Gastrointestinal stromal tumor of the lesser omentum: a case report and review of the literature

Ninomiya, Shigeo; Hiroishi, Kazuaki; Shiromizu, Akio; Ueda, Y.; Shiraishi, Norio; Ito, Masafumi; Arita, Tsuyoshi

doi:10.1093/jscr/rjz035

Cited by 8 publications

(7 citation statements)

References 11 publications

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“…The suspicion of EGIST was present on imaging of 2 cases from our series but the con rmation of its presence, in all the cases, was only possible after surgical pathology completion. Thorough radiological assessment is pivotal in the diagnosis of abdominal neoplasms, but it may still be di cult to differentiate a neoplastic occurrence in the lesser omentum from an occurrence in the gastric lesser curvature thus delaying the nal diagnosis until surgery (11). In addition, few papers have reported instances where a radiologically suspected ovarian tumor turned out to be an EGIST "in-disguise" (12).…”

Section: Discussionmentioning

confidence: 99%

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Extra-Gastrointestinal Stromal Tumors (EGISTs): A Case Report for A Mischief Entity

Sbaity

Charif

Amro

et al. 2022

Preprint

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Background: Extra-gastrointestinal stromal tumor (EGIST) is a rare subtype of soft tissue sarcomas with significantly variable presentation, management and prognosis. This makes it crucial to report the different institutional experiences of encountering EGIST.Case Presentation: We report three cases of EGIST diagnosis at our institution for 2 males and 1 female in the 5th, 6th and 7th decades of life, respectively. For the first case, the tumor was initially suspected to be ovarian cancer but biopsy revealed a diagnosis of EGIST and the patient was started on neoadjuvant therapy. In the second case, the tumor was retrogastric and prelim diagnosis was gastric cancer but again biopsy revealed an EGIST histopathology and the patient underwent surgery and adjuvant treatment. For the third case, a previous history of testicular cancer prompted an initial suspicion of recurrence with metastasis but biopsy and immunohistochemistry staining revealed EGIST with related markers. The patient underwent treatment at a different institution in his home country.Conclusion: This report sheds light on the importance of keeping EGIST amongst any differential list for abdominal and pelvic tumors. It also shows that EGIST-focused studies are needed to assess the effectiveness of the different treatment modalities available when utilized specifically for EGIST. This would allow for better oncological outcomes and improved quality of life.

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Section: Discussionmentioning

confidence: 99%

“…Treatment of EGISTs that are diagnosed early is radical resection of the tumor, which is the only known curative treatment. for, On the other hand, targeted therapy with molecules such as imatinib or sunitinib is reserved for advanced cases and proves most effective in those with C-kit positive mutations (3,11,14).…”

Section: Discussionmentioning

confidence: 99%

Extra-Gastrointestinal Stromal Tumors (EGISTs): A Case Report for A Mischief Entity

Sbaity

Charif

Amro

et al. 2022

Preprint

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“…Primary tumors of the lesser omentum are rare. Most are benign tumors such as lymphangiomas and hemangiomas, with isolated reports of gastrointestinal stroma tumors and malignancies such as soft tissue sarcoma, lymphoma, and small cell carcinoma[ 37 - 40 ]. There are 5 reports of primary gastrinoma of the lesser omentum (Table 2 )[ 41 - 44 ].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of gastric gastrinoma after resection of metastases to the lesser omentum: A case report and review of literature

Okamoto¹,

Yoshimoto²,

Ohike³

et al. 2021

WJG

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“…If a gastric stromal tumor is a growth in the extra-gastric cavity located close to other organs in the abdominal cavity or if it even compresses the adjacent organs and there are no clinical symptoms, it is easy to misdiagnose as the abdominal cavity or as another organ occupying lesions. According to the best of authors knowledge there were only several published cases reports describes the pedunculated GISTs mimicked hepatic tumor and pancreatic tumor [13][14][15] . Sometimes, the extra gastrointestinal GIST involving lesser omentum, it is also difficult to differentiate the origin, and may be misdiagnosed as hepatic hemangioma and extramucosal tumor of the stomach.…”

Section: Discussionmentioning

confidence: 99%

Characteristic of extra luminal gastric stromal tumor arising from the lesser curvature of the stomach

Wang¹,

Qiu

et al. 2020

Medicine

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Rationale: Gastrointestinal stromal tumor (GIST) is one of the most common malignant mesenchymal tumors of the gastrointestinal tract. They generally arise from the fourth layer (muscularis propria) and rarely from the second or third layer. Although the manifestations of gastric stromal tumors are diverse, to our knowledge, there are only several cases of an extra-gastric stromal tumor in the literature appearing with a pedunculation. Pedunculated large GISTs are not frequent and compress the neighboring organs. When they were huge, it is difficult to differentiate the origin of the masses. Thus, in the clinical setting, physicians should pay more attention to the pattern of manifestation of the gastric stromal tumor.Patient concerns: A 62-year-old man had no gastrointestinal symptoms or significant medical and family histories. During the health examination with US, a cystic-solid tumor was found below liver. The results of the physical examination were unremarkable, and routine laboratory data on admission did not show any abnormal findings.Diagnosis: Computed tomography of the abdomen showed a mixed echoic mass measuring 10 Â 8 Â 8 cm and located below the liver, adjacent to the gastric antrum. After endoscopic ultrasound-guided fine-needle aspiration, cytopathology showed that the specimen was filled with red blood cells, and it had no malignant cells. Histopathology revealed that the mass was a GIST, and immunohistochemical analysis showed the following: CD117(+), CD34(+), desmin(À), Dog-1(+), Ki-67% <1%, and smooth muscle actin(À).Interventions: Surgical resection was performed on the patient.Outcomes: The lesion was diagnosed as a gastric stromal tumor with a pedicle and an old hemorrhage. The patient's recovery was uneventful. After surgery, computed tomography at the 6-month and 1-year postoperative follow-up visits did not reveal relapse or any metastasis.Lessons: In the clinical setting, physicians should pay more attention to the pattern of manifestation of the extra-gastric stromal tumor in patients with a pedicle or hemorrhage. Additionally, endoscopic ultrasound-guided fine-needle aspiration can be used to make an accurate preoperative diagnosis of such diseases, and its findings can serve as an important basis for surgical excision of the lesions.

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Gastrointestinal stromal tumor of the lesser omentum: a case report and review of the literature

Cited by 8 publications

References 11 publications

Extra-Gastrointestinal Stromal Tumors (EGISTs): A Case Report for A Mischief Entity

Extra-Gastrointestinal Stromal Tumors (EGISTs): A Case Report for A Mischief Entity

Spontaneous regression of gastric gastrinoma after resection of metastases to the lesser omentum: A case report and review of literature

Characteristic of extra luminal gastric stromal tumor arising from the lesser curvature of the stomach

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