Gastrointestinal sutureless anastomosis in pigs using absorbable intraluminal stents, stent placement devices, and fibrin glue - a summary

Abstract

The SAINT-PD has potential for all gastrointestinal sites, but needs larger experimental trials. The SS technique is impractical and had high tissue ridge formation and adhesion rates. These preliminary trials suggest the simplicity, versatility and safety of the SAINT technique; however, the small groups limit result interpretation. The results present a starting point for sutureless FG gastrointestinal anastomosis, and future experimental evaluation with more extensive statistical analyses in larger studies are needed.

Sutureless colonic anastomosis in the rat: a randomized controlled study

“…Thus, improvement of the anastomotic technique is a necessity. Non-suture colonic anastomosis has been the subject of many experiments [11][12][13][14][15][16][17]. Schafer et al [9] in a study on rabbits, demonstrated that suture-induced disturbances of the intestinal microcirculation lead to necrosis of the mucosa, partial and incomplete necrosis of the inverted cuff, and transmural necrosis with destruction of the sero-serous contact zone, leading to anastomotic leakage.…”

“…Kirkegaard et al [12] in an experimental study in rats found much more intestinal adhesions causing intestinal obstruction in the isobutylcyanoacrylate group. Detweiler et al [14] proposed the combination of absorbable intraluminal stents and fibrin glue in order to avoid adhesion formation and intestinal obstruction. Detweiler et al [14] proposed the combination of absorbable intraluminal stents and fibrin glue in order to avoid adhesion formation and intestinal obstruction.…”

Colorectal anastomotic leak rates are measures of technical skill in surgery

“…A sutureless anastomosis using fibrin glue is still in the experimental phase 33 and the laser, while capable of achieving union, may not (in animal experiments) produce a robust one 34…”

A Simple Method of Intestinal Anastomosis (Ileocolostomy) in Rats

“…In gastrointestinal tract surgery, there may be complications after anastomotic operations such as leaks, adhesions, stenosis and abscess formation at the anastomotic site [1,4,18,19,25]. In a pilot experiment, we made an incision in the colon and introduced about 2 cm of the ileum into the colonic lumen as described earlier.…”