Gastroprotective effect of adrenomedullin administered subcutaneously in the rat

Clementi, Giuseppe; Caruso, A.; Cutuli, V. M. C.; Mangano, Nunzio Guido; Salomone, Salvatore; Lempereur, Laurence; Prato, A.; Matera, M; Amico‐Roxas, M.

doi:10.1016/s0196-9781(02)00048-7

Cited by 26 publications

(15 citation statements)

References 22 publications

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“…Bell-shaped dose-reponse relationship was observed for example with RX 77368 (a stable TRH analog) [28], adrenomedullin [29], nociceptin and nocistatin [25], substance P [10] and angiotensin II [15]. In most cases the gastroprotective ranges varied between 10-fold and 100-fold, which is in agreement with the biphasic responses observed in other fields.…”

Section: Dose-reponse Relationshipssupporting

confidence: 79%

Brain neuropeptides in gastric mucosal protection

Gyires

Zádori

2014

Current Opinion in Pharmacology

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The centrally induced gastroprotective effect of neuropeptides has been intensively studied. Besides many similarities, however, differences can also be observed in their gastroprotective actions. The gastroprotective dose-response curve proved to be either sigmoid, or bell-shaped. Additional gastrointestinal effects of neuropeptides can contribute to their mucosal protective effect. Part of the neuropeptides induce gastroprotection by peripheral administration as well. Besides vagal nerve the sympathetic nervous system may also be involved in conveying the central effect to the periphery. Better understanding of the complex mechanism of the maintenance of gastric mucosal integrity may result in the development of new strategy to enhance gastric mucosal resistance against injury. AbstractThe centrally induced gastroprotective effect of neuropeptides has been intensively studied.Besides many similarities, however, differences can also be observed in their gastroprotective actions. The gastroprotective dose-response curve proved to be either sigmoid, or bell-shaped.Additional gastrointestinal effects of neuropeptides can contribute to their mucosal protective effect. Part of the neuropeptides induce gastroprotection by peripheral administration as well.Besides vagal nerve the sympathetic nervous system may also be involved in conveying the central effect to the periphery. Better understanding of the complex mechanism of the maintenance of gastric mucosal integrity may result in the development of new strategy to enhance gastric mucosal resistance against injury.

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Section: Dose-reponse Relationshipssupporting

confidence: 79%

Brain neuropeptides in gastric mucosal protection

Gyires

Zádori

2014

Current Opinion in Pharmacology

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“…Taken together, all these data suggest that AM acts via intramural fundic neurons stimulating somatostatin and, thus, inhibiting histamine and acid secretion in the stomach. But AM not only decreases acid output it also reduces total gastric juice volume by 38% and raises pH values [151].…”

Section: Physiological Roles Of Am In the Stomachmentioning

confidence: 94%

“…Trying to explain the conflicting results reported about the effect of peripheral or central administration of AM in gastric emptying [159,160], Clementi et al [151] tried to verify the activity of AM administered subcutaneously in a single dose on gastric ulceration induced by 3 different methods. Subcutaneous injections of AM prevent reserpine-induced gastric mucosal damage in a dosedependent manner and reduce ulcer formation in pylorus-ligated rats, but do not interfere with the lesions produced by ethanol administration.…”

Section: Gastroprotective Effect Of Ammentioning

confidence: 99%

“…Subcutaneous injections of AM prevent reserpine-induced gastric mucosal damage in a dosedependent manner and reduce ulcer formation in pylorus-ligated rats, but do not interfere with the lesions produced by ethanol administration. In both gastric lesions induced by reserpine and by pylorus ligation, the gastroprotective action of AM is associated with a decrease of acidity and volume of gastric secretion, whereas the ulcers induced by ethanol are acid independent [151]. Because there is an evident correlation between gastric pH and incidence of gastric damage, it appears plausible that peripherally administered AM exerts a gastroprotective effect, at least in part, through its antisecretory activity that involves gastric somatostatin [156].…”

Section: Gastroprotective Effect Of Ammentioning

confidence: 99%

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Adrenomedullin regulates intestinal physiology and pathophysiology

Martínez-Herrero

Martı́nez

2016

Domestic Animal Endocrinology

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“…In addition, some evidence shows that otective effect on acetic acid-6 , induced gastric lesions models 13 . In the present study, we demonstrated that AM can also elicit a two alternative models.…”

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confidence: 99%

Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease

Nagata¹

2015

AJLS

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Adrenomedullin (AM) is a novel hypotensive peptide that also exerts powerful anti-inflammatory effects. We recently showed that AM significantly reduces the clinical severity of acetic acid-induced colitis, an experimental model of inflammatory bowel disease (IBD) in rats. In the present study, we examined the effect of AM in two alternative rat models of IBD. We found that 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced megacolon development in the saline-treated group, but AM treatment reduced the macroscopic damage caused by TNBS. In the dextran sulfate sodium (DSS) model, treatment with AM reduced diarrhea and bloody stool scores, but did not reduce body weight. Histological analysis revealed that in both the TNBS and DSS models, colon inflammation was much more severe in the saline-treated group than in the AM-treated group. These findings indicate that the anti-inflammatory properties of AM make it an effective therapeutic agent for the treatment of IBD in rats.

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Gastroprotective effect of adrenomedullin administered subcutaneously in the rat

Cited by 26 publications

References 22 publications

Brain neuropeptides in gastric mucosal protection

Brain neuropeptides in gastric mucosal protection

Adrenomedullin regulates intestinal physiology and pathophysiology

Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease

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