Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer

Francis, Roshane; Guo, Haiyang; Streutker, Catherine; Ahmed, Musaddeque; Yung, Theodora; Dirks, Peter B.; He, Housheng Hansen; Kim, Tae-Hee

doi:10.1126/sciadv.aax8898

Cited by 31 publications

(35 citation statements)

References 49 publications

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“…circRNAs act as tumor suppressors in BC. The abnormal activation of transcription factors promotes the proliferation and differentiation of tumor cells (24). For instance, ΔNP63, a transcription factor of the p53 family, is upregulated by circ family with sequence similarity 114 member A2 (FAM114A2), thus suppressing the miR-762-induced growth of urothelial carcinoma of the bladder.…”

Section: Circrnas In Bcmentioning

confidence: 99%

Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)

Yang

Zou

et al. 2021

Mol Med Rep

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Circular RNAs (circRNAs) are a class of non-coding RNAs formed by covalently closed loops through back-splicing and exon-skipping. circRNAs have been confirmed to play a vital role in various biological functions, acting as microRNA sponges and reservoirs, as well as combining with RNA-binding proteins during the progression of multiple cancer types. Therefore, the present review evaluated recent research articles in PubMed that were published between November 2017 and September 2020. Key word search strings included: ‘Circular RNA (circRNA) AND bladder cancer (BC)’, ‘circular RNA (circRNA) AND prostate cancer (PCa)’ and ‘circular RNA (circRNA) AND renal cell cancer (RCC)’. In total, >58 circRNAs were found to be implicated in urological cancers, with several of the circRNAs targeting common carcinogenic pathways, such as the AKT, TGF-β, MAPK, VEGF and even metabolic pathways. circRNAs are important modulators of BC, PCa and RCC. circRNAs are functionally implicated in the pathogenesis of these cancer types, and have been found to act as biomarkers for the diagnosis and prognosis of urological cancer. However, to the best of our knowledge, the functions of circRNAs in tumors of the urinary system remain largely unknown and require further research.

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Section: Circrnas In Bcmentioning

confidence: 99%

Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)

Yang

Zou

et al. 2021

Mol Med Rep

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“…1,2 The early stage of gastric cancer has no specific manifestations and lacks sensitive serum indicators, and most patients are already in the advanced stage when diagnosed with poor prognosis. 3,4 Gastric cancer is a complex disease caused by many factors such as heredity and environment. Gene mutation, 5,6 loss of tumor suppressor and abnormal regulation of cell proliferation signaling pathway are all related to the occurrence and development of gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

<p>RPL38 Regulates the Proliferation and Apoptosis of Gastric Cancer via miR-374b-5p/VEGF Signal Pathway</p>

Ji¹,

Zhang²

2020

OTT

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Aim: To explore the role of RPL38 on proliferation and apoptosis of gastric cancer cells by regulating miR-374b-5p/VEGF signal pathway. Methods: qRT-PCR was used to measure the expression of RPL38. CCK8 assay, Matrigel invasion assay, and flow cytometry were used to detect the role of RPL38in MKN-45 cells. Western blot was used to measure the protein expression of VEGF, pERK , ERK, p-AKT, AKT in cells. Dual-luciferase assay was performed to verify the relationship between miR-374b-5p and RPL38, miR-374b-5p and VEGF. Results: In our research, we found that RPL38 was upregulation in gastric cancer, loss function of RPL38 could inhibit MKN-45 cell proliferation and invasion, accompany with increasing apoptosis. Then, we verified that RPL38 could interact with miR-374b-5p by performed luciferase assay, there was a negative correlation between RPL38 and miR-374b-5p. Furthermore, we observed that VEGF is a potential target of miR-374b-5p, miR-374b-5p negatively regulated the expression of VEGF, and effected ERK/AKT signal pathways. Next, we found that miR-374b-5p inhibitor or overexpression of VEGF could prevent the antitumor function of si-RPL38. Conclusion: Knockdown of RPL38 inhibits the proliferation and apoptosis of gastric cancer via miR-374b-5p/VEGF signal pathway.

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“…The pervasive antagonistic coevolution is a potentially critical mechanism that drives the animal kingdom (~7.77 million species (Mora et al, 2011;Strain, 2011)) to engender far more diverse species compared to the plant kingdom (~298K species (Mora et al, 2011)) under continual natural selection. Growing evidence shows that both tumors (Francis et al, 2019;Jin et al, 2019;Perera et al, 2016) and ageing (Janes et al, 2018;O'Callaghan and Vassilopoulos, 2017;Stegeman and Weake, 2017) are correlated with the interactions of promoters and TFs. The promoter-TF coevolutionary trajectories in the animal kingdom will shed further light on the mechanisms underlying tumor initiation and progression as well as human ageing, which are yet to be fully understood.…”

Section: Discussionmentioning

confidence: 99%

The Coevolution of Promoters and Transcription Factors in Animal and Plant Cells

Zhang

et al. 2020

Preprint

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Coevolution has been acknowledged to play a significant role in driving the evolution of molecules and species. Promoters and transcription factors (TFs), especially their interactions, are key determinants for the regulation of gene expression. However, the evolutionary processes and mechanisms of promoter and TF interactions are still poorly understood. Here we conduct extensive physicochemical analyses of multi-omics sequences in 440 animal species and 223 plant species which span nearly one billion years of phylogeny. We demonstrate that promoters and TFs obey antagonistic coevolution in the animal kingdom while follow mutualistic coevolution in the plant kingdom. Furthermore, we reveal that such two coevolutionary strategies result in different evolutionary transitions of transcriptional networks in the two kingdoms. These results suggest that the two distinct coevolutionary mechanisms are likely to be major drivers of far greater genetic divergence between animals and plants, and open a new door to understanding the roles of promoters and TFs in tumor initiation and progression, and human ageing as well in molecular interactions and evolution.

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Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer

Cited by 31 publications

References 49 publications

Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)

Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)

<p>RPL38 Regulates the Proliferation and Apoptosis of Gastric Cancer via miR-374b-5p/VEGF Signal Pathway</p>

The Coevolution of Promoters and Transcription Factors in Animal and Plant Cells

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