Gastrointestinal stromal tumors: A clinical and histopathological presentation of 27 cases

Abstract

We analyzed the clinical and pathological characteristics of GIST. The most common site of tumor origin was the stomach. The size, mitotic index, and Ki-67 values were to be found high in intermediate- and high-risk groups and metastatic diseases.

Immunohistochemical diagnosis of gastrointestinal stromal tumor (GIST) and nurse knowledge / Diagnóstico imuno-histoquímico do tumor estromal gastrointestinal (GIST) e conhecimento da enfermeira

“…Large volume tumors are composed of spindle cells, and they are more common in the stomach and so respond better to treatment compared to those composed of epithelioid cells. When relating the results of survival and morphology, it was possible to observe a confirmation of what was found in the literature, since of the patients who maintained their follow-up at the service, 85.7% had fusiform cells (the most found) and, as seen previously, has a better response to treatment 8,23 .…”

“…In the present survey, we found a percentage of approximately 52% of tumors in the stomach and only one case in the rectum and esophagus. Acoording to the literature, in 50 -60% of the cases, the most common site is the stomach, and are rarely found in extra-intestinal regions 7,8 .…”

“…Gastrointestinal Stromal Tumor (GIST) is a neoplasm that affects cells of gastrointestinal tract (GI) called interstitial cells of Cajal (ICCs) 8 . These cells are known as "pacemakers" of the gastrointestinal tract with mesenchymal origin and make the connection between smooth muscle and innervation of the intestinal wall.…”

“…GIST is rare and corresponds to 0.1-3% of all neoplasms of the gastrointestinal tract, however it is the most common mesenchymal neoplasm of this system 1 . It mainly affects the stomach, ranging from 50% to 60% of cases, followed by the small intestine, colon, rectum and esophagus 8 . It can also develop in places outside the gastrointestinal tract, as rarely in the peritoneum and mesentery.…”

“…GIST can be classified into three histological subtypes: fusiform (70%), epithelioid (10%) and mixed (20%). Currently, parameters such as mitotic index, tumor size, mucosal invasion, and presence of tumor necrosis are used, whose objective is to determine the prognosis 8 .…”