Gastroparesis in Systemic Lupus Erythematosus: A Case Report

Chou,

doi:10.4021/jmc1180w

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Systemic lupus erythematosus (SLE) is often listed as one of the rare causes of gastroparesis 4 . In SLE, gastrointestinal symptoms are varied and can involve any part of the GI tract; esophageal dysmotility and intestinal pseudo‐obstruction are often described.…”

Section: Discussionmentioning

confidence: 99%

“…Gastroparesis can be a feature of many AIRDs, particularly SSc‐spectrum diseases which most commonly include SSc and mixed connective tissue disease 3 . SLE and Sjogren are also among the rare causes of gastroparesis 4,5 . In SSc, gastrointestinal symptoms are varied and can involve any part of the GI tract, but esophageal dysmotility, intestinal pseudo‐obstruction, and constipation are most often described 6 …”

Section: Introductionmentioning

confidence: 99%

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Prevalence and clinical correlates of antinuclear antibody in patients with gastroparesis

Parkman

Natta

Makol

et al. 2021

Neurogastroenterology Motil

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Background Autoimmunity may play a role in the pathogenesis of gastroparesis in a subset of patients. Antinuclear antibody (ANA) testing is often used to screen for autoimmune disorders. Aims 1) Determine prevalence of a positive ANA in patients with gastroparesis; 2) Describe characteristics of idiopathic gastroparesis patients with positive ANA. Methods Patients were assessed with gastric emptying scintigraphy (GES), symptom assessment via Patient Assessment of Upper GI Symptoms [PAGI‐SYM], and blood tests—ANA, erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP). Results Positive ANA was seen in 148 of 893 (17%) patients with gastroparesis, being similar in idiopathic (16% of 536 patients), T1DM (16% of 162), T2DM (18% of 147), and postfundoplication (19% of 48 patients) gastroparesis. Among 536 patients with idiopathic gastroparesis, ANA titer 1:40–1:80 was seen in 33 (6%) patients, 1:160–1:320 in 36 (7%) patients, and ≥1:640 in 17 (3%) patients. Increasing ANA titer was associated with female gender (p = 0.05), Hispanic ethnicity (p = 0.02), comorbid rheumatoid arthritis (p = 0.02), systemic sclerosis (p = 0.004), and elevated ESR (p = 0.007). ANA positivity was associated with lower total GCSI (p = 0.007) and lower nausea/vomiting subscale (p = 0.0005), but not related to gastric emptying. Conclusions The prevalence of a positive ANA in patients with gastroparesis was high at ~17% and did not differ significantly based on etiology. In idiopathic patients, ANA positivity was associated with rheumatoid arthritis, systemic sclerosis, and elevated ESR. ANA‐positive gastroparesis represents a subset who often have other autoimmune symptoms or disorders, but less severe nausea and vomiting.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and clinical correlates of antinuclear antibody in patients with gastroparesis

Parkman

Natta

Makol

et al. 2021

Neurogastroenterology Motil

View full text Add to dashboard Cite

show abstract

“…Conversely, in gastroparesis patients who show an improvement with prokinetic medications, there was a decreased frequency of depression and anxiety [ 20 - 22 ]. As many as 18% and 31% of gastroparesis patients suffer from severe depression and severe anxiety, respectively, leaving a sizeable population with a limited prognosis [ 23 - 25 ]. Despite this strong evidence linking gastroparesis to depression and anxiety, there is currently not enough evidence that can help ascertain which interventions would be most helpful or how they would improve outcomes.…”

Section: Discussionmentioning

confidence: 99%

Gastroparesis in Non-Diabetics: Associated Conditions and Possible Risk Factors

Nassar

Richter

2018

Gastroenterol Res

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BackgroundGastroparesis is a syndrome characterized by delayed gastric emptying in the absence of any mechanical cause. While often associated with diabetes mellitus, most cases of gastroparesis are idiopathic. The purpose of the present paper is to review the co-morbid conditions that most likely associate with non-diabetic gastroparesis.MethodsThe Healthcare Cost and Utilization Project: Nationwide Inpatient Sample (HCUP-NIS) data were used from the year 2013 - 2014 and the Apriori algorithm was run on this subset of patients to identify what co-morbid conditions are most likely associated with gastroparesis.ResultsNotable conditions that were found to be most closely linked with gastroparesis were: chronic pancreatitis, end stage renal disease, irritable bowel syndrome, systemic lupus erythematosus, fibromyalgia, and venous thromboembolism. Some of the implications of these findings are briefly discussed.ConclusionsGastroparesis is strongly associated with multiple medical conditions which may be potential targets for treatment.

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Gastroparesis in Systemic Lupus Erythematosus: A Case Report

Cited by 2 publications

References 6 publications

Prevalence and clinical correlates of antinuclear antibody in patients with gastroparesis

Prevalence and clinical correlates of antinuclear antibody in patients with gastroparesis

Gastroparesis in Non-Diabetics: Associated Conditions and Possible Risk Factors

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