Gastrointestinal stromal tumours at Inkosi Albert Luthuli Central Hospital from 2005 to 2015

Abstract

Several genetic mutations are responsible for the pathogenesis of GIST. c-KIT and platelet-derived growth factor receptor alpha (PDGFRA) mutations are the commonest, occurring in 80% and Background: Gastrointestinal stromal tumour (GIST) is the commonest mesenchymal malignancy of the gastrointestinal tract. Patient demographics and outcomes following imatinib therapy in South Africa are unknown.Aim: To establish the patient demographics of GIST and the clinical outcomes following imatinib therapy.