Gastrointestinal Symptoms of Food Challenge‐proven Non‐IgE Cow's Milk Allergy Are Dissipated by Early School Age

Helin, Noora; Kolho, Kaija‐Leena; Qvist, Erik; Mäkelä, Mika J.; Merras‐Salmio, Laura

doi:10.1097/mpg.0000000000001737

Cited by 3 publications

(4 citation statements)

References 38 publications

(52 reference statements)

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“…It may be that the observed difference between the three groups is thus more attributable to the original IgE sensitisation than CMA itself, but the number of patients in the subanalysis was too small to draw any firm conclusions. Previous studies support the idea that non–IgE‐mediated CMA is a benign condition that is not associated with an increased risk of atopic diseases 23 …”

Section: Discussionmentioning

confidence: 70%

“…Previous studies support the idea that non-IgEmediated CMA is a benign condition that is not associated with an increased risk of atopic diseases. 23 We observed that subjects with AE and CMA in infancy, compared with those with AE only, and unselected controls, had a higher lifetime prevalence of certain allergic symptoms: wheeze, noninfectious rhinitis and hay fever. For wheeze and noninfectious rhinitis, as well as rhinitis symptoms in the past 12 months, the associated aOR was significantly higher in the AE/CMA+ group compared with controls, but not in the AE/CMA− group compared with controls.…”

Section: Discussionmentioning

confidence: 73%

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Allergic symptoms and sensitisation in adolescents with cows' milk allergy and atopic eczema in infancy

Piippo

Viljanen

Savilahti

et al. 2020

Immunity Inflam & Disease

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Background: The association between atopic sensitisation, atopic eczema (AE) and asthma is known, but distinct roles of allergies on long-term health are unestablished. Objective: Evaluation of allergic symptoms and sensitisation in adolescents who in infancy had AE and verified cows' milk allergy (CMA) or AE and a negative CMA challenge, and controls. Methods: Children with AE, with and without CMA, from a randomised controlled study in 1999-2001 examining the effect of probiotics on AE severity at older than 12 months of age, attended a follow-up visit at age 16 to 18, with agematched controls. Data came from a questionnaire (ISAAC questionnaire), analysis of serum antigen-specific immunoglobulin Es (IgEs), and clinical evaluation. Group comparisons were carried out (χ 2 tests and logistic regression). Results: Fifty-two patients with AE and CMA (AE/CMA+ group), 52 with AE and suspicion of CMA (AE/CMA− group), and 57 controls attended a study visit. IgE-mediated sensitisation was significantly more prevalent in the AE/CMA+ group vs the controls, for horse, cat, dog, egg white and wheat (P < .024 for all). For birch, timothy and mugwort (P < .008 for all), sensitisation was more prevalent in both the AE/CMA+ group and the AE/CMA− group vs controls. On the basis of questionnaire data the AE/CMA + group reported a significantly higher lifetime prevalence of wheezing (64% vs 35% and 32%; P = .001), noninfectious rhinitis (85% vs 62% and 56%; P = .004), and hay fever (77% vs 52% and 33%; P < .001) vs the AE/CMA− group and the control group, respectively. Conclusion and Clinical Relevance: Patients with AE and CMA in infancy, as opposed to patients with AE only, or controls, report more allergic symptoms and exhibit more allergic sensitisation in adolescence. This indicates that CMA in infancy is an independent risk factor of allergic disease in adolescence.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 73%

Allergic symptoms and sensitisation in adolescents with cows' milk allergy and atopic eczema in infancy

Piippo

Viljanen

Savilahti

et al. 2020

Immunity Inflam & Disease

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“…After the removal of duplicates and screening the abstracts of the remaining publications, 21 papers underwent full-text screening (Figure 1). Eleven of these were excluded (Table S1), [28][29][30][31][32][33][34][35][36] and 10 papers containing quantitative data on feeding difficulties were included in our systematic data analysis (Figure 1). 9,16,[37][38][39][40][41][42][43][44] We found no interventional studies in this systematic review.…”

Section: Search Resultsmentioning

confidence: 99%

Feeding difficulties in children with food allergies: An EAACI Task Force Report

Hill,

Nurmatov,

DunnGalvin

et al. 2024

Pediatric Allergy Immunology

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The term “feeding difficulties” refers to a spectrum of phenotypes characterized by suboptimal intake of food and/or lack of age‐appropriate eating habits. While it is evident that feeding difficulties are prevalent within healthy children, no consensus has been reached for those with food allergies. The aim of this study was to systematically review all the available literature reporting the prevalence of feeding difficulties within food allergic children. We searched eight international electronic databases for all published studies until June 2022. International experts in the field were also contacted for unpublished and ongoing studies. All publications were screened against pre‐defined eligibility criteria and critically appraised by established instruments. The substantial heterogeneity of included studies precluded meta‐analyses, so narrative synthesis of quantitative data was performed. A total of 2059 abstracts were assessed, out of which 21 underwent full‐text screening and 10 studies met the study criteria. In these, 12 different terms to define feeding difficulties and 11 diagnostic tools were used. Five papers included data of feeding difficulty prevalence in children with food allergies, ranging from 13.6% to 40%. Higher prevalence was associated with multiple food allergies. The current literature suggests that feeding difficulties are prevalent within food allergic children, particularly those with multiple food allergies. However, the heterogeneity of terminologies and diagnostic tools makes drawing conclusions challenging. Consensus guidelines for the diagnosis and management of feeding difficulties within food allergic children and further research on the development and perpetuation of feeding difficulties are needed to appropriately manage such patients.

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“…It was contended that too strict definitions may underestimate the incidence of CMA [7]. In any case, the condition presents an early resolution in the majority of cases, in particular the non-IgEmediated forms [5,6,8] 3. Non-IgE-mediated CMA and its gastrointestinal manifestations CMA is a spectrum of conditions ranging from the immediate.…”

Section: Epidemiology and Natural History Of Cmamentioning

confidence: 99%

What’s next for DRACMA?

Dahdah

Fierro

Mennini

et al. 2018

Expert Review of Clinical Immunology

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Gastrointestinal Symptoms of Food Challenge‐proven Non‐IgE Cow's Milk Allergy Are Dissipated by Early School Age

Cited by 3 publications

References 38 publications

Allergic symptoms and sensitisation in adolescents with cows' milk allergy and atopic eczema in infancy

Allergic symptoms and sensitisation in adolescents with cows' milk allergy and atopic eczema in infancy

Feeding difficulties in children with food allergies: An EAACI Task Force Report

What’s next for DRACMA?

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