Gastroprotective activities of Peperomia pellucida L. and Pachyrhizus erosus L. extracts combination on ethanol-induced rats

Abstract

Gastroprotective is an effect caused by the compounds that have the capability of protecting the gastric mucosa. Peperomia pellucida plants contain alkaloids, avonoids, saponins, tannins, and terpenoids, while Pachyrhizus erosus contains avonoids, alkaloids, tannins, and saponins. Peperomia pellucida reportedly contains dillapiole compounds with a gastroprotective effect. Moreover, its isolation result from Pachyrhizus erosus indicates the presence of dulcitol, gentisic acid, and formononetin, which has antioxidant activity. This study aims to determine the gastroprotective effect of the combination of Peperomia pellucida and Pachyrhizus erosus extract on rats with gastric ulcer models by looking at the ulcer index, percentage of inhibition, and histopathology. The research method used in this study was by making a combination of Peperomia pellucida and Pachyrhizus erosus extract. The combined extract was then given to 5 treatment groups. Group I as a negative control, group II as a positive control was given sucralfate, groups III, IV, and V were given a combination of Peperomia pellucida and Pachyrhizus erosus extract of 100, 200, and 400 mg/kg BW. The treatment was given orally for 14 days, after one hour of treatment on the 14th day, 96% ethanol induction was given orally at a dose of 5 mg/kg BW. The animal dissection was performed 24 hours after the induction. The results from observations showed an increase in body weight before and after the treatment. The ulcer index produced by negative control, positive control in the treatment with doses of 100, 200, and 400 were 4.18; 2.98; 2.42; 2.04; and 1.07. This study showed that the combination of Peperomia pellucida and Pachyrhizus erosus extract has a gastroprotective effect.

Supplementation of yam bean (Pachyrhizus erosus L.) fiber ameliorates dyslipidemia, liver pathology and hypersecretion of metabolic hormones in mice fed a highfat diet

“…Yam bean tuber (Pachyrhizus erosus L., Leguminosae) is commonly consumed in Latin America, Asia, and Africa as fresh or processed food. The yam bean tuber highly contains various compounds (1), which have been demonstrated to offer numerous health benefits, including antidiabetic (2), cardioprotective (3), antioxidant (4), and gastroprotective properties (5). Every 100 g of fresh yam bean tuber contains approximately 1.4-6% of dietary fiber (1).…”