Gastrointestinal Tract

Betton, Graham; Whiteley, Larry; Anver, Miriam R.; Brown, R.; Deschl, Ulrich; Elwell, Michael R.; Germann, Paul-Georg; Härtig, Florian; Küttler, Karin; Mori, Hideki; Nolte, Thomas; Püschner, H.; Tuch, K.

doi:10.1007/978-3-662-07973-7_2

Cited by 9 publications

(11 citation statements)

References 16 publications

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“…Since tumor cells of basal cell adenoma/carcinoma are mainly composed of basaloid cells, this tumor was unlikely to belong to that category. Adenocarcinomas of the mouse were reported to have a structure very similar to those of the present cases 2,6 . The solid growth area in our cases was unlikely to be composed of poorly differentiated luminal cells, since tumor cells in the solid area were uniformly positive for SMA and vimentin, but negative for cytokeratin 14 and 19.…”

supporting

confidence: 74%

“…Pleomorphic adenoma is one of the most common neoplasms of human salivary gland, and characterized by the proliferation of morphological two types of tumor cells consisting of luminal and myoepithelial cells 3 . However, the term pleomorphic adenoma has not been used for the classification of rodent tumor 2 . We encountered two cases of salivary gland tumor in the Prairie dog (Cynomys ludovicianus), a member of the family Rodentia.…”

mentioning

confidence: 99%

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Pleomorphic Adenoma of the Salivary Gland in Two Prairie Dogs (Cynomys ludovicianus)

Ozaki

Narama

2003

J Toxicol Pathol

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Abstract:Two masses adjacent to the salivary glands of two Prairie dogs which were surgically removed and examined histopathologically as well as immunohistochemically, were diagnosed as pleomorphic adenomas. Histologically, each mass had a thin fibrous capsule, compressed surrounding tissue, and was lobulated by delicate connective tissue. The lobules mainly consisted of a solid growth of small ovoid-to spindle-shaped cells, and contained small duct or tubule lined with monolayered cuboidal epithelial cells. The amount of connective tissue stroma varied in different parts of the tumor mass, accompanied occasionally by a myxomatous stroma-rich area. Tumor cells in the solid growth area had indistinct cell borders, and usually showed spindle-like features resembling myoepithelial cells. Mitosis was prominent, whereas cellular pleomorphism was not seen. Tumor cells forming the tubular structure were positive for cytokeratin 19 and negative for smooth muscle actin (SMA), while the ovoid-to spindle-shaped tumor cells of the solid growth area were positive for SMA and negative for cytokeratin 19. Our results indicated that immunostaining was a useful and powerful method for the diagnosis of cell differentiation of salivary gland tumor cells. (J Toxicol Pathol 2003; 16: 171-173)

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supporting

confidence: 74%

mentioning

confidence: 99%

Pleomorphic Adenoma of the Salivary Gland in Two Prairie Dogs (Cynomys ludovicianus)

Ozaki

Narama

2003

J Toxicol Pathol

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“…Tissue sections of the small intestine were stained with hematoxylin and eosin (HE) for histopathological examination. The evaluation of the neoplastic proliferative lesions was performed according to the international classification of rodent tumors .…”

Section: Methodsmentioning

confidence: 99%

Effects of Nrf2 silencing on oxidative stress‐associated intestinal carcinogenesis in mice

et al. 2016

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To assess the risk of colorectal cancer in humans with inactivation of NRF2, Nrf2‐proficient (Nrf2 +/+) and ‐deficient (Nrf2 −/−) mice were exposed to potassium bromate (KBrO3) at concentrations of 750 or 1500 ppm for 52 weeks. Neoplastic proliferative lesions were observed in the small intestine and exhibited accumulations of β‐catenin and cyclin D1. The lesions had characteristics similar to those in experimental models of human hereditary colorectal cancer. An additional 13‐week study was performed to examine the role of Nrf2 in the effects of oxidative stress. Significant increase in combined incidences of preneoplastic and neoplastic lesions in Nrf2 −/− mice administered high‐dose KBrO3. In the short‐term study, although 8‐hydroxydeoxyguanosine (8‐OHdG) levels in the epithelial DNA of Nrf2 −/− mice at the high dose were significantly lower than those of the corresponding Nrf2 +/+ mice, the difference was very small. mRNA levels of Nrf2‐regulated genes were increased in Nrf2 +/+ mice. Overexpression of cyclooxygenase 2 (COX2) and increased numbers of proliferating cell nuclear antigen (PCNA)‐positive cells in the jejunal crypts were observed in Nrf2 −/− mice administered high‐dose KBrO3. Overall, these data suggested that individuals having single‐nucleotide polymorphisms in NRF2 may have a risk of colorectal cancer to some extent.

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“…The polygonal to spindloid morphology of the neoplastic cells, unencapsulated nature of the tumor, numerous necrotic pseudocystic spaces, and lack of acinar or ductular structures are features commonly seen in malignant myoepitheliomas and undifferentiated carcinomas of rodents and domesticated animals. 1,9 The lack of acinar or ductular structures is the key feature for differentiation from adenocarcinoma in this case.…”

mentioning

confidence: 83%

“…3,17 These tumors can become quite large, with pseudocystic chambers containing serous fluid, and are composed of large, pleomorphic spindle cells with epithelial and mesenchymal features. 1 Myoepitheliomas arise from myoepithelial cells of various exocrine glands and can exhibit a dual epithelial and contractile phenotype, confirmed by immunohistochemistry or electron microscopy. In general, normal and neoplastic myoepithelial cells are immunoreactive for S100, contain actin and PTAH-positive filaments, and express the intermediate filaments vimentin and cytokeratin.…”

mentioning

confidence: 94%

Undifferentiated Carcinoma of the Salivary Gland in a Chinchilla (Chinchilla Lanigera)

et al. 2010

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Abstract.A 12-year-old chinchilla (Chinchilla lanigera) developed a slow-growing, soft, fluctuating, nonpainful mass on the ventral neck with focally extensive alopecia over a period of approximately 8 months. On postmortem examination, an extensive, multilobulated, cystic, neoplastic mass extended subcutaneously over the ventral and lateral neck with metastatic spread to submandibular lymph nodes, spleen, liver, and lungs. Neoplastic cells were strongly positive for vimentin and pan-cytokeratin but were negative for alphasmooth muscle actin, S100, and myosin; no intracytoplasmic myofibrils were detected on phosphotungstic acid hematoxylin staining. Histologic and immunohistochemical examination of the mass led to a diagnosis of undifferentiated carcinoma of the salivary gland and contributes to the paucity of knowledge concerning neoplasia in chinchillas.

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Gastrointestinal Tract

Cited by 9 publications

References 16 publications

Pleomorphic Adenoma of the Salivary Gland in Two Prairie Dogs (Cynomys ludovicianus)

Pleomorphic Adenoma of the Salivary Gland in Two Prairie Dogs (Cynomys ludovicianus)

Effects of Nrf2 silencing on oxidative stress‐associated intestinal carcinogenesis in mice

Undifferentiated Carcinoma of the Salivary Gland in a Chinchilla (Chinchilla Lanigera)

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