular areas of primitive-appearing polygonal cells that were arranged in a hemangiopericytomatous pattern. The tumor cells were positive for smooth muscle actin (SMA), and negative for desmin, h-caldesmon, CD34, cytokeratin, S100 protein, and CD117. The Ki-67 labeling index was not high (up to 7%). Based on these histologic and immunohistochemical features, our patient was diagnosed with a myofibroma of the sigmoid colon. The presence of solitary myofibroma in the intestine of an adult requires attention to avoid misdiagnosis as a more aggressive mesenchymal tumor.Virtual SlidesThe virtual silde(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2096403796957687

show abstract

Clinicopathological features, surgical strategy and prognosis of duodenal gastrointestinal stromal tumors: a series of 300 patients

et al. 2018

View full text Add to dashboard Cite

BackgroundThe relatively low incidence of duodenal gastrointestinal stromal tumors (GISTs) and the unique anatomy make the surgical management and outcomes of this kind of tumor still under debate. Thus, this study aimed to explore the optimal surgical strategy and prognosis of duodenal GISTs.MethodsA total of 300 cases of duodenal GISTs were obtained from our center (37 cases) and from case reports or series (263 cases) extracted from MEDLINE. Clinicopathological features, type of resections and survivals of duodenal GISTs were analyzed.ResultsThe most common location of duodenal GISTs was descending portion (137/266, 51.5%). The median tumor size was 4 cm (0.1–28). Most patients (66.3%) received limited resection (LR). Pancreaticoduodenectomy (PD) was mainly performed for GISTs with larger tumor size or arose from descending portion (both P < 0.05). For both the entire cohort and tumors located in the descending portion, PD was not an independent risk factor for disease-free survival (DFS) and disease-specific survival (DSS) (both P > 0.05). Duodenal GISTs were significantly different from gastric GISTs with respect to tumor size, mitotic index and NIH risk category (all P < 0.05). The DFS and DSS of duodenal GISTs was significantly worse than that of gastric GISTs (both P < 0.05).ConclusionsLR was a more prevalent surgical procedure and PD was mainly performed for tumors with larger diameter or located in descending portion. Type of resection was not an independent risk factor for the prognosis of duodenal GISTs. Prognosis of duodenal GISTs was significantly worse than that of gastric GISTs.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-4485-4) contains supplementary material, which is available to authorized users.

show abstract

Gastrointestinal stromal tumor in the duodenum exhibiting hemangiopericytoma‐like histological pattern

Cited by 6 publications

References 11 publications

Grade III meningioma with gastro-intestinal tract and brain metastases: case report and review of the literature

Grade III meningioma with gastro-intestinal tract and brain metastases: case report and review of the literature

Solitary myofibroma of the sigmoid colon: case report and review of the literature

Clinicopathological features, surgical strategy and prognosis of duodenal gastrointestinal stromal tumors: a series of 300 patients

Contact Info

Product

Resources

About