Gastroprotective and Anti-oxidative Properties of Ascorbic Acid on Indomethacin-induced Gastric Injuries in Rats

Koç, Murat; İmik, Halit; Odabaşoğlu, Fehmi

doi:10.1007/s12011-008-8205-9

Cited by 41 publications

(33 citation statements)

References 48 publications

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“…Conversely, increased activities of GSH peroxidase and GSH transferase, the enzyme responsible for the conjugation of toxic compounds with GSH, lead to decreased GSH concentration. This is in accordance with the observed decrease of GSH peroxidase and GSH transferase in indomethacin-induced gastric ulcer (Koc et al, 2008), ethanol-induced mucosal injury (Rao et al, 2004), and in stress ulcer (Liu et al, 2011) which may give additional support to our results.…”

Section: Discussionsupporting

confidence: 93%

Protective and Therapeutic Effects of Argyreia speciosa against Ethanol-Induced Gastric Ulcer in Rats

Motawi

Hamed

Hashem

et al. 2012

Zeitschrift Für Naturforschung C

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The protective and therapeutic effects of Argyreia speciosa Sweet (Convolvulaceae) against ethanol-induced gastric ulcer in rats were evaluated. Ethanolic and water extracts of the aerial plant parts (200 mg/kg body weight) were orally administered daily for seven days prior to or after ulceration with one oral dose of 1 mL absolute ethanol on 24-h empty stomachs. Rats were divided into eleven groups. Group 1 served as control. To groups 2 and 3 each extract was administered. Groups 4 to 6 received each extract or ranitidine (100 mg/ kg body weight) prior to ulcer induction. Groups 7 to 9 received each extract or ranitidine post ulcer induction. Groups 10 and 11 were gastric ulcerative rats after one hour and one week of ethanol induction. The evaluation was done through measuring ulcer indices: stomach acidity and volume, lesion counts, mucus, and prostaglandin E 2 contents. Oxidative stress marker, i. e. malondialdehyde, glutathione, and superoxide dismutase, were estimated. Certain marker enzymes for different cell organelles, i. e. succinate and lactate dehydrogenases, glucose-6-phosphatase, acid phosphatase, and 5'-nucleotidase, were evaluated. The work was extended to determine the collagen content and the histopathological assessment of the stomach. Gastric ulcer exhibited a signifi cant elevation of the ulcer index, antioxidant levels, collagen content, and the marker enzymes. The water extract attenuated these increments and was more potent as a protective agent, while the ethanol extract exhibited stronger therapeutic potency. In conclusion, A. speciosa acted as antiulcer agent. More detailed studies are required to identify the compounds responsible for the pharmacological effect.

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Section: Discussionsupporting

confidence: 93%

Protective and Therapeutic Effects of Argyreia speciosa against Ethanol-Induced Gastric Ulcer in Rats

Motawi

Hamed

Hashem

et al. 2012

Zeitschrift Für Naturforschung C

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“…Antioxidants have been shown to inactivate reactive oxygen species (ROS) and thus protect cells from oxidative damage (11). Lower plasma levels of antioxidant substances such as vitamin C, E and lipoic acid cause increased oxygen free radicals in stressed poultry.…”

Section: Discussionmentioning

confidence: 99%

“…Ascorbic acid (AA) (11) and α-lipoic acid (ALA) (5) are primary antioxidants in biological systems and are capable of breaking the chain of lipid peroxidation in cell membranes.…”

Section: Introductionmentioning

confidence: 99%

Effects of ascorbic and α-lipoic acid on secretion of HSP- 70 and apoptosis in liver and kidneys of broilers exposed to heat stress

