Gastrointestinal Stromal Tumors of the Stomach with Extensive Calcification: Report of Two Cases

Kim, Hyun Soo; Sung, Ji Youn; Park, Won Seo; Kim, Youn Wha

doi:10.2169/internalmedicine.51.8182

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…The clinical similarities between these two entities as well as the similarities found on CT scan explain the possible confusion between the two diagnoses. There are several published cases of GIST mimicking SPEN 28 , 33 as well as SPEN mimicking GIST. 34 , 35 …”

Section: Discussionmentioning

confidence: 99%

Solid pseudopapillary tumor of the pancreas mistaken for gastrointestinal stromal tumor: A case report

Achemlal,

Essaoudi,

Jidal

et al. 2024

SAGE Open Medical Case Reports

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Solid pseudopapillary epithelial neoplasms of the pancreas are rare entities, first described in 1959 by Frantz. These tumors represent less than 2% of pancreatic cancers and mainly affect young women. They can reach a significant size and its radiological features can lead to diagnostic pitfalls, such as gastrointestinal stromal tumors, which are rare soft-tissue sarcomas that can appear anywhere along the gastrointestinal tract. Clinicians and radiologists need to be aware of the existing diagnostic pitfalls between these two entities, because of their possible similarities. We report here the case of a 33-year-old woman with a solid pseudopapillary epithelial neoplasms of the pancreas initially misdiagnosed as an exophytic gastric stromal tumor.

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Section: Discussionmentioning

confidence: 99%

Solid pseudopapillary tumor of the pancreas mistaken for gastrointestinal stromal tumor: A case report

Achemlal,

Essaoudi,

Jidal

et al. 2024

SAGE Open Medical Case Reports

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show abstract

“…Contrariwise, coarse and extensive calcifications represent an uncommon radiological finding, and only a few cases of these have been reported in the literature[17-23]. Indeed, our search of the MEDLINE/PubMed database identified only 8 cases of extensively calcified GISTs (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Heavily calcified gastrointestinal stromal tumors: Pathophysiology and implications of a rare clinicopathologic entity

Salati¹,

Orsi²,

Bonetti³

et al. 2017

WJGO

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and are characterized by a broad spectrum of clinical, histological and molecular features at presentation. Although focal and scattered calcifications are not uncommon within the primary tumor mass, heavy calcification within a GIST is rarely described in the literature and the clinical-biological meaning of this feature remains unclear. Cases with such an atypical presentation are challenging and may be associated with diagnostic pitfalls. Herein, we report a gastric GIST with the unusual presentation of prominent calcifications that was identified incidentally on imaging during a post-trauma diagnostic work-up. The patient underwent laparoscopic surgery with a radical resection of the mass, which was subsequently characterized by histological analysis as spindle-shaped tumor cells, positive for CD117/c-KIT, CD34 and DOG1, and with calcified areas. Given the intermediate risk of recurrence, no adjuvant therapy was recommended and the patient underwent regular follow-up for 22 mo, with no evidence of relapse. Our case can be considered of interest because of the rarity of clinical presentation and the uniquely large size of the GIST at diagnosis (longest diameter exceeding 9 cm). In closing, we discuss the pathophysiology and clinical implications of calcifications in GISTs by reviewing the most up-to-date relevant literature.

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“… 6 Hypo- or paucicellularity, stromal fibrosis, hyalinization, myxoid changes, rhabdomyoblastic differentiation and or calcification are likely to be seen in treated GIST. Although some cases were reported in GISTs with extensive calcification prior to therapy, 2 , 7 only one case has been reported in the literature that shows osseous differentiation. 3 The exact mechanism of calcification and chondro-osseous or osseous differentiation is not clearly understood.…”

Section: Discussionmentioning

confidence: 99%

Gastric gastrointestinal stromal tumor with osseous differentiation and stromal calcification: A case report and review of literature

Al-Maghrabi

Meliti

2017

SAGE Open Medical Case Reports

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Gastrointestinal stromal tumors are the most common primary mesenchymal tumors of the gastrointestinal tract accounting for 0.1%–3.0% of all gastrointestinal malignancies. The stomach is the most common site (60%) followed by the small bowel (30%–35%) particularly jejunum and ileum, colorectum (5%) and rarely affect esophagus and appendix. Most gastrointestinal stromal tumors arise sporadically, however, less commonly they develop in association with various clinical syndromes like Carney triad, Carney–Stratakis syndrome, familial gastrointestinal stromal tumor syndrome and neurofibromatosis type1 (NF1). We report a 65-year-old male patient presented with gastric mass (7.5 × 4.5 × 3.5 cm) arising from the posterior gastric wall. Histologic examination revealed neoplastic proliferation of spindled and epithelioid cells with focal plexiform pattern and low mitotic activity 3/50 HPF. No evidence of cytological atypia, abnormal mitosis or necrosis. Interestingly enough, there were focal areas of mature bone formation/osseous differentiation associated with calcification. The tumor cells were strongly positive for CD117, DOG1 with focal immunoreactivity against CD34. The morphologic features and the immunoprofile were diagnostic of gastrointestinal stromal tumor. Herein, we present a rare case of gastric gastrointestinal stromal tumor with mature bone formation, osseous metaplasia and calcification. To the best of our knowledge, this is the second case report of gastric gastrointestinal stromal tumor with osseous differentiation and mature bone formation.

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Gastrointestinal Stromal Tumors of the Stomach with Extensive Calcification: Report of Two Cases

Cited by 6 publications

References 12 publications

Solid pseudopapillary tumor of the pancreas mistaken for gastrointestinal stromal tumor: A case report

Solid pseudopapillary tumor of the pancreas mistaken for gastrointestinal stromal tumor: A case report

Heavily calcified gastrointestinal stromal tumors: Pathophysiology and implications of a rare clinicopathologic entity

Gastric gastrointestinal stromal tumor with osseous differentiation and stromal calcification: A case report and review of literature

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