Gastrointestinal transit times and motility in patients with cystic fibrosis

Hedsund, Caroline; Gregersen, Tine; Joensson, Iben Moeller; Olesen, Hanne Vebert; Krogh, Klaus

doi:10.3109/00365521.2012.699548

Cited by 47 publications

(32 citation statements)

References 29 publications

(47 reference statements)

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“…A previous magnet based system employing a permanent magnet has been used in several studies of GI motility in health and disease . When magnet tracking was combined with simultaneous capsule endoscopy, it showed that tracking of a magnet, provide reliable information about GE and SITT .…”

Section: Discussionmentioning

confidence: 99%

Pilot study trialling a new ambulatory method for the clinical assessment of regional gastrointestinal transit using multiple electromagnetic capsules

Haase

Gregersen

Schlageter³

et al. 2014

Neurogastroenterology Motil

171

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Section: Discussionmentioning

confidence: 99%

Pilot study trialling a new ambulatory method for the clinical assessment of regional gastrointestinal transit using multiple electromagnetic capsules

Haase

Gregersen

Schlageter³

et al. 2014

Neurogastroenterology Motil

171

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show abstract

“…The same problem has been encountered in studies of adult patients, but the limitations were to some extent avoided by calculating the velocity of the magnetic pill during the first hours after pyloric passage. This approach is not ideal, but has allowed us to identify abnormalities in patients with spinal cord injury,16 systemic sclerosis,15 cystic fibrosis,28 and carcinoid syndrome 17. Compared with gastric emptying and small intestinal transit times, colorectal transit time is usually much longer.…”

Section: Discussionmentioning

confidence: 99%

Magnet tracking allows assessment of regional gastrointestinal transit times in children

Hedsund¹,

Joensson²,

Gregersen³

et al. 2013

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BackgroundData on small intestinal transit time in healthy children are lacking, and normal values for gastric emptying and colonic transit time are sparse. Conventional methods, including radiopaque markers, scintigraphy, and PillCam™ involve radiation or require the child to swallow a large pill. The minimally invasive, radiation-free Motility Tracking System-1 (MTS-1) has been introduced for description of gastrointestinal motility in adults. The aim of the study was to evaluate the MTS-1 for assessment of gastrointestinal transit times and motility patterns in healthy children.MethodsTwenty-one healthy children (nine girls), median age 10 (range 7–12) years were included. For evaluation with MTS-1, a small magnetic pill was ingested and tracked through the gastrointestinal tract by a matrix of 16 magnetic sensors placed behind a nonmagnetic bed. The children were investigated for 8 hours after swallowing the magnetic pill and again for 4 hours the following morning. After leaving the unit, each child came back after every bowel movement to determine if the pill had been expelled.ResultsNineteen children could swallow the pill. Characteristic contraction patterns were identified for the stomach (three per minute), small intestine (9–11 per minute), and colon (4–5 per minute). Median total gastrointestinal transit time was 37.7 (range 9.5–95.8) hours, median gastric emptying time was 37 (range 2–142) minutes, median small intestinal transit time was 302 (range 164 to >454) minutes, and median colorectal transit time was 38.1 (range 5.6–90.0) hours.ConclusionMTS-1 allows minimally invasive evaluation of gastrointestinal motility in children. Use of the method is, however, restricted by the nonambulatory setup.

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“…Different studies have revealed the prolonged small intestinal transit time in adult and pediatric CF patients with exocrine pancreatic insufficiency compared to healthy controls [77][78][79]. The prolonged small intestinal transit time was not corrected by PERT.…”

Section: Small Intestinal Transit Timementioning

confidence: 88%

Persistent Fat Malabsorption in Cystic Fibrosis

Bodewes

Wouthuyzen-Bakker

Verkade

2015

Diet and Exercise in Cystic Fibrosis

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Gastrointestinal transit times and motility in patients with cystic fibrosis

Abstract: In spite of normal contraction patterns, overall passage through the small intestine is significantly delayed in CF patients while upper small intestinal transit may be abnormally fast.

Cited by 47 publications

References 29 publications

Pilot study trialling a new ambulatory method for the clinical assessment of regional gastrointestinal transit using multiple electromagnetic capsules

Pilot study trialling a new ambulatory method for the clinical assessment of regional gastrointestinal transit using multiple electromagnetic capsules

Magnet tracking allows assessment of regional gastrointestinal transit times in children

Persistent Fat Malabsorption in Cystic Fibrosis

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