Gastrointestinal stromal tumour of the pharynx

Ma, Siddiq; East, David; Yl, Hock; At, Warfield

doi:10.1258/002221504323012120

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…Mesenchymal tumours with similar clinicopathologic and molecular genetic profiles have been increasingly described in the omentum, mesentery and retroperitoneum as extra-gastrointestinal stromal tumours (EGISTs, [12][13][14]). Furthermore, very rare case reports documenting GIST-type tumours at such unusual sites as the gallbladder [15,16], the abdominal wall [17], the perivesical tissue [18,19], the pharynx [20], the posterior mediastinum [21], the liver [22] and the pancreas [23,24] appeared in the recent pathology literature. These unusual case reports reflected a loose application of the term EGISTs for heterogeneous neoplasms that may either be extramural gastrointestinal GISTs or possibly KIT-positive non-GISTs.…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal stromal tumours: a regular origin in the muscularis propria, but an extremely diverse gross presentation

Agaimy

Wünsch

2006

Langenbecks Arch Surg

125

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EGISTs are probably rarer than previously reported (1.5% or less in this study). We concluded that most so-called EGISTs represent apparent EGISTs that should have arisen from the outermost muscle coat, but have lost their contact to the point of origin due to extensive extramural growth pattern. From a surgical point of view, it is crucial to document and mark any focal attachment or adhesions to the gut wall noticed during surgery for an apparent EGIST. In contrast to most other neoplasms, GISTs should be defined by virtue of any degree of association with the muscularis propria (no matter how minimal), but not by localisation of the bulk of the tumour.

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Section: Introductionmentioning

confidence: 99%

Gastrointestinal stromal tumours: a regular origin in the muscularis propria, but an extremely diverse gross presentation

Agaimy

Wünsch

2006

Langenbecks Arch Surg

125

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“…16, 23, 25 In one case, the omental leiomyoma was associated with myomas in the uterus and a relationship between the uterine and the omental tumor was suspected. 26 In the other 2 reports, no uterine myomas were observed.…”

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confidence: 91%

“…27 Similarly, KIT-positive tumors, diagnosed as GISTs, have also been reported in humans at locations apart from the gastrointestinal tract, such as the pharynx and pancreas. 5,26,28 Furthermore, GISTs deriving from the omentum have been detected in humans. 8,9,16,18 However, the cellular origin of these so-called extragastrointestinal stromal tumors (EGISTs) is not known, and the occurrence of EGISTs is still discussed controversially.…”

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confidence: 99%

Omental Leiomyoma in a Male Adult Horse

Schaudien¹,

Muller

Baumgärtner³

2007

Vet Pathol

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Abstract. A well-circumscribed mass 70 3 35 3 28 cm in size and 41 kg in weight was detected at necropsy in a male adult horse within the omentum major without any association to the gastrointestinal tract. The tumor consisted of multiple white-to-yellow lobules and displayed a firm consistency. In addition, multiple cysts filled with blood-like fluid, and multifocal areas of necrosis were observed. Histologically, the mass consisted of slightly pleomorphic spindloid-shaped cells arranged in interlacing bundles containing elongated nuclei with blunt ends. The majority of tumor cells revealed a positive immunoreaction for a-smooth muscle actin, vimentin, and neuron-specific enolase and were negative for S-100, factor VIII-related antigen, and glial fibrillary acidic protein. Few tumor cells showed expression of desmin and c-kit. On the basis of macroscopy, histology, and immunohistochemistry, an omental leiomyoma was diagnosed.

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“…These types are called extra-GISTs (EGISTs) (4,5). Other less frequent anatomical locations have been reported as primary sites, such as the liver (6), mediastinum (7), pharynx (8) and gall bladder (9). ICClike cells, which are KIT-positive mesenchymal cells, have been reported in the omentum (10).…”

Section: Introductionmentioning

confidence: 99%

Rare gastrointestinal stromal tumors (GIST): omentum and retroperitoneum

Sawaki¹

2017

Transl. Gastroenterol. Hepatol.

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms that arise in the gastrointestinal tract and rarely elsewhere in the abdomen. GISTs that develop outside the digestive tract are called extra-GISTs (EGISTs). The incidence of EGISTs is reported to be approximately 10% of all GISTs, and the median age is younger than that of conventional GISTs. EGISTs have similar histology and immunohistochemical features as conventional GISTs, with the majority of them in the omentum and mesentery. Most GISTs harbor a kinase-activating mutation in either KIT or PDGFRA. For EGISTs, the incidence of this type of mutation is 40-50%, which is somewhat lower than for conventional GISTs. EGISTs may have a worse prognosis compared with conventional GISTs with high mitotic indices, large size, and distant metastasis including lymph node involvement. In large abdominal tumors, the visceral origin is almost impossible to discern.

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Gastrointestinal stromal tumour of the pharynx

Cited by 8 publications

References 7 publications

Gastrointestinal stromal tumours: a regular origin in the muscularis propria, but an extremely diverse gross presentation

Gastrointestinal stromal tumours: a regular origin in the muscularis propria, but an extremely diverse gross presentation

Omental Leiomyoma in a Male Adult Horse

Rare gastrointestinal stromal tumors (GIST): omentum and retroperitoneum

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