Gastrointestinal stromal tumors

Alghamdi, Hanan M.; Amr, Samir S.; Shawarby, Mohamed A.; Sheikh, Salwa S.; Alsayyah, Ahmed; Alamri, Ali; Ismail, Mona H; Almarhabi, Ahmed; Alrefaee, Munir; Ahmed, Muhammad Iftikhar

doi:10.15537/smj.2019.2.23913

Cited by 12 publications

(9 citation statements)

References 19 publications

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“…Patients in our study most frequently presented with abdominal pain (78.7%). This finding is consistent with Al-Thani et al, in which abdominal pain was pres-ent in most of the patients (85%) (20), and Alghamdi et al, (16). In most reports, gastrointestinal bleeding was the most frequent clinical manifestation as reported by Miettinen et al, (21), Aghdassi et al, (12), and Zhao et al, (7).…”

Section: Discussionsupporting

confidence: 89%

“…In our study, the mean PFS was 20.75 months ranging between 7months and 39 months. The PFS was better in patients with gastric site primary which is similar to the results of Di Vita et al, (23), and Alghamdi et al, (16). Lillemoe et al, in a study of 133 patients with resected GIST also reported that survival was related to the tumor's site (26).…”

Section: Discussionsupporting

confidence: 84%

“…More than half of GIST cases in the Egyptian study reported by Sorour et al originated from the stomach (15). According to Alghamdi et al, The most frequently affected organs were the stomach (63.8%) (16). According to Bokhary et al, 51.4 % of GIST cases in the Saudi Arabian study originated from the stomach (17).…”

Section: Discussionmentioning

confidence: 99%

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The tumor site of origin and its effect on survival in gastrointestinal stromal tumors(GIST)

Omar

Ali

Abdelatif

2021

Sohag Medical Journal

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 84%

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The tumor site of origin and its effect on survival in gastrointestinal stromal tumors(GIST)

Omar

Ali

Abdelatif

2021

Sohag Medical Journal

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“…Small intestine GISTs express more often S100 and SMA. SMA is also a negative prognostic factor in localized tumors (there is a direct correlation between its positivity and disease relapse) ( 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

A multidisciplinary approach in the diagnostic challenge of GIST

et al. 2021

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Gastrointestinal stromal tumors (GISTs) are the most common malignant mesenchymal lesions of the gastrointestinal tract. They originate from the interstitial cells of Cajal and are characterized by overexpression of the tyrosine kinase receptor, protein product of c-KIT gene (KIT). In this retrospective study, conducted over a period of 10 years, we retrieved from our database, a total number of 57 patients, admitted and operated in the surgical department of 'Sf. Pantelimon' Emergency Clinical Hospital, Bucharest, for digestive tumors, histopathologically confirmed as GISTs. More than half of the cases presented as surgical emergencies and the tumors found during the surgical procedures, which proved to be GISTs, were sometimes difficult to differentiate from other mesenchymal tumors, both for the clinician and the pathologist. The diagnosis of GIST relies mostly on pathology and immunohistochemistry, but also on clinical and imagistic data. The most common emergencies were digestive hemorrhage (associated with gastric location), followed by intestinal obstruction (especially for the ileal localization). The largest dimensions corresponded to gastric location. For selected indications (upper digestive sites), upper digestive endoscopy approaches 100% sensitivity. This study focuses on diagnosis of GISTs sustained by both clinical and imagistic methods, along with histopathology and immunohistochemistry techniques, according to the World Health Organization 2019 criteria. Even though the differential diagnosis of these tumors is challenging, an interdisciplinary cooperation with a multiple approach increases the odds of a correct positive diagnosis.

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“…Symptomatic MD such as gastrointestinal bleeding, Meckel diverticulitis, perforation, and bowel obstruction can all be treated by resection of symptomatic MD. GIST accounts for less than 1% of all gastrointestinal malignancies, their most common location being the stomach [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumor in ruptured Meckel's diverticulum located in jejunum caused myelosuppression for a short time: A case report

Jia

2021

International Journal of Surgery Case Reports

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Introduction and importance Gastrointestinal stromal tumor (GIST) in Meckel's diverticulum (MD) is rare but it seems to be a common phenomenon that GIST triggers MD perforation or rupture; the exact mechanism is unclear. In addition, the location of GIST in perforated or ruptrued MD is most common in ileum, rarely in jejunum. We herein report a GIST in ruptured MD Located in jejunum and severe peritoneal cavity infection leads to myelosuppression. Case presentation A female patient was admitted to our hospital with “abdominal pain”. Physical examination and laboratory tests revealed that the patient was in shock and myelosuppression. Abdominal X-ray photograph and computed tomography indicated perforation of digestive tract. Laparotomy revealed rupture of MD located 90 cm from the Treitz ligament and a tumor was also found in the MD. As the condition is critical, the MD was excisioned from its root and the small bowel gap was closed and repaired. Laboratory indicators showed that myelosuppression was removed 24 h after operation. The pathological findings established a GIST in the MD. The patient was discharged on postoperative day 5 without significant complications. Clinical discussion A GIST in ruptured MD Located in jejunum caused the severe peritoneal cavity infection and myelosuppression In a short time, as seen in this case. Failure to recognize the severity of the disease and delay in treatment will endanger the life of the patient. Conclusion GIST in MD Located in jejunum is very rare, and the rupture of the MD can be life-threatening at any time.

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Gastrointestinal stromal tumors

Cited by 12 publications

References 19 publications

The tumor site of origin and its effect on survival in gastrointestinal stromal tumors(GIST)

The tumor site of origin and its effect on survival in gastrointestinal stromal tumors(GIST)

A multidisciplinary approach in the diagnostic challenge of GIST

Gastrointestinal stromal tumor in ruptured Meckel's diverticulum located in jejunum caused myelosuppression for a short time: A case report

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