Gastroprotective Activity of Melatonin and Its Precursor, L-Tryptophan, against Stress-induced and Ischaemia-induced Lesions Is Mediated by Scavenge of Oxygen Radicals

Pc, Konturek; Sj, Konturek; Brzozowski, T; Dembiński, Artur; Zembala, Marek; Mytar, B; Eg, Hahn

doi:10.3109/00365529709025077

Cited by 57 publications

(50 citation statements)

References 21 publications

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“…It has been observed that during an I/R syndrome the temporary deficit in oxygen alters the oxidative cellular metabolism [27]. Early work from our group and others showed that melatonin had a remarkable effect in protecting gastric mucosa from the acute damage induced by different procedures [3][4][5][6][7][8][9][10][11][12][13], including I/R [2,12,14]. The results of many of these experiments demonstrated that the free radical scavenger properties of melatonin and the increase in anti-oxidative enzymes significantly contribute to the protection by that hormone against gastric injury.…”

Section: Discussionmentioning

confidence: 99%

“…Results were expressed as pmol/min/mg protein. 2 Determination of Prostaglandins. In rats sacrificed 90 min after melatonin administration, gastric tissue samples were processed for prostanoids using the method described previously [26].…”

Section: Analytical Procedures With Relation To Nomentioning

confidence: 99%

“…Recently in vivo and in vitro studies have shown important beneficial actions of melatonin in various models of gastrointestinal damage, such as stress [2][3][4][5], alcohol [6,7], non-steroidal anti-inflammatory drug (NSAID) administration [8,9] or ischemia-reperfusion (I/R)-induced injuries [2,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Melatonin Modulates the Effects of Gastric Injury in Rats: Role of Prostaglandins and Nitric Oxide

Deogracias¹,

Alarcón‐de‐la‐Lastra²,

Jimenez³

et al. 2003

Neurosignals

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Experimental evidence has been presented connecting melatonin with the prevention or treatment of gastrointestinal disorders either by the scavenging properties of active oxygen or by receptor-mediated stimulation of gene expression of neutralizing enzymes. Prostaglandins and nitric oxide are important neuroimmunomodulators in digestive physiology and different studies have indicated that the protective properties of melatonin may be explained by prostaglandin and/or nitric oxide mechanisms. The aim of the present study was to examine the effect of intraperitoneal administration of melatonin on in vivo changes in PGE₂, generated in gastric mucosal lesions by ischemia-reperfusion. Cyclic GMP nucleotide was also studied as an index of the principal enzymatic activity involved in the metabolism of nitric oxide, the nitric oxide synthase. The different immunological tests showed that the intraperitoneal administration of melatonin prevents the postischemic decrease in prostaglandins. The concentration of this eicosanoid in the rat mucosa treated with 20 mg·kg^–1 of melatonin was significantly higher (p < 0.05) than that in the control rats. The amount of cyclic GMP in the stomach decreased because of ischemia-reperfusion. In treated animals however, a marked increase occurred in concentrations of GMP, but the difference was not statistically significant. The results suggest that the mechanism of protection afforded by melatonin against lesions induced by gastric ischemia-reperfusion may be due to stimulation of the synthesis of eicosanoid protectors during the ischemic process.

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Section: Discussionmentioning

confidence: 99%

Section: Analytical Procedures With Relation To Nomentioning

confidence: 99%

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Melatonin Modulates the Effects of Gastric Injury in Rats: Role of Prostaglandins and Nitric Oxide

Deogracias¹,

Alarcón‐de‐la‐Lastra²,

Jimenez³

et al. 2003

Neurosignals

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“…The liver and the gallblad-der are especially exposed to high levels of the hormone, because hepatic metabolism is the major pathway for deactivation of melatonin (Lane and Moss, 1985), which is also present in active form in bile and concentrated in the gallbladder (Tan et al, 1999). In the gastrointestinal tract, melatonin has a gastroprotective function (Konturek et al, 1997) and therapeutic effects against malignancy associated with irritable bowel syndrome (Head and Jurenka, 2003).…”

mentioning

confidence: 99%

Effects of Melatonin on Gallbladder Neuromuscular Function in Acute Cholecystitis

Gomez‐Pinilla¹,

Camello²,

Pozo³

2007

J Pharmacol Exp Ther

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“…The data in Table 4, showing that melatonin treatment reduced ulcer score and prevalence, suggest that a cause and effect relationship may exist. Recent reports support a gastroprotective effect for melatonin (Konturek et al 1997). …”

Section: Resultsmentioning

confidence: 99%

Effect of feed particle size and dietary melatonin supplementation on gastric ulcers in swine

Ayles¹,

Friendship²,

Bubenik³

et al. 1999

Can. J. Anim. Sci.

