Gastrointestinal tissue diagnosis by laser-induced fluorescence spectroscopy at endoscopy

Cothren, Robert M.; Richards‐Kortum, Rebecca; Sivak, Michael; Fitzmaurice, Maryann; Rava, Richard P.; Boyce, Gregory A.; Doxtader, Mark M.; Blackman, Ronald K.; Ivanc, Thomas B.; Hayes, Gary B.; Feld, Michael S.; Petras, Robert E.

doi:10.1016/s0016-5107(90)70961-3

Cited by 279 publications

(153 citation statements)

References 13 publications

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“…Such investigations have demonstrated contrast in a variety of tissue types including: between normal tissue and adenomatous (i.e. neoplastic) polyps ex vivo [27][28][29]; between normal tissue and adenomas in vivo [30]; between normal tissue or hyperplastic polyps and adenomas [31]; between hyperplastic polyps and adenomas [32,33]; and between all three of the above tissue groups [34]. Cancers in the upper GI tract (esophagus and stomach) have also been investigated [35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe

Coda¹,

Thompson²,

Kennedy³

et al. 2014

Biomed. Opt. Express

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Abstract:We present an ex vivo study of temporally and spectrally resolved autofluorescence in a total of 47 endoscopic excision biopsy/resection specimens from colon, using pulsed excitation laser sources operating at wavelengths of 375 nm and 435 nm. A paired analysis of normal and neoplastic (adenomatous polyp) tissue specimens obtained from the same patient yielded a significant difference in the mean spectrally averaged autofluorescence lifetime −570 ± 740 ps (p = 0.021, n = 12). We also investigated the fluorescence signature of non-neoplastic polyps (n = 6) and inflammatory bowel disease (n = 4) compared to normal tissue in a small number of specimens. References and links1. R. Lambert, H. Saito, and Y. Saito, "High-resolution endoscopy and early gastrointestinal cancer...dawn in the East," Endoscopy 39(3), 232-237 (2007

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Section: Introductionmentioning

confidence: 99%

Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe

Coda¹,

Thompson²,

Kennedy³

et al. 2014

Biomed. Opt. Express

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“…In cases of preinvasive disease (carcinoma in situ) or microscopic invasive disease, the airway can appear normal to white light, but will display irregularities when illuminated by light with a wavelength of 380-440 nm (blue spectrum) [Hung et al 1991]. This difference in autofluorescence is accounted for by the fact that dysplastic epithelium has thicker and more complex tissue architecture than normal epithelium [Cothren et al 1990]. When combined with white light bronchoscopy, AFB improves the sensitivity of detecting high-grade dysplasia from 46% to 86% [Edell et al 2009].…”

Section: Autofluorescence Bronchoscopymentioning

confidence: 99%

Bronchoscopic staging of lung cancer

Hanna

Yasufuku

2012

Ther Adv Respir Dis

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Advances in bronchoscopy have contributed valuable tools to the diagnosis and staging of lung cancer. Detection of lesions at the premalignant microscopic stage has become possible with autofluorescence bronchoscopy and narrow band imaging. Bronchoscopy also allows for sampling of visible intra-bronchial lesions and for transbronchial needle aspiration of lesions in pulmonary parenchyma. With endobronchial ultrasound guidance, real-time evaluation and biopsy of mediastinal and pulmonary lesions can be achieved, enabling accurate clinical and pathological T-staging and N-staging without the need for surgery. In combination with advanced imaging techniques, Navigational bronchoscopy allows for the targeting and biopsy of the most peripheral lesions that are located in the smallest airways. For patients in whom tumor genetics are important, bronchoscopic-guided transbronchial biopsy can provide sufficient material for molecular analysis. As minimally invasive technology continues to evolve and improve, bronchoscopic techniques are poised to continue to be essential for the diagnosis and staging of lung cancer.

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“…There are many reports that in the gastrointestinal tract the autofluorescence spectra of dysplasia and carcinomas are significantly different from those of normal mucosa [3][4][5][6][7][8][9][10]. Based on the LIFE-Lung system, an autofluorescence imaging system for the gastrointestinal (GI) tract (LIFE-GI) has been newly developed by Xillix and Olympus based on the need for a more sensitive and specific method of real time detecting early cancer or precancerous lesion in the GI tract.…”

Section: Introductionmentioning

confidence: 99%

Clinical Experience Using a Real Time Autofluorescence Endoscopy System in the Gastrointestinal Tract

Ogihara

Watanabe

Namihisa

et al. 1999

Diagnostic and Therapeutic Endoscopy

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Autofluorescence spectra of neoplastic tissues have been reported to be significantly different from those of normal tissues when excited by blue or violet light. From this concept, a lightinduced autofluorescence endoscopic imaging system for gastrointestinal mucosa (LIFE-GI; Xillix, Canada and Olympus, Japan) has been newly developed and the clinical evaluation of the prototype system has been conducted in hospitals in Canada, Netherlands and Japan.We examined the clinical usefulness of the prototype LIFE-GI system for the detection of gastrointestinal cancer and high and low grade dysplasia. The LIFE-GI system was also applied to the early detection of remnant lesions after endoscopic treatment of early gastric cancer and to the detection of laterally spreading superficial colonic tumors.This system has potential application for the diagnosis of dysplastic lesions and early cancers in the gastrointestinal tract as an adjunct to ordinary white light endoscopy. This system, which needs no administration of a photosensitive agent, may be suitable as a screening method for the early detection of neoplastic tissues.

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Gastrointestinal tissue diagnosis by laser-induced fluorescence spectroscopy at endoscopy

Cited by 279 publications

References 13 publications

Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe

Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe

Bronchoscopic staging of lung cancer

Clinical Experience Using a Real Time Autofluorescence Endoscopy System in the Gastrointestinal Tract

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