Gastroprotective action of the extract of Corydalis yanhusuo in Helicobacter pylori infection and its bioactive component, dehydrocorydaline

Wu, Hao; Sun, Qingyue; Dong, Huirong; Qiao, Jiasen; Lin, Ying; Chen, Yu; Li, Yanni

doi:10.1016/j.jep.2023.116173

Cited by 7 publications

(4 citation statements)

References 48 publications

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Section: Resultsmentioning

confidence: 99%

“…Autoimmunity is triggered by elevated levels of IgG antibodies resulting from the H. pylori infection, subsequently giving rise to the emergence of inflammatory disorders. 33 Additionally, the pathogenicity of H. pylori infection is significantly impacted by its virulence factors. 34 Ulasoglu et al 35 have reported that CagA-IgG is primarily linked to inflammation rather than atrophy.…”

Section: Ila Decreases the Elevated Igg Antibody Levels Caused By H P...mentioning

confidence: 99%

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Indole-3-Lactic Acid Derived from Lacticaseibacillus paracasei Inhibits Helicobacter pylori Infection via Destruction of Bacteria Cells, Protection of Gastric Mucosa Epithelial Cells, and Alleviation of Inflammation

Yao,

Cao,

Zhang

et al. 2024

J. Agric. Food Chem.

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Indole-3-lactic acid (ILA) has exhibited antimicrobial properties. However, its role in inhibiting Helicobacter pylori infection remains elusive. This study investigated the inhibitory effect of ILA produced by Lacticaseibacillus paracasei on H. pylori, which was further confirmed by cell and animal experiments. 5 mg/mL ILA was sufficient to directly inhibit the growth of H. pylori in vitro, with a urease inhibitory activity reaching 60.94 ± 1.03%, and the cell morphology and structure were destroyed. ILA inhibited 56.5% adhesion of H. pylori to GES-1 and significantly reduced the number of apoptotic cells. Furthermore, ILA suppresses H. pylori colonization by approximately 38% to 63%, reduced inflammation and oxidative stress in H. pylori-infected mice, and enhanced the enrichment and variety of gut microbiota, notably fostering the growth of beneficial bacteria such as Lactobacillus and Bif idobacterium strains. The results support that ILA derived from Lactobacillus can be applicated as a novel prebiotic in anti-H. pylori functional foods.

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Section: Resultsmentioning

confidence: 99%

Section: Ila Decreases the Elevated Igg Antibody Levels Caused By H P...mentioning

confidence: 99%

Indole-3-Lactic Acid Derived from Lacticaseibacillus paracasei Inhibits Helicobacter pylori Infection via Destruction of Bacteria Cells, Protection of Gastric Mucosa Epithelial Cells, and Alleviation of Inflammation

Yao,

Cao,

Zhang

et al. 2024

J. Agric. Food Chem.

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“…In the same test, the potential of thiourea was tested for whom the calculated IC 50 value was 92.7 mg/L. Previously, berberine was recognized as a compound with activity against Helicobacter pylori [40]. Evidence from a clinical trial suggests that berberine combined with standard therapy can be an option to eradicate H. pylori [41,42].…”

Section: Helicobacter Pylori and Urease Inhibitionmentioning

confidence: 99%

Optimized Centrifugal Partition Chromatography (CPC) Protocol for Isolation of Urease Inhibitors: Magnoflorine and Berberine from Berberis vulgaris Extracts