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. Effect of feed particle size and dietary melatonin supplementation on gastric ulcers in swine. Can. J. Anim. Sci. 79: 179-185. Gastric ulcers may be an underrecognized problem in the swine industry. An experiment was conducted to evaluate the effects of dietary melatonin supplementation and particle size on prevalence and severity of ulcers in growing pigs. Sixty-four Yorkshire barrows and gilts (29.5 ± 1.0 kg) received either a finely ground (763 ± 2.18 µm) or a coarsely ground (953 ± 2.29 µm) corn-wheat diet, either with or without added melatonin (5 mg kg -1 ). One half of the pigs underwent endoscopic examination to assess the severity of ulcers on days 4 and 25. Growth performance and feed consumption were monitored throughout the experiment. All pigs were slaughtered on day 28, and ulcers were assessed postmortem. Endoscopy at the beginning of the experiment found that 53% of the pigs already had some degree of ulceration. Pigs fed the fine diet had greater average daily gain and average daily feed intake than pigs fed the coarse diet (P < 0.05), but particle size did not significantly affect prevalence of stomach ulcers. Melatonin supplementation increased the apparent digestibility of crude protein (P < 0.04) and dry matter (P < 0.08) of the diets and decreased the prevalence of ulcers (P < 0.05) but did not significantly affect growth performance. Pigs that received melatonin had higher levels of melatonin (P < 0.01) in most gastrointestinal tissues, with highest concentrations found in the stomach (P < 0.001). Pigs that did not have ulcers had a higher concentration of melatonin in the plasma and stomach than pigs with ulcers (P < 0.05). Melatonin may be useful in decreasing ulcers. Initial ulcer condition may be a significant source of variation in growth experiments.Key words: Pigs, gastric ulcers, particle size, melatonin, gastrointestinal tract Ayles, H. L., Friendship, R. M., Bubenik, G. A. et Ball, R. O. 1999. Effet de la granulométrie des particules alimentaires et d'un complément de mélatonine sur l'apparition des ulcères gastriques chez les porcs. Can. J. Anim. Sci. 79: 179-185. Les ulcères gastriques pourraient bien être un problème trop peu connu dans le secteur porcin. Nous avons réalisé une expérience pour évaluer les effets d'un complément de mélatonine dans l'alimentation et du calibre des particules alimentaires sur la fréquence et sur la gravité des ulcères chez les porcs en croissance. Soixante-quatre porcs Yorkshire, castrats et cochettes, d'un poids moyen de 29,5 kg (± 1,0 kg) ont reçu un aliment maïs-blé, moulu fin (763 ± 2,18 µm) ou gros (953 ± 2,29 µm) et complété ou non de mélatonine à la dose de 5 mg kg -1 . La moitié des animaux subissaient un examen endoscopique pour évaluer la gravité des ulcères au jour 4 et au jour 25 de l'expérience. Les performances de croissance et la consommation alimentaire étaient surveillées en permanence. Tous les porcs étaient abattus au jour 28, après quoi on évaluait la gravité des ulcères. L'endoscopie faite au début de l'expérience a révélé ...

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Gastroprotective Activity of Melatonin and Its Precursor, L-Tryptophan, against Stress-induced and Ischaemia-induced Lesions Is Mediated by Scavenge of Oxygen Radicals

Abstract: Melatonin and L-tryptophan protect the gastric mucosa from damage by stress and ischaemia reperfusion, and this action is mediated, at least in part, by the limitation in the free radicals, the stimulation of mucosal generation of PG and by the increase in gastric blood flow.

Cited by 57 publications

References 21 publications

Melatonin Modulates the Effects of Gastric Injury in Rats: Role of Prostaglandins and Nitric Oxide

Melatonin Modulates the Effects of Gastric Injury in Rats: Role of Prostaglandins and Nitric Oxide

Effects of Melatonin on Gallbladder Neuromuscular Function in Acute Cholecystitis

Effect of feed particle size and dietary melatonin supplementation on gastric ulcers in swine

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