Gastroprotective Activities of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the Growth of the Stomach Cancer AGS Cell Line and Indomethacin-Induced Gastric Ulcers

Abstract

Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seeds have long been used to treat warts, chapped skin, rheumatism, and neuralgia in traditional Chinese medicine (TCM). Recently, studies demonstrated its anti-inflammatory, antiproliferative, antitumor, and antiallergic activities. In the present study, we first report the gastroprotective effects of dehulled adlay (DA) seeds, which consist of bran (AB) and endosperm (AE). The DA ethanolic extract (DAE) was prepared, along with the AB and AE ethanolic extracts (ABE and AEE), and the inhibitory effects of these extracts were tested on the AGS gastric cancer cell line. Results indicated that the ABE showed better antiproliferative activity, and 19 compounds were purified from AB in a further phenolic-compound-guided separation. Among the isolated compounds, caffeic and chlorogenic acids significantly suppressed the growth of AGS cells. In addition, the antiulcer activity of DA was examined in an indomethacin-induced gastric lesion model. The ulcer index (UI) and oxidative biomarkers in animals decreased, while the non-protein sulfhydryl (NPSH) groups were elevated when given DA. This is the first investigation of antiulcer activity of adlay, and we demonstrated that the antioxidative-active phenolic acids in DA contribute to some portion of the gastroprotective effects.

Phytochemical screening, antibacterial and anthelmintic activities of leaf and seed extracts of Coix lacryma-jobi L.

“…Job's tears are taken by people due to its beneficial effect for hay fever, high cholesterol, cancer, warts, obesity, arthritis, allergic disorder and respiratory tract infections. Many scholars have reported different biological activities of Job's tears, including antioxidant/free radical scavenging [12], anti-inflammatory [13,14], anti-tumor [12,15,16], hypolipidemic [17], hypocholesterolemic [18], anti-allergic [19,20], hypoglycemic [21], antiobesity [22], anti-mutagenic [23], anti-ulcer [24], prebiotic activity [25], hormonal modulation [26], osteoporosis preventing [27], abortifacient [28] and antimicrobial effect [29].…”

Coix lacryma‐jobi associated symmetrical drug‐related intertriginous and flexural exanthema

“…1 Cutaneous vasculitis induced by HZ is a rare event and may appear at the site of previous and healed HZ eruption, 2 which is an example of Wolf's isotopic response. 3,4 However, the case reported by Wollina and Sch€ onlebe is different and, to the best of our knowledge, unique in that the HZ-related disorder (vasculitis) preceded the outbreak of herpetic lesions in the same dermatome. Interestingly, vasculitis was mainly located on the distal segment, while HZ appeared on the proximal segment of the dermatome.…”

“…Coix lacrymajobia major component of Ibane â , known colloquially as Job's tears, coixseed, or adlaihas long been used in Nowadays, many studies have demonstrated that Coix lacryma-jobi has anti-inflammatory, antiproliferative, antitumor, and antiallergic activities. [3][4][5] Currently, Coix lacryma-jobi is approved by the Korean Food and Drug Administration based on the theoretical backgrounds of Korean traditional herbal medication, and today it is widely used in over-the-counter settings throughout Korea. Nitric oxide or superoxide overproduction by activated macrophages is believed to be critically involved in both acute and chronic inflammation.…”

Integrative Medicine for Relief of Nausea and Vomiting in the Treatment of Colorectal Cancer Using Oxaliplatin‐Based Chemotherapy: A Systematic Review and Meta‐Analysis

“…Coix extract was found to produce dose‐dependent gastroprotection against indomethacin. This effect was at least partially because of antioxidant actions of the phenolic acids in Coix (Chung et al, ). A methanol extract of Coix seeds was found to reduce nitric oxide and superoxide production in RAW 264.7 macrophages (Seo et al, ).…”