Kapakin¹,

Kübra²,

Recep³

et al. 2012

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:The objective of this experiment was to evaluate the ameliorative effect of L-ascorbic acid (AA) and α-lipoic acid (ALA) on tissue damage caused by heat stress (HS) in the liver and kidneys of broilers, and to correlate this effect with the secretion of the heat shock protein-70 (HSP-70) protein and apoptosis. The study broilers of breed Ross 308 were used. Animals included in the control were divided into four groups. Group TN; control thermoneutral broilers (24 0 C) were not administered with antioxidants in the diet and not subjected to heat stress (TN). Group HS; broilers not administered with antioxidants in the diet but subjected to heat stress (34 0 C) (HS). Group HS+AA; broilers subjected to heat stress (34 0 C) and administered with ascorbic acide (AA).HS+ALA; broilers subjected to heat stress (34 0 C) and administered with α-lipoic acid (AAA). Then, all of the groups were sacrificed and organs (liver and kidney) were collected for histopathological and immunohistochemstry evaluations. Histopathological examination demonstrated that, in the liver and kidneys in Group HS, the blood vessels were very hyperemic. Hepatocytes as well as in tubulo epithelial cells of kidney displayed degenerative alterations. Lesions similar to those observed in Group HS were also observed in Groups HS+AA and HS+ALA. However, the liver and kidney HSP-70 secration were greater in Groups HS+AA, HS+ALA and TN than in Groups HS. The greatest number of apoptotic cells was determined in Group HS, whilst the lowest numbers were determined in Groups TN and HS+ALA. Dietary supplementation with ALA was more effective than AA at preventing tissue damage. Key words: Ascorbic acid, α-lipoic acid, apoptosis, broiler, heat shock proteins, heat stress. Anahtar sözcükler: Askorbik asit, α-lipoik asit, apoptozis, broiler, ısı şok proteini, sıcaklık stresi. Sıcaklık

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“…These include several versions of aspartate aminotransferase (PDB 1AKB, 1AMA, 1CQ7, 1CQ8, 1MAQ), acetylcholinesterase (PDB 1E66), serum albumin (PDB 1HK1), peroxisome proliferator-activated receptor alpha (PDB 1KKQ), heat shock protein 90 (PDB 1UY9, 1UYD) thymidylate synthase (PDB 1ZPR), glutathione S-transferase (PDB 1YDK), and dihydrofolate reductase (PDB 1CD2). For example, indomethacin has been shown to diminish acetylcholinesterase activity in rats while altering intestine contractions [43], significantly decrease glutathione S-transferase [44], act as a competitive inhibitor of dihydrofolate reductase [45], alter thymidine kinase activity in rats during liver regeneration [46], act as an agonist for peroxisome proliferator-activated receptors alpha [47] and belong in a cluster of other NSAIDs [48]. …”

Section: Resultsmentioning

confidence: 99%

Mammary carcinogen-protein binding potentials: novel and biologically relevant structure–activity relationship model descriptors

Cunningham

Qamar

Carrasquer

et al. 2010

SAR and QSAR in Environmental Research

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Previously, SAR models for carcinogenesis used descriptors that are essentially chemical descriptors. Herein we report the development of models with the cat-SAR expert system using biological descriptors (i.e., ligand-receptor interactions) rat mammary carcinogens. These new descriptors are derived from the virtual screening for ligand-receptor interactions of carcinogens, non-carcinogens, and mammary carcinogens to a set of 5494 target proteins. Leave-one-out validations of the ligand mammary carcinogen non-carcinogen model had a concordance between experimental and predicted results of 71% and the mammary carcinogen non-mammary carcinogen model was 72% concordant. The development of a hybrid fragment-ligand model improved the concordances to 85 and 83%, respectively. In a separate external validation exercise, hybrid fragment-ligand models had concordances of 81 and 76%. Analyses of example rat mammary carcinogens including the food mutagen and estrogenic compound PhIP, the herbicide atrazine, and the drug indomethacin, the ligand model identified a number of proteins associated with each compound that had previously been referenced in Medline in conjunction with the test chemical and separately with association to breast cancer. This new modelling approach can enhance model predictivity and help bridge the gap between chemical structure and carcinogenic activity by descriptors that are related to biological targets.

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Gastroprotective and Anti-oxidative Properties of Ascorbic Acid on Indomethacin-induced Gastric Injuries in Rats

Cited by 41 publications

References 48 publications

Protective and Therapeutic Effects of Argyreia speciosa against Ethanol-Induced Gastric Ulcer in Rats

Protective and Therapeutic Effects of Argyreia speciosa against Ethanol-Induced Gastric Ulcer in Rats

Effects of ascorbic and α-lipoic acid on secretion of HSP- 70 and apoptosis in liver and kidneys of broilers exposed to heat stress

Mammary carcinogen-protein binding potentials: novel and biologically relevant structure–activity relationship model descriptors

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