Gastropharyngeal and Gastroesophageal Reflux in Globus and Hoarseness

Smit, Conrad F.; Leeuwen, Justin A. M. J. van; Mathus-Vliegen, Lisbeth; Devriese, P. P.; Семин, А. В.; Tan, Joep; Schouwenburg, Paul F.

doi:10.1001/archotol.126.7.827

Cited by 61 publications

(45 citation statements)

References 19 publications

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“…7 The mechanisms proposed to explain laryngopharyngeal reflux and the resultant globus sensation include direct inflammation of the pharynx, referred discomfort from the esophagus due to reflux esophagitis, and reflex hypertonicity of the upper esophageal sphincter. 8 In addition, many other conditions that cause irritation and inflammation of the pharynx, such as tonsillitis or chronic sinusitis with postnasal drip, are considered to be related to globus sensation.…”

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confidence: 99%

Role of salivary function in patients with globus pharyngeus

et al. 2009

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Role of salivary function in patients with globus pharyngeus

et al. 2009

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“…Acute and brief exposure of the esophagus to acid reflux represents a physiologic sensory stimulus which in health produces increased peristalsis, swallowing, and salivation to both clear and neutralise acid, thus avoiding tissue damage [5][6][7]. Chronic acid reflux, however, is associated with impaired motor responses to esophageal acidification and with altered sensation (desensitization or hypersensitivity) [8][9][10][11][12][13][14]. It is not clear whether alterations in central motor neurophysiology occur that contribute to alterations in esophageal motor function after acid reflux.…”

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Modulation of Activity in Swallowing Motor Cortex Following Esophageal Acidification: A Functional Magnetic Resonance Imaging Study

et al. 2007

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Esophageal acid exposure induces sensory and motility changes in the upper gastrointestinal tract; however, the mechanisms involved and the effects on activity in the brain regions that control swallowing are unknown. The aim of this study was to examine functional changes in the cortical swallowing network as a result of esophageal acidification using functional magnetic resonance imaging (fMRI). Seven healthy volunteers (3 female, age range=20-30 years) were randomized to receive either a 0.1 M hydrochloric acid or (control) saline infusion for 30 min into the distal esophagus. Postinfusion, subjects underwent four 8 min blocks of fMRI over 1 h. These alternated between 1 min swallowing water boluses and 1 min rest. Three-dimensional cluster analysis for group brain activation during swallowing was performed together with repeated-measures ANOVA for differences between acid and saline. After acid infusion, swallowing-induced activation was seen predominantly in postcentral gyrus (p<0.004). ANOVA comparison of acid with saline showed a significant relative reduction in activation during swallowing of the precentral gyrus (M1) BA 4 (p<0.008) in response to acid infusion. No areas of increased cortical activation were identified with acid vs. saline during swallowing. Esophageal acidification inhibits motor and association cortical areas during a swallowing task, probably via changes in vagal afferent or nociceptive input from the esophagus. This mechanism may play a protective role, facilitating acid clearance by reduced descending central motor inhibition of enteric/spinal reflexes, or by preventing further ingestion of injurious agents.

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“…4 The chronic onset is mainly caused by vocal cord nodule, polyp, laryngeal papillomatosis, tumor of vocal cord, functional dysphonia, smoking, vocal abuse, laryngopharyngeal reflux disease, post nasal drip, vocal abuse, neo plasm of thyroid, oesophagus, lung, chronic granulomatous disease like tuberculosis or systemic disease like diabetes mellitus. [5][6][7] The complaints of hoarseness of long duration may imply serious disease, so it should not be ignored. …”

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Clinicopathological Profile Study of Hoarseness of Voice

Hongal¹

2018

jebmh

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BACKGROUNDHoarseness of voice may be present due to various underlying pathologies. Hoarseness is subjective term used to describe abnormal voice quality which may occur due to many causes because it is just a symptom. Proper knowledge and clinic pathological profile is important to treat the underlying pathology. The aim and objectives of this study were 1. To study incidence, duration and sex predilection for hoarseness of voice. 2. To study different etiological and predisposing factors for hoarseness of voice. 3. Comparison of various methods in the early etiological diagnosis. 4. Study the various pathological correlates in various conditions causing hoarseness. 5. Relation of hoarseness with respect to various occupations.

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Gastropharyngeal and Gastroesophageal Reflux in Globus and Hoarseness

Abstract: We found a high prevalence of pathologic reflux in patients with both globus and hoarseness. Based on these findings, we strongly advise upper gastrointestinal endoscopy for symptomatic otolaryngological patients with pathologic gastroesophageal reflux.

Cited by 61 publications

References 19 publications

Role of salivary function in patients with globus pharyngeus

Role of salivary function in patients with globus pharyngeus

Modulation of Activity in Swallowing Motor Cortex Following Esophageal Acidification: A Functional Magnetic Resonance Imaging Study

Clinicopathological Profile Study of Hoarseness of Voice

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