Gastrointestinal Stromal Tumour of Small Intestine Presenting as a Mesenteric Mass

Suryawanshi, Kishor H; Patil, Tushar; Damle, Rajshri P; Dravid, Nandkumar V; Surana, Akshay

doi:10.7860/jcdr/2014/8444.4475

Cited by 7 publications

(6 citation statements)

References 12 publications

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“…The key to diagnosis relies on pathology, including morphology, histology, and immunohistochemistry. Morphologically, GISTs are well-circumscribed tumours of varying size (0.5–8 cm on average but can be larger than 30 cm) and often accompanied by a pseudo-capsule containing hemorrhagic, necrotic, or cystic components ( 6 , 13 ). Histologically, GISTs are commonly described as spindle cell tumours, although they can also be epithelioid, or more rarely, mixed spindle cell/epithelioid ( 1 , 2 , 13 ).…”

Section: Discussionmentioning

confidence: 99%

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Case report: Desmoid fibromatosis diagnosed in a 27-year-old male after being mistaken for a gastrointestinal stromal tumour

Albino

Guo²,

Bacani³

et al. 2022

Front. Med.

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Despite being distinct lesions, gastrointestinal stromal tumours (GISTs) and desmoid fibromatosis may appear similar on imaging when they involve the stomach wall or bowel. As a result, they may be confused with one another when initially diagnosed. This report aims to present a case where a desmoid tumour was mistaken for a gastric GIST in a 27-year-old gentleman despite extensive investigation prior to exploratory laparotomy, and why differentiation through pathology, with a focus on the immunohistochemistry profile, is key for proper prognostication and appropriate management, including timely investigation for associated diseases such as Familial Adenomatous Polyposis in patients with desmoid tumours.

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Section: Discussionmentioning

confidence: 99%

“…Clinical presentation varies by tumour size, location, and aggressiveness, and can range from minimal symptoms to vague epigastric pain and early satiety. In severe cases, patients may present with acute bowel obstruction, volvulus, or infarction (3,(5)(6)(7). In addition, all 10.3389/fmed.2022.998473…”

Section: Introductionmentioning

confidence: 99%

Case report: Desmoid fibromatosis diagnosed in a 27-year-old male after being mistaken for a gastrointestinal stromal tumour

Albino

Guo²,

Bacani³

et al. 2022

Front. Med.

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“…Suryawanshi et al . [ 10 ] reported a case of gastrointestinal stromal tumor that presented as a mesenteric mass attached to the wall of ileum and presented as a case of sub-acute intestinal obstruction. Resection with negative margins (R0 resection) and without rupture of the pseudo-capsule or bleeding is the only recommended effective therapy for primary gastrointestinal stromal tumor in the absence of metastasis, if its technically feasible and risk of morbidity is acceptable with a long-term survival of up to 50% [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Primary mesenteric gastrointestinal stromal tumor presented with acute small bowel obstruction

Sembawa

2020

Journal of Surgical Case Reports

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Primary mesenteric gastrointestinal stromal tumors may give rise to abdominal emergencies like bowel obstruction and should be considered in the differential diagnosis to reduce morbidity and mortality. The present study presents an unusual case of primary mesenteric gastrointestinal stromal tumor presenting with small bowel obstruction. A 44-year-old healthy male presented with abdominal pain for 2 days. Detailed examination revealed presence of a 4 × 4 cm mass in the small bowel mesentery with multiple small bowel loops adherent to it, together with their mesentery. The patient was diagnosed with primary gastrointestinal stromal tumor of the small bowel mesentery. He had an uneventful postoperative course and was discharged on the second postoperative day in a good condition. The case analysis showed that the diagnosis of gastrointestinal stromal tumor is likely with the emergence of CD117, despite of its occurrence at rare sites and it is a vague clinical picture.

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“…Tumors located in these regions are known as extra-gastrointestinal stromal tumors ( 3 ). The peak incidence of GIST is in adulthood (median age, 63 years) with no evident gender predilection ( 4 ). GIST may vary considerably in size and tumors >10 cm in size are considered to be giant GISTs.…”

Section: Introductionmentioning

confidence: 99%

Giant and high-risk gastrointestinal stromal tumor in the abdomino-pelvic cavity: A case report

2016

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Gastrointestinal stromal tumors (GISTs) are benign mesenchymal tumors of the gastrointestinal tract. The clinical presentations of patients with GIST are variable and may be non-specific. The current study reports the case of a 66-year-old man that presented with a gradual enlargement of the abdomen, emaciation, hyperhidrosis and frequent and urgent micturition. A computed tomography (CT) scan of the abdomen revealed a large, heterogeneous, low density mass that occupied the entire abdomino-pelvic cavity. Magnetic resonance imaging (MRI) identified a high signal intensity on the T2 weighted image and an intermediate signal intensity on the T1 weighted image. A contrast enhanced CT scan and MRI demonstrated the uptake of contrast material. A biopsy revealed that the tumor was composed of spindle cells, and immunohistochemical analysis identified the presence of mast/stem cell growth factor receptors. Together, these results lead to a diagnosis of GIST. The clinical findings, imaging modalities and pathological studies suggested that the GIST was a large and high-risk tumor located in the abdomino-pelvic cavity. The final surgical results confirmed these findings. Following conservative treatment with imatnib (400 mg, daily) for 6 months, the tumor became smaller and was suitable for surgery, which the patient received in December 2014. The final surgery confirmed the high-risk GIST. Subsequent to the surgery, the patient was recommended to continue the use of imatnib with regular CT or MRI reexaminations every 3 months, which are planned to continue for 3 years.

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Gastrointestinal Stromal Tumour of Small Intestine Presenting as a Mesenteric Mass

Cited by 7 publications

References 12 publications

Case report: Desmoid fibromatosis diagnosed in a 27-year-old male after being mistaken for a gastrointestinal stromal tumour

Case report: Desmoid fibromatosis diagnosed in a 27-year-old male after being mistaken for a gastrointestinal stromal tumour

Primary mesenteric gastrointestinal stromal tumor presented with acute small bowel obstruction

Giant and high-risk gastrointestinal stromal tumor in the abdomino-pelvic cavity: A case report

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