Gastrointestinal Tract Complications of Diabetes Mellitus

Interindividual variation in the absorption of glibenclamide in man

“…However, autonomie nerve function as assessed by the CV% of R-R intervals was signifi¬ cantly impaired in the delayed absorption group compared with the rapid absorption group. It is reasonable to interprete that impaired autonomie nerve function could have caused a delayed ab¬ sorption of glibenclamide through delayed gastric empting and/or abnormal gastric acid secretion (Clarke et al 1979;Yang et al 1984), though other causes including genetic factor as reported in the metabolism of tolbutamide (Scott & Poffen-barger 1979) cannot be excluded. In most of the patients in the delayed absorption group, serum concentration of glibenclamide increased rapidly at 4 h after the patients took lunch.…”

Gastrointestinal Transit Disorders in Patients with Insulin-Treated Diabetes mellitus

“…Delayed esophageal and gastric emptying has been increasingly recognized as a frequent phenomenon in patients with long-standing insulin-requiring diabetes mel litus associated with various complications such as autonomic and peripheral neuropa thy. retinopathy and nephropathy [1][2][3], Al though lower tract symptoms, such as diar rhea, malabsorption, constipation, colonic dilatation and fecal incontinence, are wellknown and sometimes troublesome compli cations in diabetics [4,5], the pathogenetic mechanisms leading to these intestinal disor ders are largely unknown and systematic studies investigating the motility and transit disorders of the small and large intestine in diabetics are rare [6][7][8]. As previous studies have predominantly focused on one segment of the gut, namely the esophagus or the stom ach, it is hardly possible to predict the true extent of gastrointestinal dysfunction in such patients.…”

“…Diabetics Diabetics w ithout AN w ith AN n = 17 n r 26 bility to gastrointestinal infections and al tered gut hormone release have been sug gested to account for impaired gastrointesti nal motor function in diabetes mellitus [5,13]. However, the pathogenesis of gastroin testinal tract involvement in diabetes melli tus is poorly understood and previous stud ies predominantly concentrating on one or gan system have produced some conflicting results.…”

Diabetic Gastroparesis

“…When symptoms are present, they may include anorexia, nausea, vomiting, ab dominal pain, early satiety, heartburn, bloat ing, halitosis, and weight loss [5,7,8]. Vomitus may contain food ingested several hours earlier [4], The duration of symptoms is vari able and may last for several weeks or may be of short duration separated by symptom-free intervals [8,9]. There is no correlation be tween gastric emptying by radiolabeled scinti graphy and upper gastrointestinal symptoms in diabetics with gastroparesis [6,10,11].…”