Gastrointestinal Stromal Tumor Mimicking as Ovarian Tumor in Gynaecologic Oncology

Abstract

To report the clinical presentation and outcomes of a series of patients who presented with abdominal/pelvic mass or pelvic pain and were diagnosed with a gastrointestinal stromal tumor (GIST). Retrospective data were collected of all patients who presented with an abdominal/pelvic mass or pelvic pain between January 2010 and July 2015 and who were ultimately diagnosed with a GIST. The patients' medical records were reviewed. A literature review was also conducted. The event free survival and overall survival was calculated for all patients using Kaplan Meier curve (SPSS19-SPSS Inc. USA). A total ten patients were identified with GIST during the study period. Eight of ten patients had a tumor in the small intestine, one in sigmoid colon and one in base of small bowel mesentry. The mean tumor size was 13.9 cm (range, 3.9 to 24 cm). A complete resection was achieved in all 10 patients. No patient had distance metastasis. There were no intraoperative complications. One patient developed postoperative intestinal fistula and was managed conservatively. All patients were treated with imatinib after surgery. The mean follow-up time was 18 months (range, 2 to 47 months). The seven of the 10 patients (70 %) with no evidence of disease, two (20 %) lost follow up and one patient developed recurrence during follow up period and was started on sunitinib and patient died during follow up period because of disease. Gastrointestinal stromal tumors should be considered in the differential diagnosis of patients presenting with an abdominal/pelvic mass or pelvic pain in Gynaecologic oncology department. In such unusual circumstances the complete resection and appropriate adjuvant treatment results in complete durable remission.

Gastrointestinal stromal tumor metastasis to the ovary: A case report

“…Furthermore, in the gynecological region, when large ovarian tumors are in contact with the uterus or bladder, it is difficult to distinguish them from uterine bladder tumors in images. 22 In the current case, the pelvic tumor was large, and it was difficult to identify the ovary. Imatinib treatment significantly reduced the tumor, and the ovaries could be identified and were found to be in contact with the ovaries.…”

Jejunal GIST masquerading as an ovarian mass: A case report

“…MRI was done in our case because of a suspected malignant ovarian mass in the USG abdomen. It is difficult to distinguish GIST of the small bowel and rectosigmoid areas from ovarian tumors based on clinical features and imaging studies [ 10 ]. Moreover, leiomyoma and leiomyosarcoma of the small intestine can mimic primary ovarian neoplasm [ 11 ].…”

Gastrointestinal Stromal Tumors Mimicking Gynecologic Disease: Clinicopathological Analysis of 20 Cases

“…Some tumors contained hyalinized collagens (E, case 11). In some cases, viable cells are present only around the blood vessel and ghostlike outlines of necrotic atypical tumor cells can still be discerned in the surrounding tissue (F, case 16). Original magnification: (A), ×20; (B-F), ×200.…”

“…In many patients, GISTs are often an incidental finding during operation and/or detected through screening examinations with unspecific symptoms. When presented as a pelvic mass, diagnosis of a GIST could be challenging due to its nonspecific presentation and similarity in appearance to gynecological neoplasms [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. On rare occasions, these tumors can present as a rectovaginal mass for which the differential diagnosis is broad [ 24 , 25 ].…”