Nakonieczna,

Susniak,

Bozhadze

et al. 2024

Separations

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In recent years, an increasing interest in phytotherapy has been observed. Parallel to the research on the total extracts of plant material, numerous studies on the activity of single molecules derived from plants are being conducted to address their mechanisms of action and determine active doses and eventual interactions. Despite this phenomenon, the isolation of individual compounds is a bottleneck due to its difficulty and cost. This work presents the results of a careful optimization of magnoflorine and berberine (isoquinoline alkaloids) recovery from a commonly distributed shrub, Berberis vulgaris, growing in Poland and Georgia, using CPC. Both compounds are known for their numerous medicinal properties, which makes the isolation methodology an important area of research. Additionally, CPC has the ability to isolate high-quality compounds in large quantities, which makes it an effective and easy-to-commercialize method. For a successful separation, the biphasic solvent system composed of hexane, butanol, ethanol, and water in a ratio (3:12:4:16 v/v/v/v) was used in the ascending mode, together with the flow rate of 8 mL/min and rotation speed of 1600 rpm. The method was selective for both compounds, and it delivered good results for both root and stem extracts from the plant. The qualitative composition of alkaloids in the studied extracts determined by HPLC-ESI-QTOF-MS/MS confirmed the presence of berberine, magnoflorine, jatrorhizine, and palmatine alkaloids from the group of isoquinolines. The isolates, magnoflorine and berberine, were subjected to the Helicobacter pylori growth inhibition assay and urease inhibition test to assess whether, next to the previously proved anticancer properties, these compounds are characterized by H. pylori inhibition. MGN was found to exhibit inhibitory potential against urease (IC50 = 25 mg/L).

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“…Several investigations into the mechanisms of anti-H. pylori capacities have shown that polyphenols may lead to a decrease in urease activity, inhibition of cytotoxic activity as well as its binding with the gastric mucosa, and the rupture of outer membrane (Burger et al, 2002;Lin et al, 2005;Yahiro et al, 2005;Nohynek et al, 2006). According to a previous study, polyphenols as an adjuvant in the treatment of H. pylori infection can significantly improve the eradication rate (Wang et al, 2023;Wu et al, 2023), while no evidence has been found to suggest an increased risk of side effects. Consequently, polyphenols are suggested as an alternative treatment approach for H. pylori infection.…”

Section: Polyphenolsmentioning

confidence: 99%

The effects and mechanisms of natural products on Helicobacter pylori eradication

Deng,

Chen,

Zhao

et al. 2024

Front. Cell. Infect. Microbiol.

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Helicobacter pylori (H. pylori) eradication is pivotal for alleviating gastric mucosal inflammation and preventing the progression of gastric diseases. While antibiotic-based therapies have achieved significant success in H. pylori eradication, challenges such as antibiotic resistance, drug toxicity, side effects, nonadherence, inapplicability, and disruption of gastrointestinal microflora have emerged. Updated therapies are urgently needed to suppress H. pylori. Nature has provided multitudinous therapeutic agents since ancient times. Natural products can be a potential therapy endowed with H. pylori eradication efficacy. We summarize the basic information, possible mechanisms, and the latest research progress of some representative natural products in H. pylori eradication, highlighting their safety, accessibility, efficiency, and ability to overcome limitations associated with antibiotic application. This review highlights the potential therapeutic advantages of incorporating ethnomedicine into anti-H. pylori regimens. The findings of this review may provide insights into the development of novel natural products and expand the therapeutic options available for H. pylori eradication.

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Gastroprotective action of the extract of Corydalis yanhusuo in Helicobacter pylori infection and its bioactive component, dehydrocorydaline

Cited by 7 publications

References 48 publications

Indole-3-Lactic Acid Derived from Lacticaseibacillus paracasei Inhibits Helicobacter pylori Infection via Destruction of Bacteria Cells, Protection of Gastric Mucosa Epithelial Cells, and Alleviation of Inflammation

Indole-3-Lactic Acid Derived from Lacticaseibacillus paracasei Inhibits Helicobacter pylori Infection via Destruction of Bacteria Cells, Protection of Gastric Mucosa Epithelial Cells, and Alleviation of Inflammation

Optimized Centrifugal Partition Chromatography (CPC) Protocol for Isolation of Urease Inhibitors: Magnoflorine and Berberine from Berberis vulgaris Extracts

The effects and mechanisms of natural products on Helicobacter pylori eradication

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