Gastrointestinal stromal tumors (GIST): a retrospective study of 10 cases in Senegal

Fall, Fatou; Ndiaye, B.; Ndiaye, A.; Guèye, N.N.; Gning, S. B.; Niang, A.; Soko, T.O.; Diallo, I.; Ogougbemy, M.; Diouf, M.; Mbaye, P. S.

doi:10.1007/s12157-011-0290-2

Cited by 7 publications

(19 citation statements)

References 19 publications

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“…The median age at diagnosis was 52 years. Similar data are reported by other series from Africa [6,7]. The median age in western series seems higher than our, ranging from 65,8 to 69 years [12,13,14].…”

Section: Discussionsupporting

confidence: 92%

“…Similar trends were seen in other African series. Only 19 cases of gastric GIST were identi ed in Cairo, Egypt over a 6 year period at the National Cancer Institute; and 10 cases of GIST (all localizations included) over a 8 year period at the main hospital of Dakar, Senegal [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…Although the potentially curative treatment for GISTs is surgical resection, their management has been revolutionized by the approval of imatinib as an adjuvant and neoadjuvant therapy [3,4,5]. Few studies have been made on GIST in Africa and to the best of our knowledge, no case series has been published in Benin [6,7]. Tumors are often diagnosed at later stage in Africa [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Tumors are often diagnosed at later stage in Africa [8,9]. Access to treatment was di cult in Africa especially in Benin because of the cost of imatinib [7,10]. The availability of imatinib in Benin, thanks to the Glivec International Patient Assistance Program (GIPAP), over the past 5 years has revolutionized the management of this disease [11].…”

Section: Introductionmentioning

confidence: 99%

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Challenge of Gastro-Intestinal Stromal Tumor Management in Low-Income Countries : Example of Benin

Gbéssi

Gnangnon

Kpossou

et al. 2021

Preprint

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Background: GISTs are rare tumors but the most frequent mesenchymal tumors of the digestive tract. Diagnosis and treatment are challenging in low-income countries due to relatively poor access to immunohistochemistry and targeted therapy. In Africa there are few studies about it. This study described the diagnosis and therapeutic management of GIST in Cotonou, Benin.Methods: This was a descriptive cross-sectional study, with retrospective data collection over a 10-year period from 2010 to 2020, focused on patients with histological confirmed gastro-intestinal stromal tumor (GIST). Data analysis was performed with Epidata Analysis software version 3.0.0.1.Results: Fifteen GISTs were identified during the study period. The median age was 52 and the sex ratio was 2. The most frequent symptom was abdominal pain (n = 12). Delay in care seeking after onset of symptoms ranged from 24 hours to 15 years. The most common site for GISTs was the stomach (n = 8). The median tumor size was 11 cm and the majority (n=10) was metastatic or locally advanced at the time of diagnosis. The tumors were often spindle-shaped at histology (n = 13) and the majority expressed KIT (n = 14). Most of the tumors (n = 12) were at high risk of recurrence according to the Joensuu scoring system. The availability of imatinib have improved the outcome of GIST with response in all cases it was used in neoadjuvant setting (n = 7).Conclusion: GISTs are rare tumors and preferentially affect the stomach in Cotonou. Most of the tumors were large, unresectable at the time of diagnosis and at high risk of recurrence. Access to imatinib has revolutionized the management of those tumors in our country.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Challenge of Gastro-Intestinal Stromal Tumor Management in Low-Income Countries : Example of Benin

Gbéssi

Gnangnon

Kpossou

et al. 2021

Preprint

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“…43,5 % des GIST étaient diagnostiquées au stade métastatique chez nos patients. Ce diagnostic tardif, observé également dans d'autres études africaines [19][20][21], est lié surtout à la difficulté d'accès aux structures sanitaires de référence. Il existe une grande diversité histologique des GIST.…”

Section: Discussionunclassified

Les tumeurs stromales gastro-intestinales : expérience de vie réelle d’un centre marocain

Bazine¹,

Fetohi²,

Namad³

et al. 2018

Hegel

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Présentations cliniques et pronostiques des tumeurs stromales gastro-intestinales (GIST) dans un service d’oncologie médicale d’Afrique subsaharienne, à l’ère des thérapies ciblées

Diallo

Dembélé

Auberger³

et al. 2017

J Afr Hepato Gastroenterol

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Gastrointestinal stromal tumors (GIST): a retrospective study of 10 cases in Senegal

Cited by 7 publications

References 19 publications

Challenge of Gastro-Intestinal Stromal Tumor Management in Low-Income Countries : Example of Benin

Challenge of Gastro-Intestinal Stromal Tumor Management in Low-Income Countries : Example of Benin

Les tumeurs stromales gastro-intestinales : expérience de vie réelle d’un centre marocain

Présentations cliniques et pronostiques des tumeurs stromales gastro-intestinales (GIST) dans un service d’oncologie médicale d’Afrique subsaharienne, à l’ère des thérapies ciblées

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