Gastroprotective Effect of Anisomeles indica on Aspirin-Induced Gastric Ulcer in Mice

Abstract

Gastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the Helicobacter pylori infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, adverse effects have emerged following long-term treatment. Natural medicines are used as alternative therapeutic agents in the treatment of gastric ulcers, with few side effects. Despite various reports on the anti-H. pylori and anti-gastric cancer activities of Anisomeles indica, its gastroprotective effect on ulcers remains undetermined. This study investigated the protective effect of A. indica on aspirin-induced gastric ulcers in murine models. Our results show that three fractions of ethanol-extracted A. indica inhibited aspirin-induced gastric injury. Among these, A. indica Fraction 1 was observed to enrich ovatodiolide, which effectively diminished gastric acidity and alleviated aspirin-induced inflammation in the stomach. Our results provide evidence that A. indica could be developed as an effective therapeutic agent for gastroprotective purposes.

Evaluation of Gastroprotective Activity of the Methanolic Extract of Justicia pectoralis Jacq. (Acanthaceae)

“…Although current therapy is effective in the treatment of peptic ulcers, it is notable that the disease still has a high prevalence and continues to be a health problem worldwide. In this way, it becomes necessary to investigate natural medicinal plants and their derivatives as alternatives for therapy and the minimization of side effects [2,27].…”

Management of NSAID-Induced Penetrating Gastric Ulcer Complicated by Hemorrhagic Cholecystitis: The Role of Percutaneous Transhepatic Biliary Drainage

“…The patient's presentation with epigastric pain, nausea, and vomiting following high NSAID intake was suspicious of NSAID-induced gastrointestinal damage [ 14 ]. NSAIDs are known to compromise the gastric mucosal barrier, increasing the risk of ulcers [ 15 ].…”

The Gastroprotective Effects of Anisomeles indica against Ethanol-Induced Gastric Ulcer through the Induction of IκB-α and the Inhibition of NF-κB Expression

“…The whole A. indica plant was obtained from the contractual farms of SYI Biotechnology (Taichung, Taiwan). A. indica extract was prepared as previously described [15] with minor modifications. The formulation of A. indica HP813 powder included soluble fiber from corn, xylo-oligosaccharides, and A. indica extract powder.…”

“…Anisomeles indica (L.) Kuntze, a plant of the genus Anisomeles in the family Lamiaceae [11,12], is a traditional herbal medicine commonly used in Taiwan. The results of recent studies have revealed that A. indica extracts have pharmacological activities, including anti-inflammatory activities, tumor cell growth inhibition, treatment of gastrointestinal and liver diseases, treatment of inflammatory skin diseases, and anti-H. pylori activities [13][14][15]. Previous studies have isolated some chemical constituents from A. indica, including apigenin, ovatodiolide, β-sitosterol, and acteoside [16,17].…”