Gastrointestinal symptoms and endoscopy findings after pediatric solid organ transplantation: A case series

Ylinen, Elisa; Merras‐Salmio, Laura; Jahnukainen, Timo

doi:10.1111/petr.14374

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…Thus, gastrointestinal symptoms after solid organ or hematopoietic stem cell transplantation should raise the suspicion of PTLD and lead to gastrointestinal exploration, especially if EBV replication is present. 4,5 The classic endoscopic features of gastrointestinal PTLD are erythematous raised lesions with a central ulceration. 6 Any delay in diagnosis may expose patients to life-threatening complications such as hemorrhage or perforation.…”

Section: Pediatric Post-transplant Lymphoproliferative Disorder: Do N...mentioning

confidence: 99%

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Pediatric post‐transplant lymphoproliferative disorder: Do not overlook digestive involvement

Calvez

Samarji

Hubert

et al. 2023

Pediatric Blood & Cancer

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Section: Pediatric Post-transplant Lymphoproliferative Disorder: Do N...mentioning

confidence: 99%

“…This research is funded by the non-profit organization Etoile de Martin/SFCE. Baptiste Le Calvez 1,2 Batoul Samarji 3 Gervaise Hubert 1 Eric Lagrue 4 Marion Eveillard 5…”

Section: Conflict Of Interest Statementmentioning

confidence: 99%

Pediatric post‐transplant lymphoproliferative disorder: Do not overlook digestive involvement

Calvez

Samarji

Hubert

et al. 2023

Pediatric Blood & Cancer

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“…Establishing a PTLD diagnosis can be difficult and occasionally multiple attempts for getting conclusive tissue biopsies are necessary (especially for gastrointestinal PTLD). In SOT recipients with persistent gastrointestinal symptoms, PTLD should be part of the differential diagnosis and endoscopy with biopsy of ulcers/lesions should be performed [106].…”

Section: Diagnosis Of Post-transplant Lymphoproliferative Disorders (...mentioning

confidence: 99%

Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients

Atamna,

Yahav,

Hirzel

2023

Transpl Int

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Long-term risk for malignancy is higher among solid organ transplant (SOT) recipients compared to the general population. Four non-hepatitis viruses have been recognized as oncogenic in SOT recipients—EBV, cause of EBV-associated lymphoproliferative diseases; human herpes virus 8 (HHV8), cause of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease; human papilloma virus, cause of squamous cell skin cancers, and Merkel cell polyomavirus, cause of Merkel cell carcinoma. Two of these viruses (EBV and HHV8) belong to the human herpes virus family. In this review, we will discuss key aspects regarding the clinical presentation, diagnosis, treatment, and prevention of diseases in SOT recipients associated with the two herpesviruses.

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“…A few years after the widespread use of hematopoietic and solid organ transplantation, several reports were published regarding the effect of transplantation on pre-existing intestinal diseases and the development of new post-transplant IBD, commonly referred to as de novo IBD (5)(6)(7). The incidence of IBD and other causes of intestinal inflammation after transplantation is higher in Orthotopic Liver Transplantation (OLT) patients than in the general population (8,9). About 30% of patients with IBD experience improvement after LT, while an equal percentage experience worsening.…”

Section: Introductionmentioning

confidence: 99%

“…Immunosuppressive drugs have been known to have multiple effects on the intestinal epithelium and the intestinal immune system. These effects can result in immune dysfunction and gastrointestinal inflammation in OLT patients (8,11).…”

Section: Introductionmentioning

confidence: 99%

De Novo Inflammatory Bowel Disease after Liver Transplantation: Eleven Years' Experience in Shiraz, Iran

Paridar,

Kassani

2024

J Adv Immunopharmacol

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Background: Inflammation may occur after solid and liquid liver transplantations at a rate higher than in the general population. Objectives: This study aimed to investigate the incidence of de novo inflammatory bowel disease (IBD) and assess some risk factors after Orthotopic liver transplantation (OLT) in liver transplant patients in Shiraz, Iran. Methods: The sample study comprised patients (n = 1702) who had received liver transplants between 2001 and 2012 at the Shiraz liver transplant center. The data were obtained from patient records, which included information on their medical history, colonoscopy reports, family history of IBD, and other risk factors. The study evaluated the status of inflammatory bowel disease (IBD) among patients who had undergone liver transplantations due to autoimmune hepatitis group (AIH), Primary Sclerosing Cholangitis (PSC), and other liver transplant patients. Additionally, case groups were formed, comprising AIH patients (n1 = 10) and other patients with IBD (n2 = 10), and were compared with transplant patients without IBD as the control group (n1 = 21, n2 = 21). Results: Out of the total 1702 patients, 254 (14.92%) had AIH, 211 (12.40%) had PSC, and 1237 (72.68%) had other outcomes. The mean of leukocyte counts (P-value = 0.73), types of immunosuppressant medications, and serum levels of cyclosporine (P-value = 0.77) and tacrolimus (P-value = 0.27) did not show any significant differences between the case and control groups. However, it was observed that IBD developed earlier in patients with AIH compared to other patients (20.1 ± 2.23 vs 53.9 ± 4.42 months). Conclusions: The incidence of IBD after liver transplantation was higher compared to the general population, and it occurred earlier in patients who underwent transplantation for AIH and other groups.

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Gastrointestinal symptoms and endoscopy findings after pediatric solid organ transplantation: A case series

Abstract: Background: Gastrointestinal symptoms are common among solid organ transplant (SOT) recipients. Information about colonoscopy findings after pediatric SOT is limited. This retrospective study reports endoscopy findings in a nationwide pediatric transplant recipient cohort.

Cited by 4 publications

References 29 publications

Pediatric post‐transplant lymphoproliferative disorder: Do not overlook digestive involvement

Pediatric post‐transplant lymphoproliferative disorder: Do not overlook digestive involvement

Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients

De Novo Inflammatory Bowel Disease after Liver Transplantation: Eleven Years' Experience in Shiraz, Iran

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